Vital Signs: Deaths Among Persons with Diagnosed HIV Infection, United States, 2010–2018

Weekly / November 20, 2020 / 69(46);1717–1724

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Karin A. Bosh, PhD1; Anna Satcher Johnson, MPH1; Angela L. Hernandez, MD1; Joseph Prejean, PhD1; Jocelyn Taylor, MPH1; Rachel Wingard, MA1; Linda A. Valleroy, PhD1; H. Irene Hall, PhD1 (View author affiliations)

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Summary

What is already known about this topic?

HIV remains among the 10 leading causes of death among certain populations, although deaths attributable to HIV infection are preventable.

What is added by this report?

Deaths among persons with diagnosed HIV (PWDH) decreased, primarily because of decreases in HIV-related deaths. The age-adjusted rate per 1,000 PWDH of HIV-related deaths decreased 48% and non–HIV-related deaths decreased 9% during 2010–2017. Differences in HIV-related deaths persist for certain populations.

What are the implications for public health practice?

Continued efforts in diagnosing HIV early, promptly initiating treatment, and maintaining access to high-quality care and treatment are necessary for continuing progress in reducing deaths and eliminating differences across populations.

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Abstract

Background. Life expectancy for persons with human immunodeficiency virus (HIV) infection who receive recommended treatment can approach that of the general population, yet HIV remains among the 10 leading causes of death among certain populations. Using surveillance data, CDC assessed progress toward reducing deaths among persons with diagnosed HIV (PWDH).

Methods. CDC analyzed National HIV Surveillance System data for persons aged ≥13 years to determine age-adjusted death rates per 1,000 PWDH during 2010–2018. Using the International Classification of Diseases, Tenth Revision, deaths with a nonmissing underlying cause were classified as HIV-related or non–HIV-related. Temporal changes in total deaths during 2010−2018 and deaths by cause during 2010–2017 (2018 excluded because of delays in reporting), by demographic characteristics, transmission category, and U.S. Census region of residence at time of death were calculated.

Results. During 2010–2018, rates of death decreased by 36.6% overall (from 19.4 to 12.3 per 1,000 PWDH). During 2010–2017, HIV-related death rates decreased 48.4% (from 9.1 to 4.7), whereas non–HIV-related death rates decreased 8.6% (from 9.3 to 8.5). Rates of HIV-related deaths during 2017 were highest by race/ethnicity among persons of multiple races (7.0) and Black/African American persons (5.6), followed by White persons (3.9) and Hispanic/Latino persons (3.9). The HIV-related death rate was highest in the South (6.0) and lowest in the Northeast (3.2).

Conclusion. Early diagnosis, prompt treatment, and maintaining access to high-quality care and treatment have been successful in reducing HIV-related deaths and remain necessary for continuing reductions in HIV-related deaths.

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Introduction

Persons with human immunodeficiency virus (HIV) infection require lifelong treatment to reduce HIV-related morbidity and mortality; advances in HIV treatment have resulted in a life expectancy that approaches that of the general population (1,2). Deaths attributable to HIV infection are preventable, yet during 2017, HIV was still among the 10 leading causes of death among certain population groups (3).

The National HIV Surveillance System (NHSS) is the primary source of population-based information about HIV in the United States (4). A previous analysis demonstrated that, during 1990–2011, deaths among persons with stage 3 HIV infection (acquired immunodeficiency syndrome [AIDS]) decreased, with larger decreases in HIV-attributable deaths (−89%) than in non–HIV-attributable deaths (−57%) (5). On the basis of increasing evidence of the benefits of antiretroviral therapy both for persons with HIV and for preventing secondary transmission, treatment guidelines were updated in 2012 to recommend antiretroviral therapy for all persons with HIV (6). A national target for reducing the death rate among persons with diagnosed HIV (PWDH) by ≥33% during 2010–2020 was established to encourage progress toward improving health outcomes among PWDH (7). Using NHSS data, CDC assessed such progress, with an emphasis on HIV-related deaths, at the national and state levels.

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Methods

CDC analyzed NHSS data reported through December 2019 regarding deaths during 2010–2018 among persons aged ≥13 years with diagnosed HIV infection. Using the International Classification of Diseases, Tenth Revision (ICD-10) codes associated with the underlying cause, deaths were classified as HIV-related or non–HIV-related.* Annual deaths (2010–2018) and deaths by cause (2010–2017 because of delays in reporting) were assessed by demographic characteristics, transmission category, and U.S. region of residence at time of death. National-level results include persons with a residence at time of death in the 50 states or the District of Columbia; jurisdiction-level results also include persons with a residence at time of death in Puerto Rico.

