HIV Funding and Budget

This section provides information on current CDC HIV prevention funding opportunities and grants, as well as information about CDC’s HIV budget. Please visit these pages frequently to find updated information on HIV prevention funding opportunities from CDC.

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Funding Opportunities Open to Applicants

Applying for Secure Deduplication Tool for HIV Surveillance CDC-RFA-PS-24-0121
The purpose of this NOFO is to support a more efficient method for HIV surveillance jurisdictions to identify potential interstate duplicates. The recipient will develop and provide a secure, encrypted, ongoing secure data-sharing tool capable of identifying potential duplicates across jurisdictions.
Notice of Funding Opportunity PS24-0020: Capacity Building Assistance (CBA) for HIV Prevention Programs to End the HIV Epidemic in the United States
This Notice of Funding Opportunity (NOFO) supports the network of funded providers under this NOFO, established and referenced as the CBA Provider Network (CPN), to implement the six inter-related program components.
Notice of Funding Opportunity PS-24-0047: High-Impact HIV Prevention and Surveillance Programs for Health Departments
This Notice of Funding Opportunity (NOFO) allows for flexibility while ensuring that funding resources are reaching the geographic areas with the highest HIV burden and greatest need. The NOFO priorities are to increase knowledge of HIV status, reduce HIV transmission, prevent new HIV infections, improve linkage to care and viral suppression and maintain elimination of perinatal transmission. The integration of core prevention, surveillance, and Ending the HIV Epidemic (EHE) funding resources allows each jurisdiction to align resources to better match the geographic burden of HIV infections within their jurisdictions and maximize the impact of federal HIV prevention funding.
Notice of Funding Opportunity PS-24-039: Improving the Quality of Life of People with HIV Aged 50 Years and Older in the United States
This Notice of Funding Opportunity (NOFO) is to support investigator-driven research to explore and identify factors related to quality of life (QOL) for persons with HIV aged 50 years and older (PWH50+). QOL has been recognized as an important aspect of health for people with HIV. Applicants are expected to conceive, design, develop, direct, and conduct formative qualitative and mixed method research to explore factors that impact QOL for PWH50+, translate findings into strategies to improve QOL for PWH50+, assess strategies for acceptability with PWH50+ and/or their HIV service providers, and disseminate findings to organizations and partners serving PWH50+. Findings from this NOFO are expected to contribute towards improving QOL for people with HIV and are aligned with the HIV National Strategic Plan (2022-2025) and the goals of the national Ending the HIV Epidemic in the U.S. (EHE) initiative, “Treat” Pillar.
Notice of Funding Opportunity PS-24-042: A Bridge to Adherence: Long-Acting Antiretroviral Therapy for People with HIV Released from Prison
The purpose of this NOFO is to support research on long-acting injectable (LAI) antiretroviral therapy (ART) by implementing and evaluating LAI-ART use among people soon to be released from prisons to the community and the effects of such use on the achievement and maintenance of HIV care continuum metrics. Recipients of this NOFO will conduct qualitative and quantitative research resulting in data describing real-world LAI-ART use in an era of multiple HIV treatment modalities.
Notice of Funding Opportunity Announcement PS24-063: Minority HIV Research Initiative (MARI): Epidemiologic, Behavioral, and Implementation Science Research in Racial/Ethnic Minority Communities Disproportionately Affected by HIV and Build Research Capacity Among Historically Underrepresented Researchers
The purpose of this Notice of Funding Opportunity (NOFO) is to support promising epidemiologic, behavioral, and implementation science research addressing the drivers of health inequities in racial and ethnic minority communities disproportionately affected by HIV while strengthening the capacity for conducting such research among underrepresented investigators working in these communities. The NOFO supports CDC’s goals to promote health and reduce disease and disability by funding research that has the potential to result in high public health impact.
Notice of Funding Opportunity Announcement PS24-0026:Implementation of Community Health Worker-Mediated Services for Re-Engagement to Care and Outreach for Persons with HIV in Rural Communities (REACH: Rural Re-Engagement and Care using CHWs for Persons with HIV)
This NOFO will fund recipients to work with HIV care providers to develop a CHW-mediated approach to re-engagement to care and outreach services for PWH in rural communities. CHWs will provide services that may include, but are not limited to, ART delivery, sample collection for standard HIV laboratory testing, transfer of self-collected specimens, transportation services, arranging and scheduling telehealth visits with the HIV medical providers and with other providers (mental health, primary care) and offering evidence-based medication adherence support.
