Background
Researchers, cancer registry staff, and others use U.S. Cancer Statistics data to advance scientific knowledge and reduce cancer. Stat Bites, data briefs, and a selection of peer-reviewed journal articles that use U.S. Cancer Statistics data are highlighted below.
Stat Bites
218,893 new lung cancers were reported in the U.S. in 2022.
147,931 new colorectal cancers were reported in the U.S. in 2022.
255,395 new prostate cancers were reported in the U.S. in 2022.
279,731 new breast cancers were reported in females in the U.S. in 2022.
Data briefs
36.7 million new cancer cases were reported in U.S. Cancer Statistics from 2003 to 2022.
This report examines breast, prostate, lung, and colorectal cancer rates by county-level urbanicity.
About 49,900 HPV-associated cancers occurred in the United States each year from 2018 to 2022.
In 2022, 255,395 new prostate cancers were reported in the U.S. Most were found at the local stage.
More lung cancers are being found at an early stage when they are more treatable.
Mesothelioma is a cancer that forms in the tissue that lines many internal organs.
Breast cancer rates have been increasing slowly among women younger than 45.
Selected journal articles
2026
- Ayoub NL, Francoeur AA, Chang J, et al. Population-level trends in lifestyle factors and early-onset breast, colorectal, and uterine cancers. Cancers (Basel). 2026;18(1):167.
- Gopalani SV, Qin J, Wu M, Senkomago V. Declines in cervical cancer incidence among young women in the United States. J Natl Cancer Inst. 2026;118(5):941–946.
- Henley SJ, Adam EE, Kava CM, Wu M. Temporal trends in lung cancer cases diagnosed at early stage. JAMA Oncol. 2026:e261199.
- Johnson C, Liao CI, Jiang RL, et al. The impact of climate vulnerability on cancer incidence among U.S. women. Cureus. 2026;18(1):e102478.
- Kava CM, Dai S, Siegel DA, et al. Differences in lung cancer survival by demographic characteristics and social determinants of health, United States, 2010–2020. Public Health Rep. 2026:333549251410521.
- Patel C, Abboud Y, Karkra R, et al. Trends in early-onset colorectal adenocarcinoma and neuroendocrine tumors across racial and ethnic groups. J Clin Med. 2026;15(4):1316.
- Santiago-Rodríguez EJ, White JS, Bailey ZD, Allen IE, Hiatt RA, Shariff-Marco S. Residential segregation and late-stage colorectal cancer in the United States: a population-based study of 1.2 million adults. Am J Epidemiol. 2026;195(4):1163–1174.
- Shiels MS, Haque AT, Jones RR, et al. Trends in childhood and adolescent cancer incidence rates in the United States between 2001 and 2022. Cancer Discov. 2026;16(4):686–696.
- Vasireddy A, Abboud Y, Iyer PG, Gaddam S, Kamboj AK. Stable trends in incidence of young-onset esophageal adenocarcinoma: a 20-year analysis from the United States Cancer Statistics database. Clin Gastroenterol Hepatol. 2026;24(5):1458–1460.e3.
2025
- Agarwal R, King JB, Gopalani SV, Senkomago V. Cervical cancer incidence and trends among women aged 15–29 years by county-level economic status and rurality—United States, 2007–2020. Cancer Epidemiol. 2025;94:102730.
- Burus T, Patel MI, Christian WJ, Huang B, Lang Kuhs KA. Sex-based differences in histologic lung cancer incidence trends in the United States, 2005–2019. Int J Cancer. 2025;156(9):1716–1725.
- Espinoza AF, Onwuka E, Siegel DA, Dai S, Vasudevan SA, Scheurer ME, Lupo PJ. Incidence and survival of children and adolescents with Wilms tumor, United States, 2001–2020. Cancer Med. 2025;14(3):e70598.
- Francoeur AA, Liao CI, Johnson CR, et al. Trends in the incidence and mutational landscape of advanced uterine cancer. Int J Gynecol Cancer. 2025;35(1):100013.
- Kava CM, Siegel DA, Qin J, Sabatino SA, Wison R, Wu M. Patterns and differences in lung cancer treatment—United States, 2015–2020. Chest. 2025;167(4):1218–1231.
- Selvaraj RC, Cioffi G, Waite KA, Jackson SS, Barnholtz-Sloan JS. A pan-cancer analysis of age and sex differences in cancer incidence and survival in the United States, 2001–2020. Cancers (Basel). 2025;17(3):378.
- Semprini JT, Pabón-Rodríguez FM, Santiago-Rodríguez EJ, Almodóvar-Rivera IA. Quantifying the burden of cancer in Puerto Rico's oldest residents. Cancer Epidemiol. 2025;97:102838.
- Sherman RL, Firth AU, Henley SJ, et al. Annual Report to the Nation on the Status of Cancer, featuring state-level statistics after the onset of the COVID-19 pandemic. Cancer. 2025;131(9):e35833.