Age-adjusted rates per 1,000 PWDH were calculated using the U.S. 2000 standard population. For HIV-related deaths, CDC calculated an absolute and a relative disparity measure for race/ethnicity and assessed change from 2010 to 2017.†,§ For all measures, only stable rates (calculated on the basis of ≥12 deaths) and rates by cause of death for groups among whom ≥85% of deaths had a known cause (i.e., complete cause of death reporting) were assessed for temporal changes and for differences among groups.

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Results

During 2010–2018, the number of deaths among PWDH decreased by 7.5%, from 16,742 during 2010 to 15,483 during 2018; the rate of death decreased by 36.6% overall (Figure 1). The rate of HIV-related deaths decreased 48.4% from 9.1 per 1,000 PWDH during 2010 to 4.7 per 1,000 PWDH during 2017, whereas the rate of non–HIV-related deaths decreased 8.6% from 9.3 in 2010 to 8.5 in 2017 (Figure 1). The rate of HIV-related deaths during 2010–2017 decreased in all regions and for all gender, age, race/ethnicity, and transmission category groups. (Supplementary Table 1, https://stacks.cdc.gov/view/cdc/96933). The absolute rate difference disparity measure for HIV-related deaths between Hispanic/Latino persons and White persons decreased to zero (3.9 per 1,000 PWDH in both populations) in 2017. During 2010–2017, the absolute rate difference disparity measure between Black/African American (Black) persons and White persons decreased by 66.0%, and between persons of multiple races and White persons decreased 36.7%. The relative rate ratio disparity measure between Black persons and White persons decreased 23.2%, between Hispanic/Latino persons and White persons decreased 17.7%, but between persons of multiple races and White persons increased 2.3%.

Rates of HIV-related deaths during 2017 were higher among females (5.4 per 1,000 PWDH) than males (4.5) and transgender females (females assigned male sex at birth) (4.3), and highest among persons of multiple races (7.0) and Black persons (5.6), followed by White persons (3.9) and Hispanic/Latino persons (3.9) (Table 1). The rates of HIV-related deaths increased with age, from 1.6 among PWDH aged 13–24 years to 8.4 among persons aged ≥55 years. However, the proportion of deaths that were HIV-related decreased with increasing age from 48.6% among PWDH aged 13–24 years with a known cause of death to 30.0% among PWDH aged ≥55 years with a known cause of death because the rate of non–HIV-related death increased with age more than the rate of HIV-related death. Among males, the rate of HIV-related death was lower among those whose infection was attributed to male-to-male sexual contact (3.9) than among those whose infection was attributed to other transmission categories; among females, the rate was lower among those with infection attributed to heterosexual contact (4.6) than among those in other transmission categories. The rate of HIV-related deaths was highest in the South (6.0) and lowest in the Northeast (3.2).

In all areas with complete cause-of-death reporting and with stable rates, HIV-related deaths were lower during 2017 than in 2010 (Supplementary Table 2, https://stacks.cdc.gov/view/cdc/96934). Rates of HIV-related deaths during 2017 varied by jurisdiction; rates were highest in Mississippi (10.3 per 1,000 PWDH), Puerto Rico (9.2), and South Carolina (8.0), and lowest in New York (3.0), Massachusetts (3.1) and Delaware (3.2) (Figure 2). During 2017, rates of HIV-related deaths by race/ethnicity varied by jurisdiction (Table 2) (Supplementary Table 3, https://stacks.cdc.gov/view/cdc/96934). Rates of HIV-related death were highest among White persons in South Carolina (10.1), Oklahoma (7.5), and Arkansas (6.5); highest among Black persons in Mississippi (11.5), Louisiana (8.8), South Carolina (8.2), and Nevada (8.2); and highest among Hispanic/Latino persons in Puerto Rico (9.2), Texas (6.5), and Arizona (6.2).

