U.S. Case Data: Monkeypox

Data reported to CDC as of December 2, 2025

What to know

U.S. monkeypox case trends data will be updated the first week of every month. The majority of U.S. monkeypox cases are clade II and continue to be in people who are not vaccinated or who have only received one dose of JYNNEOS. Two doses of JYNNEOS are recommended to provide maximum protection.

Trends of monkeypox cases reported to CDC by date*^

*Date is defined as the earliest date available regarding the case (i.e., date of illness onset, diagnosis date, positive laboratory test report date, or date reported to CDC).

Case counts include those who tested positive for either monkeypox virus or orthopoxvirus as described in the case definition.

^ Includes all monkeypox cases (clade I and clade II) reported to CDC

The 7-day moving average (denoted by the orange line) calculates the average number of cases per day in the previous 7 days.