- Siegel DA, Kava CM, Spector LG, et al. Pediatric and young adult cancer incidence in the United States during the COVID-19 pandemic. Pediatr Blood Cancer. 2025;72(11):e31976.
- Suárez-Ramos T, Verganza S, Pagán-Santana Y, et al. Evaluating the impact of hurricanes and the COVID-19 pandemic on colorectal cancer incidence in Puerto Rico: An interrupted time-series analysis. Cancer. 202;131(8):e35793.
- Tsegaye AT, Shing JZ, Vo JB, Kreimer AR, Shiels MS. Racial and ethnic differences in HPV-related cancer incidence in the United States, 2001–2020. J Natl Cancer Inst. 2025:djaf107.
2024
- Arnett A, Siegel DA, Dai S, et al. Incidence and survival of pediatric and adult hepatocellular carcinoma, United States, 2001–2020. Cancer Epidemiol. 2024;92:102610.
- Bryant-Genevier J, Kava CM, Melkonian SC, Siegel DA. State and regional trends in incidence and early detection of lung cancer among US adults, 2010–2020. Prev Chronic Dis. 2024;21:E55.
- Campbell K, Siegel DA, Umaretiya PJ, et al. A comprehensive analysis of neuroblastoma incidence, survival, and racial and ethnic disparities from 2001 to 2019. Pediatr Blood Cancer. 2024;71(1):e30732.
- Gopalani SV, Senkomago V, Rim SH, Saraiya M. Human papillomavirus-associated anal squamous cell carcinoma: sociodemographic, geographic, and county-level economic trends in incidence rates—United States, 2001–2019. J Natl Cancer Inst. 2024;116(2):275–282.
- Negoita S, Chen HS, Sanchez PV, et al. Annual Report to the Nation on the Status of Cancer, part 2: early assessment of the COVID-19 pandemic's impact on cancer diagnosis. Cancer. 2024;130(1):117–127.
2023
- Ellington TD, Werner AK, Henley SJ, Paddock LE, Agovino PK. Feasibility of visualizing cancer incidence data at sub-county level: findings from 21 National Program of Cancer Registries. Spat Spatiotemporal Epidemiol. 2023;45:100564.
- Holman DM, King JB, White A, Singh SD, Lichtenfeld JL. Acral lentiginous melanoma incidence by sex, race, ethnicity, and stage in the United States, 2010–2019. Prev Med. 2023:175:107692.
- Siegel DA, King JB, Lupo PJ, et al. Counts, incidence rates, and trends of pediatric cancer in the United States, 2003–2019. J Natl Cancer Inst. 2023;115(11):1337–1354.
2022
- Chang SH, Patel N, Du M, Liang PS. Trends in early-onset vs. late-onset colorectal cancer incidence by race/ethnicity in the United States Cancer Statistics database. Clin Gastroenterol Hepatol. 2022;20(6):e1365–e1377.
- Cho MY, Siegel DA, Demb J, Richardson LC, Gupta S. Increasing colorectal cancer incidence before and after age 50: implications for screening initiation and promotion of "on-time" screening. Dig Dis Sci. 2022;67(8):4086–4091.
- Cronin KA, Scott S, Firth AU, et al. Annual Report to the Nation on the Status of Cancer, part 1: national cancer statistics. Cancer. 2022;128(24):4251–4284.
- Ellington TD, Miller JW, Henley SJ, Wilson RJ, Wu, M, Richardson LC. Trends in breast cancer incidence, by race, ethnicity, and age among women aged ≥ 20 years—United States, 1999–2018. MMWR Morb Mortal Wkly Rep. 2022;71(2):43.
- Liao CI, Francoeur AA, Kapp DS, Caesar MAP, Huh WK, Chan JK. Trends in human papillomavirus–associated cancers, demographic characteristics, and vaccinations in the US, 2001–2017. JAMA Netw Open. 2022;5(3):e222530.
- Melkonian SC, Jim MA, Pete D, et al. Cancer disparities among non-Hispanic urban American Indian and Alaska Native populations in the United States, 1999–2017. Cancer. 2022;128(8):1626–1636.
- Minihan AK, Patel AV, Flanders WD, Goding Sauer A, Jemal A, Islami F. Proportion of cancer cases attributable to physical inactivity by US state, 2013–2016. Med Sci Sports Exerc. 2022;54(3):417–423.
- Raza SA, da Costa WL, Thrift AP. Increasing incidence of gallbladder cancer among non-Hispanic Blacks in the United States: a birth cohort phenomenon. Cancer Epidemiol Biomarkers Prev. 2022;31(7):1410–1417.
- Shah RR, Millien VO, da Costa WL, Oluyomi AO, Gould Suarez M, Thrift AP. Trends in the incidence of early-onset colorectal cancer in all 50 United States from 2001 through 2017. Cancer. 2022;128(2):299–310.