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Discussion

By 2018, the rate of death among PWDH in the United States had decreased by 36.6% from what it was in 2010, surpassing the 2020 national target of ≥33% (7). This decrease, which was primarily attributable to reductions in HIV-related deaths, likely reflects the increase during 2010–2018 in the proportion of persons who knew their serostatus from 82.2% to 86.2% and the implementation of updated treatment guidelines resulting in increased viral suppression among PWDH from 46.0% to 64.7% (6,8). Absolute and relative differences in HIV-related deaths among Black persons and Hispanic/Latino persons, compared with those among White persons, also decreased during 2010–2017. This reduction likely reflects a greater relative improvement during 2012–2017 in the time from diagnosis to viral suppression among Black persons, compared with White persons (9), and reduced disparities during 2010–2016 in viral suppression among Black persons and Hispanic/Latino persons, compared with White persons (10). These findings highlight how successes in identifying HIV infections, initiating treatment, and achieving viral suppression among PWDH improve health outcomes.

Despite success in reducing rates of HIV-related deaths among PWDH, differences still exist by gender, race/ethnicity, age, transmission category, and region. Variation in timely diagnosis and treatment initiation, along with ongoing treatment, likely contributes to differences in HIV-related deaths. During 2015, delays in HIV diagnosis were longer among non-White racial/ethnic groups and males with HIV infection attributed to heterosexual contact (11). Timely initiation of treatment, as measured by the proportion of persons with suppressed viral loads ≤6 months after diagnosis, and receipt of ongoing, recommended treatment, as measured by the proportion of PWDH with a suppressed viral load, varied during 2017 by gender, age, race/ethnicity, transmission category, and region (8,12); populations with higher rates of HIV-related deaths were less likely to have evidence of timely initiation of treatment and ongoing treatment as demonstrated through lower proportions of viral suppression in the population.

Prevalence of HIV infection and the number of HIV-related deaths were greatest by race/ethnicity among Black persons and by U.S. region in the South (4). Rates of HIV-related deaths were also high among these two populations. Higher levels of poverty, unemployment, and persons uninsured, challenges associated with accessing care, and HIV-related stigma likely affect timely diagnosis and access to treatment and contribute to higher rates of HIV-related deaths (13,14). Expanded efforts to address these and other structural barriers are critical to improving health outcomes, including reducing differences in HIV-related death rates, especially among Black persons and persons in the South.

Although rates of HIV-related deaths were lower among younger PWDH, the proportion of HIV-related deaths among younger PWDH (ages 13–44 years) was higher than that among older PWDH; this is concerning because HIV-related deaths are preventable. Higher proportions of undiagnosed HIV infections and lower levels of viral suppression are more common among younger persons (8,15). Additional efforts are needed to ensure younger persons are aware of their infection and able to access and adhere to recommended, ongoing HIV treatment to improve health outcomes.

CDC supports numerous activities for identifying HIV infections: initiating treatment as quickly as possible and ensuring ongoing treatment; addressing social barriers to HIV prevention and treatment efforts; and expanding opportunities for persons to test for HIV infection and receive the results on their own (i.e., self-testing), which allows persons who might not otherwise take a test to learn their HIV status (16). CDC’s Integrated HIV Surveillance and Prevention Programs for Health Departments, initiated in 2018, includes critical activities to enable state and local health departments to improve identification of HIV infections and increase viral suppression among PWDH (17). CDC’s national campaign, Let’s Stop HIV Together, supports efforts to end HIV stigma and promote HIV testing, prevention, and treatment (18). Ending the HIV Epidemic: A Plan for America is an initiative for reducing HIV infections in the United States by ≥90% by 2030; it focuses on strategies regarding diagnosis, treatment, prevention, and response to HIV infection in communities most affected by HIV (19). In addition to decreasing the risk for ongoing HIV transmission, prompt diagnosis and improving timely and continuing access to HIV treatment should also improve health outcomes for PWDH and prevent HIV-related deaths.

The findings in this report are subject to at least two limitations. First, cause-of-death information on death certificates is typically completed by funeral directors, attending physicians, medical examiners, or coroners (3). HIV-related deaths might be underreported because of lack of knowledge about the correct documentation needed or reluctance to include HIV on the death certificate because of possible stigma (5). An assessment of Florida’s HIV surveillance data for 2000–2011 indicated that HIV-related deaths were underestimated in the surveillance system by approximately 9% (20). Second, the proportion of deaths with a known cause was <100%. Overall, the proportion of deaths with a known cause was high for the United States (94.6% in 2010 and 96.7% in 2017); however, the proportion of deaths with a known cause was lower for certain demographic groups (e.g., Asian persons) and for certain jurisdictions (e.g., Hawaii during 2017).