Notice of Funding Opportunity PS23-001: Increasing PrEP Use Among Black Cisgender Women in the United States (HerPrEP)
The purpose of this NOFO is to support an implementation research study to evaluate strategies to increase HIV pre-exposure prophylaxis (PrEP) use among Black/African American (Black) cisgender women in the United States. The recipient should implement and evaluate strategies in healthcare clinics to increase PrEP provision by healthcare providers and PrEP use by Black cisgender women.
Notice of Funding Opportunity PS-23-006: Identifying and Addressing Historical and Structural Drivers of Medical Mistrust among Hispanic/Latino Gay, Bisexual and Other Men Who Have Sex with Men (HLMSM) for HIV Prevention.
This new funding opportunity announcement is an opportunity to (1) identify drivers of medical mistrust (MM) in Hispanic/Latino (H/L) populations in the United States with special attention to gay, bisexual and other men who have sex with men (HLMSM), and (2) address this social determinant of health by implementing and evaluating multilevel interventions in selected sites. Describing trauma from diverse H/L descent will lead to culturally centered and trustworthy multilevel interventions that will in turn decrease health disparities.
Notice of Funding Opportunity PS-23-005: Expanding Rapid Initiation of Antiretroviral Therapy in Non-traditional Settings: Emergency Department
The purpose of this NOFO is to support research to investigate how to deploy and optimize rapid ART delivery in emergency departments that are currently routinely screening for HIV infection. Emergency departments offer a unique opportunity to immediately engage with newly diagnosed patients to initiate ART and provide linkage to an HIV provider in the community. This research may help determine whether HIV testing and rapid ART in EDs can improve engagement, linkage and retention in care, and viral suppression among newly diagnosed people with HIV (PWH), as well as those previously diagnosed with HIV but who are not engaged in care.
Notice of Funding Opportunity PS-23-004: Long-Acting Injectables for the Treatment of HIV in Non-Clinic Community-Based Settings
The purpose of this NOFO is to support research on long-acting injectable (LAI) antiretroviral therapy (ART) by implementing LAI-ART administration in non-clinic settings. Utilizing an innovative strategy of LAI-ART administration in non-clinic-based settings to decentralize the delivery of LAI-ART for HIV treatment will expand treatment opportunities. Recipients of this NOFO will conduct qualitative and quantitative research resulting in data describing real-world LAI-ART use in an era of multiple HIV treatment modalities.
Notice of Funding Opportunity PS23-003: Exploring Preferences for Long-Acting Antiretroviral Therapies (LA-ART) in a Community-Based Sample of Priority Populations Living with HIV Who are Disproportionately Affected
This Notice of Funding Opportunity will support qualitative research to inform strategies to strengthen uptake and adherence to ART and reduce existing disparities in HIV viral suppression among cis-gender Black women with HIV (CgBWH).
Notice of Funding Opportunity PS23-002: Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)
This Notice of Funding Opportunity will support research on evidence of effectiveness of TeleART and supplemental strategies to support ART adherence and retention in care for people with HIV (PWH). Recipients of this NOFO will implement a hybrid effectiveness-implementation research study to (1) evaluate the effectiveness of an enhanced telehealth program for maintenance of HIV medication adherence among clinically stable people with HIV (PWH); (2) identify potential implementation facilitators and challenges by evaluating the delivery of these strategies; and (3) evaluate the cost and cost-effectiveness of providing telehealth to patients on ART as well as evaluate program enhancements that include, but may not be limited to, biospecimen sample self-collection and the use of specialized staff such as community health workers and patient navigators.
Notice of Funding Opportunity PS22-2211: Enhanced Surveillance of Persons with Early and Late HIV Diagnosis
This NOFO is a re-announcement of PS22-2202. The purpose of this NOFO is to improve understanding of barriers and gaps in HIV prevention services that may lead to continued HIV transmission or delayed diagnosis of HIV. This NOFO will support enhanced surveillance of people diagnosed with HIV during the earliest and latest stages of infection (i.e., stages 0 and 3, respectively) to understand recent experiences with HIV prevention and testing services, as well as the system- and individual-level barriers that led to these failures in early diagnosis and prevention. Recipients of this NOFO will identify, locate, and recruit all persons diagnosed in the past year with stage 0 or stage 3 infection in their jurisdiction for participation in behavioral interviews conducted by a CDC contractor.
Notice of Funding Opportunity PS22-2210: Mass Mailing of HIV Self-Tests to Persons Disproportionately Affected by HIV in the U.S.
