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p-tert-Butyltoluene
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 98–51–1
NIOSH REL: 10 ppm (60 mg/m3) TWA, 20 ppm (120 mg/m3) STEL
Current OSHA PEL: 10 ppm (60 mg/m3) TWA
1989 OSHA PEL: 10 ppm (60 mg/m3) TWA, 20 ppm (120 mg/m3) STEL
1993-1994 ACGIH TLV: 1 ppm (6.1 mg/m3) TWA
Description of Substance: Colorless liquid with a distinct aromatic odor, somewhat like gasoline.
LEL: . . Unknown
Original (SCP) IDLH: 1,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the female rat 1-hour LC50 of 934 ppm reported by Hine et al. [1954].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
|---|---|---|---|---|---|---|
| RatRat
Rat Rat Mouse |
Hine et al. 1954Hine et al. 1954
Hine et al. 1954 Hine et al. 1954 Hine et al. 1954 |
934734
248 165 248 |
———-
—– —– —– |
1 hr2 hr
4 hr 8 hr 4 hr |
1,168 ppm (1.25)1,174 ppm (1.6)
496 ppm (2.0) 413 ppm (2.5) 496 ppm (2.0) |
117 ppm117 ppm
50 ppm 41 ppm 50 ppm |
Other animal data: RD50 (mouse), 360 ppm [Nielsen and Alarie 1982].
Human data: Giddiness and altered respiration have been reported in volunteers exposed to 160 ppm for 15 minutes [Hine et al. 1954].
| Revised IDLH: 100 ppmBasis for revised IDLH: The revised IDLH for p-tert-butyltoluene is 100 ppm based on acute inhalation toxicity data in humans [Hine et al. 1954]. |
REFERENCES:
1. Hine CH, Ungar H, Anderson HH, Kodama JK, Critchlow JK, Jacobsen NW [1954]. Toxicological studies on p-tertiary-butyltoluene. AMA Arch Ind Hyg Occup Med 9:227-244.
2. Nielsen GD, Alarie Y [1982]. Sensory irritation, pulmonary irritation, and respiratory stimulation by airborne benzene and alkylbenzenes: prediction of safe industrial exposure levels and correlation of their thermodynamic properties. Toxicol Appl Pharmacol 65:459-477.