Deaths among persons with HIV have decreased, and by 2018 had surpassed the 2020 national target, primarily because of a reduction in HIV-related deaths. Deaths caused by HIV infection have likely decreased because of improvements in diagnosing infections and in treatment and medical care. However, differences in HIV-related death rates still exist for multiple populations. Diagnosing HIV infection early, treating it promptly, and maintaining access to high-quality care and treatment over a lifetime can improve life expectancy and reduce differences in rates of deaths across all populations.

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Acknowledgment

Xueyuan (Bill) Dong, ICF Corporation, Atlanta, Georgia.

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Corresponding author: Karin A. Bosh, hxx8@cdc.gov, 404-639-3615.

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1Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

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All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

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* HIV-related: deaths with an ICD-10 code of B20–B24, 098.7, or R75 for the underlying cause; non–HIV-related: all other deaths with a nonmissing ICD-10 code for the underlying cause.

† Absolute rate difference disparity measure: Difference between age-adjusted rate per 1,000 PWDH among selected race/ethnicity and White persons (population with lowest rate during 2010 among those with rates where ≥85% of deaths had a known cause). Change in the absolute rate difference disparity measure during 2010–2017 was calculated as ([absolute disparity measure in 2017 – absolute disparity measure in 2010]/absolute disparity measure in 2010) x 100.

§ Relative rate ratio disparity measure: Ratio of age-adjusted rates per 1,000 PWDH for selected race/ethnicity, compared with White persons (population with lowest rate during 2010 among those with rates where ≥85% of deaths had a known cause). Change in the relative rate ratio disparity measure during 2010–2017 was calculated as ([relative disparity measure in 2017 – relative disparity measure in 2010]/relative disparity measure in 2010) x 100.

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References

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Return to your place in the textFIGURE 1. Age-adjusted rates* of total deaths,† human immunodeficiency virus (HIV)–related deaths,§ and non–HIV-related deaths among persons aged ≥13 years with diagnosed HIV infection — United States, 2010–2018
The figure is a line chart showing the age-adjusted rates of total deaths, human immunodeficiency virus (HIV)–related deaths, and non–HIV-related deaths among persons aged ≥13 years with diagnosed HIV infection, in the United States, during 2010–2018.

* Rates per 1,000 persons with diagnosed HIV infection. Rates age-adjusted using the U.S. 2000 standard population.

† Deaths among persons with diagnosed HIV infection regardless of cause of death (n = 16,742 in 2010; n = 15,483 in 2018).

§ HIV-related deaths include deaths with an underlying cause with an International Classification of Diseases, Tenth Revision code of B20-B24, O98.7, or R75. Non–HIV-related deaths include all other deaths with a known underlying cause.

Deaths by cause available through 2017 because of reporting delays.

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TABLE 1. Total deaths, human immunodeficiency virus (HIV)–related deaths, and non–HIV-related deaths among persons aged ≥13 years with diagnosed HIV infection, by selected characteristics — United States, 2017Return to your place in the text
Characteristic Total HIV-related* Non–HIV-related*
No. Age-adjusted rate per 1,000 PWDH† No. % of deaths related to HIV % of deaths with known cause related to HIV Age-adjusted rate per 1,000 PWDH† No. Age-adjusted rate per 1,000 PWDH†
Gender
Male 12,256 13.5 4,033 32.9 34.1 4.5 7,779 8.5
Female 3,994 14.1 1,466 36.7 37.7 5.4 2,425 8.3
Transgender male-to-female§ 103 14.8 33 32.0 32.4 4.3 69 10.2
Transgender female-to-male§ 4 18.0 2 50.0 50.0 10.7 2 7.3
Additional gender identity 1 13.8 0 0 0 0 1 13.8
Age at death, yrs
13–24 151 3.5 70 46.4 48.6 1.6 74 1.7
25–34 1,048 6.5 492 46.9 48.8 3.0 516 3.2
35–44 1,838 9.4 826 44.9 46.4 4.2 954 4.9
45–54 4,470 14.4 1,584 35.4 36.6 5.1 2,740 8.9
≥55 8,851 28.9 2,562 28.9 30.0 8.4 5,992 19.5
Race/Ethnicity
American Indian/Alaska Native 44 13.5 8 18.2 21.1 3.3 30 8.3
Asian** 88 6.3 27 30.7 39.1 1.5 42 3.1
Black/African American 7,197 15.1 2,620 36.4 37.3 5.6 4,412 9.2
Hispanic/Latino†† 2,694 11.1 955 35.4 37.2 3.9 1,609 6.6
Native Hawaiian/Other Pacific Islander** 9 15.0 0 0 0 0 2 2.5
White 5,255 13.3 1,546 29.4 30.5 3.9 3,520 8.9
Multiple races 1,069 19.5 378 35.4 36.5 7.0 659 12.0
Transmission category§§
Male adult or adolescent¶¶
Male-to-male sexual contact 7,010 11.4 2,408 34.4 35.6 3.9 4,351 7.1
Injection drug use 2,168 22.7 590 27.2 28.1 6.2 1,506 15.8
Male-to-male sexual contact and injection drug use 1,373 19.1 444 32.4 33.3 6.1 889 12.6
Heterosexual contact*** 1,705 16.1 579 34.0 35.6 5.8 1,046 9.5
Other††† 104 19.0 44 42.4 43.4 6.6 57 11.9
Subtotal 12,360 13.5 4,066 32.9 34.1 4.5 7,849 8.5
Female adult or adolescent¶¶
Injection drug use 1,373 21.6 454 33.0 33.7 7.7 893 13.1
Heterosexual contact*** 2,553 12.0 974 38.2 39.3 4.6 1,506 7.1
Other††† 72 16.2 40 56.2 59.6 7.0 27 8.9
Subtotal 3,998 14.1 1,468 36.7 37.7 5.4 2,427 8.3
U.S. Census region of residence at time of death
Midwest 1,901 14.1 602 31.7 32.3 4.4 1,263 9.4
Northeast 3,689 12.0 941 25.5 26.8 3.2 2,576 8.2
South 8,040 15.5 3,092 38.5 39.1 6.0 4,822 9.2
West 2,728 11.4 899 33.0 35.8 3.9 1,615 6.6
Total 16,358 13.6 5,534 33.8 35.0 4.7 10,276 8.5