The purpose of this NOFO is optimize the recipient’s existing web-based ordering portal and distribution program to distribute at least 875,000 HIVSTs to U.S. populations disproportionately affected by HIV. The NOFO will primarily maximize distribution of HIV self-tests to gay, bisexual and other men who have sex with men, transgender women, and Black cis-gender women via digital and traditional marketing strategies from CDC’s Let’s Stop HIV Together campaigns, predominately in EHE jurisdictions. The use of the program’s HIV self-tests and referrals to prevention services, including pre-exposure prophylaxis and antiretroviral treatment will increase awareness of HIV infection, prevent new HIV infections, and improve overall health and well-being of program participants.
Notice of Funding Opportunity Announcement PS22-2209: Transgender Status-Neutral Community-to-Clinic Models to End the HIV Epidemic (TRANSCEND)
This NOFO will fund organizations to work in TG clinics and partner with TG CBOs to develop community-to-clinic models for integrated status-neutral HIV prevention and care services, gender-affirming services including hormone therapy, and primary health care. Navigation will also be used to link TG persons to services as needed for mental health and substance use disorder and other essential support services. These models will increase use of HIV prevention and treatment by TG persons to decrease HIV transmission and improve overall health and wellbeing.
Notice of Funding Opportunity PS22-2202: Enhanced Surveillance of Persons with Early and Late HIV Diagnosis
The purpose of this NOFO is to improve understanding of barriers and gaps in HIV prevention services that may lead to continued HIV transmission or delayed diagnosis of HIV. This NOFO will support enhanced surveillance of people diagnosed with HIV during the earliest and latest stages of infection (i.e., stages 0 and 3, respectively) to understand recent experiences with HIV prevention and testing services, as well as the system- and individual-level barriers that led to these failures in early diagnosis and prevention. Recipients of this NOFO will identify, locate, and recruit all persons diagnosed in the past year with stage 0 or stage 3 infection in their jurisdiction for participation in behavioral interviews conducted by a CDC contractor.
Notice of Funding Opportunity PS22-2203: Comprehensive High-Impact HIV Prevention Programs for Young Men of Color Who have Sex with Men and Young Transgender Persons of Color
The purpose of this NOFO is to implement comprehensive high-impact HIV prevention programs to address health disparities among YMSM of color, YTG persons of color, and their partners with the goal of reducing HIV transmission and HIV-associated morbidity and mortality. This NOFO aligns with the goals of the HIV National Strategic Plan, 2021-2025 (HIV Plan) and supports the goals of reducing all new HIV infections by 75% by 2025 and 90% by 2030, which complements the Ending the HIV Epidemic in the United States (EHE) initiative. This program also supports the HIV Plan’s health equity goals of addressing social determinants of health and syndemics affecting HIV-related outcomes.
PS22-2201: National HIV Behavioral Surveillance (NHBS)
CDC has published the Notice of Funding Opportunity PS22-2201, National HIV Behavioral Surveillance (NHBS). The purpose of NHBS is to support ongoing national bio-behavioral surveillance to monitor HIV-related behaviors, detect changes over time in HIV risk behaviors among populations overburdened by HIV infections, and to inform and evaluate HIV prevention activities. This NOFO also aims to fill gaps in knowledge regarding HIV prevention priorities among populations in geographic areas where current data are limited.
PS21-2104: Partnering and Communicating Together (PACT)
CDC announces the availability of fiscal year 2021 funds for a Notice of Funding Opportunity (NOFO) to support CDC human immunodeficiency virus (HIV) prevention efforts as part of the Administration’s Ending the HIV Epidemic in the U.S. initiative.
PS21-2102: Comprehensive High-Impact HIV Prevention Programs for Community Based Organizations
The NOFO focuses on addressing the national HIV epidemic by reducing new infections, increasing access to care, and promoting health equity in accordance with the Ending the HIV Epidemic in the U.S. initiative and CDC’s High-Impact HIV Prevention approach. This will be achieved by enhancing Community-Based Organizations’ capacity to increase HIV testing and referrals to Partner Services, link persons with HIV to HIV medical care and ART, provide and/or refer to prevention and essential support services, including Syringe Services Programs (SSPs), for persons with HIV and persons at risk for acquiring HIV, and increase program monitoring and accountability.
PS20-2010: Integrated HIV Programs for Health Departments to Support Ending the HIV Epidemic in the United States
This Notice of Funding Opportunity (NOFO) supports the development and implementation of programs tailored to ending the HIV epidemic in America. Recent scientific advances in HIV prevention and treatment have made ending the HIV epidemic in America a realistic possibility. The purpose of this NOFO is to implement comprehensive HIV programs, that complement programs, such as the Ryan White program and other HHS programs, designed to support ending the HIV epidemic in America by leveraging powerful data, tools and resources to reduce new HIV infections by 75% in 5 years.
