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1-Chloro-1-nitropropane
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 600–25–9
NIOSH REL: 2 ppm (10 mg/m3) TWA
Current OSHA PEL: 20 ppm (100 mg/m3) TWA
1989 OSHA PEL: 2 ppm (10 mg/m3) TWA
1993-1994 ACGIH TLV: 2 ppm (10 mg/m3) TWA
Description of Substance: Colorless liquid with an unpleasant odor.
LEL: . . Unknown
Original (SCP) IDLH: 2,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement in Patty [1963] that 1 of 2 guinea pigs died following a 1-hour exposure to 2,178 ppm; no rabbits died from this exposure, and no rabbits or guinea pigs died from a 1-hour exposure to 1,069 ppm [Machle et al. 1945].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| G. pigRabbit
Rabbit G. pig Mouse |
Machle et al. 1945Machle et al. 1945
Machle et al. 1945 Machle et al. 1945 Neklesova and Kudrina 1969 |
2,178—–
LC100: 2,574 —– 12,840 |
—–389
—– 3,502 —– |
1 hr6 hr
6 hr 2 hr 3 hr |
2,723 ppm (1.25)895 ppm (2.3)
5,920 ppm (2.3) 5,603 ppm (1.6) 23,112 ppm (1.8) |
272 ppm90 ppm
592 ppm 560 ppm 2,311 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RabbitRat
Mouse |
Machle et al. 1945Marhold 1986
Neklesova and Kudrina 1969 |
oraloral
oral |
———-
510 |
5050
—– |
68 ppm68 ppm
695 ppm |
6.8 ppm6.8 ppm
70 ppm |
Human data None relevant for use in determining the revised IDLH.
| Revised IDLH: 100 ppmBasis for revised IDLH: The revised IDLH for 1-chloro-1-nitropropane is 100 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945]. |
REFERENCES:
1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.
2. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 596 (in Czechoslovakian).
3. Neklesova ID, Kudrina MA [1969]. Comparative toxicological characteristics of certain chloronitroparaffins. Gig Sanit 34(10-12):429-432 (translated).
4. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2082.