An official website of the United States government
Preventing New HIV Infections
The listed guidelines and related implementation resources provide guidance about prevention strategies and services that can prevent or diagnose new HIV infections and link individuals at risk to relevant prevention, medical and social services.
Guidelines
| Current Guidelines | Some sections may be out-of-date. | Out of date/Superseded |
|---|---|---|
 |
 |
 |
Pre-Exposure Prophylaxis (PrEP)
| Title and Description | Publication Year | Status |
|---|---|---|
| Preexposure Prophylaxis for the Prevention of HIV Infection in the United States (2021 Update) – Clinical Practice Guideline [PDF – 2 MB] This updates the review of scientific evidence on the safety and efficacy of antiretroviral HIV preexposure prophylaxis (PrEP). The update includes guidance for recommended initial and follow-up STD screening, revised HIV testing strategies, and recommended primary care practices for patients being prescribed oral or injectable PrEP. |
2021 | |
| Preexposure Prophylaxis for the Prevention of HIV Infection in the United States (2021 Update) – Clinical Providers Supplement [PDF – 764 KB] This update provides revised checklists, patient information sheets, and billing codes for both oral and injectable PrEP and includes guidance for counseling patients about adherent PrEP use. |
2021 | |
Non-Occupational Post-Exposure Prophylaxis
| Title and Description | Publication Year | Status |
|---|---|---|
| Guidance for Non-HIV-Specialized Providers Caring for Persons with HIV Who Have been Displaced by Disasters (such as a Hurricane) Provides guidance to health care providers attending to the medical needs of adults and children with HIV who have been displaced from disaster areas and who have not yet secured HIV care in the areas where they have relocated. |
2018 | |
| Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV—United States, 2016 Updates and expands the 2005 U.S. Department of Health and Human Services recommendations for clinical care providers regarding nonoccupational postexposure prophylaxis (nPEP) for exposure to human immunodeficiency virus (HIV) outside the health care setting for persons in the United States. The update includes pediatric dosing information. |
2016 | |
| Recommendations for Postexposure Interventions to Prevent Infection with Hepatitis B Virus, Hepatitis C Virus, or Human Immunodeficiency Virus, and Tetanus in Persons Wounded During Bombings and Other Mass–Casualty Events—United States Outlines and adapts existing general recommendations on the use of immunization and postexposure prophylaxis for tetanus and for occupational and nonoccupational exposures to bloodborne pathogens to the specific situation of a mass-casualty event. Note: Information about the use of PEP with HIV has been updated in newer guidelines |
2008 | |
Occupational Post-Exposure Prophylaxis
| Title and Description | Publication Year | Status |
|---|---|---|
| Updated (2013) U.S. Public Health Service Guidelines for the Management of Occupational Exposures to Human Immunodeficiency Virus and Recommendations for Postexposure Prophylaxis (oPEP) Updates U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and/or other body fluids that might contain HIV. Although the principles of exposure management remain unchanged, recommended HIV postexposure prophylaxis (PEP) regimens and the duration of HIV follow-up testing for exposed personnel have been updated. |
2018 | |
Prevention with Partners of Persons with HIV
| Title and Description | Publication Year | Status |
|---|---|---|
| Recommendations for Partner Services Programs for HIV Infection, Syphilis, Gonorrhea, and Chlamydial Infection This report provides updated, integrated recommendations for services provided to partners of persons with human immunodeficiency virus (HIV) infection and three other sexually transmitted diseases (STDs) (i.e., syphilis, gonorrhea, and chlamydial infection.) Note: Some recommendations and supporting evidence have been updated in the Recommendations for HIV Prevention with Adults and Adolescents with HIV. Implementation Resources: |
2008 | |
Screening for STDS
| Title and Description | Publication Year | Status |
|---|---|---|
| HIV Infection: Detection, Counseling, and Referral Provides updated recommendations for the screening and treatment of persons who have or are at risk for sexually transmitted diseases (STDs) including HIV |
Contraceptive Use
| Title and Description | Publication Year | Status |
|---|---|---|
| The United States Medical Eligibility Criteria for Contraceptive Use, 2016 (US MEC) The information in this report updates the 2010 U.S. MEC (CDC. U.S. Medical Eligibility Criteria for Contraceptive Use, 2010. MMWR 2010:59 [No. RR-4]) and includes recommendations for using specific contraceptive methods by women and men who have certain characteristics or medical conditions. Notable updates include the addition of recommendations for women with sexually transmitted diseases, human immunodeficiency virus, or who are using antiretroviral therapy. |
2016 | |
Other
| Title and Description | Publication Year | Status |
|---|---|---|
| Recommendations to Improve Preconception Health and Health Care—United States: a Report Of The CDC/ATSDR Preconception Care Work Group and the Select Panel on Preconception Care Provides recommendations to improve both preconception health and care. The goal of these recommendations is to improve the health of women and couples, before conception of a first or subsequent pregnancy. Note: Some of the recommendations have been updated/adapted in the Recommendations for HIV Prevention with Adults and Adolescents with HIV. |
2006 | |
Implementation Guidance
| Title and Description | Publication
Year |
Status |
|---|---|---|
| Quick Guide: Recommendations For Partner Services Programs For HIV Infection, Syphilis, Gonorrhea, And Chlamydial Infection Intended to serve as a quick reference resource and as such, lists only the recommendations and data security guidelines included in the MMWR
Note: Some of the recommendations on partner services have been updated in the Recommendations for HIV Prevention with Adults and Adolescents with HIV |
2010 | |
| Partner Services Evaluation Field Guide (PSEFG)Provides organizations, specifically health department personnel at the state and local levels, with step-by-step instructions to assist in the development and implementation of monitoring and evaluation activities for partner services programs. | 2010 | |