PS19-1906: Strategic Partnerships and Planning to Support Ending the HIV Epidemic in the United States
(Close date 07/12/2019 ) (Estimated award date: 09/30/2019) (Project Period: September 30, 2019 – September 29, 2024)
The purpose of this notice of funding opportunity is to support strategic partnerships, communication, peer-to-peer technical assistance (TA), and jurisdictional planning efforts to address emerging needs of targeted jurisdictions through CDC-funded state and local health departments and their ability to the end the HIV epidemic in the U.S.
PS19-1904: Capacity Building Assistance (CBA) for High Impact HIV Prevention Program Integration
(Close date 11/12/2018) (Estimated award date: 4/1/2019) (Project Period: April 1, 2019 – March 31, 2024) (replaced PS14-1403)
The purpose of this notice of funding opportunity is to support a CBA Provider Network (CPN) to implement the following four program components: 1) national training; 2) regional technical assistance; 3) continuous quality improvement and sustainability for community-based organizations; and 4) marketing and administrative support for the CPN.

Ongoing Funding Opportunities

PS18-1802: Integrated HIV Surveillance and Prevention Programs for Health Departments
(Close date 9/13/2017) (Estimated award date: 1/1/2018) (Project Period: January 1, 2018–December 31, 2022) (replaces PS12-1201)
The purpose of this funding opportunity announcement is to implement a comprehensive HIV surveillance and prevention program to prevent new HIV infections and achieve viral suppression among persons living with HIV.
PS17-1704: Comprehensive High-Impact HIV Prevention Projects for Young Men of Color Who Have Sex with Men and Young Transgender Persons of Color (Close date 09/14/2016) (Project period: April 1, 2017–March 31, 2018) (replaced PS11-1113)
This funding stream is offered to CBOs to develop and implement High-Impact HIV Prevention Programs in for: Young Men of Color Who Have Sex with Men (YMSM of color) and Young Transgender Persons of Color (YTG of color) and their partners regardless of age, gender, and race/ethnicity.
PS16-160102CONT16: National HIV Behavioral Surveillance (NHBS) (Close date 08/1/2016)
This award is a continuation of funds only for grantees previously awarded under CDC-RFA-PS16-1601: National HIV Behavioral Surveillance (NHBS).
PS15-151002CONT16: Training and Technical Assistance for Health Department Demonstration Projects for Comprehensive Prevention, Care, Behavioral Health, and Social Services for Men Who Have Sex with Men of Color At Risk for and Living with HIV Infection aka TA 2 THRIVE (Targeted Highly Effective Interventions to Reverse the HIV Epidemic). (3 years) This is a continuation of funds intended only for grantees previously awarded under PS15-1510.
PS15-150902CONT16: Health Department Demonstration Projects for Comprehensive Prevention, Care, Behavioral Health, and Social Services for Men Who Have Sex with Men (MSM) of Color at Risk for and Living with HIV Infection (3 years) This award is a continuation of funds intended only for grantees previously awarded under CDC-RFA-PS 15-1509.
PS15-1506: Health Department Demonstration Projects to Reduce HIV Infections and Improve Engagement in HIV Medical Care among Men Who Have Sex with Men (MSM) and Transgender Persons (3 years) The purpose of this FOA is to support up to 24 state and local health departments in the United States to implement PrEP (Category 1) and Data to Care (Category 2) demonstration projects prioritizing populations of MSM and transgender persons at high risk for HIV infection, particularly persons of color.
PS15-1505: Enhancing HIV Prevention Communication and Mobilization Efforts Through Strategic Partnership (5 years)
PS15-150202CONT17: Comprehensive High-Impact HIV Prevention Projects for Community-Based Organizations (5 years)
This award is a continuation of funds intended only for grantees previously awarded under CDC-RFA-PS 15-1502.
PS14-1409: Assisting Directly Funded AIDS Directors in Urban Jurisdictions and Other HIV Prevention Partners in Meeting the Changes in the Public Healthcare Systems and HIV Prevention Landscape (5 years)
PS14-140503CONT16: Technical Assistance to Support AIDS Directors and HIV Prevention Program Managers in the 50 States, District of Columbia, the Commonwealth of Puerto Rico, the US Virgin Islands, and the Pacific Islands
PS14-1403: Capacity Building Assistance for High-Impact HIV Prevention (5 years—through 3/31/2019)
PS13-130205CONT17: National HIV Surveillance System (NHSS) (Close date 08/15/2016) (5 years)
This funding stream is a five-year funding opportunity for health departments in states and territories to collect and report HIV case surveillance data to the National HIV Surveillance System (NHSS).

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