Abbreviation: PWDH = persons with diagnosed HIV infection.
* HIV-related deaths include deaths with an underlying cause with an International Classification of Diseases, Tenth Revision code of B20–B24, O98.7, or R75. Non–HIV-related deaths include all other deaths with a known underlying cause. Deaths with an unknown underlying cause are excluded.
† PWDH includes persons living with HIV infection at the end of the calendar year plus the number of diagnoses of HIV infection during the current calendar year. Rates age-adjusted using the U.S. 2000 standard population. Rates presented by age at time of death are not age-adjusted. Rates and percentage change calculated on the basis of <12 deaths are considered unstable and should be interpreted with caution.
§ “Transgender male-to-female” includes persons who were assigned “male” sex at birth but have ever identified as “female.” “Transgender female-to-male” includes persons who were assigned “female” sex at birth but have ever identified as “male.”
Additional gender identity examples include “bigender,” “gender queer,” and “two-spirit.”
** Data by cause of death should be interpreted with caution because <85% of reported deaths were reported with a known underlying cause of death.
†† Hispanic/Latino persons can be of any race.
§§ Data have been statistically adjusted to account for missing transmission category; therefore, values might not sum to column subtotals and total.
¶¶ Data presented are based on sex at birth and include transgender persons.
*** Heterosexual contact with a person known to have, or to be at high risk for, HIV infection.
††† Includes hemophilia, blood transfusion, perinatal, and risk factor not reported or not identified.

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Return to your place in the textFIGURE 2. Age-adjusted rates* of human immunodeficiency virus (HIV)–related deaths among persons aged ≥13 years with diagnosed HIV infection, by area of residence at time of death — United States and Puerto Rico, 2017
The figure is a map showing the age-adjusted rate of human immunodeficiency virus (HIV)–related deaths among persons aged ≥13 years with diagnosed HIV infection, by area of residence at time of death, in the United States and Puerto Rico, during 2017.

Abbreviations: DC = District of Columbia; PR = Puerto Rico.

* Rates per 1,000 persons with diagnosed HIV infection. Rates age-adjusted using the U.S. 2000 standard population. HIV-related deaths include deaths with an underlying cause with an International Classification of Diseases, Tenth Revision, code of B20 –B24, 098.7, or R75. Other U.S. dependent areas are excluded because they do not report underlying cause of death information. Jurisdictions with striped shading are those with <85% of deaths in 2017 with a known underlying cause of death. Rates from Alaska, Idaho, Maine, Montana, Nebraska, New Hampshire, New Mexico, North Dakota, Rhode Island, Utah, Vermont, and West Virginia are calculated based on <12 deaths and should be interpreted with caution.

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TABLE 2. Total deaths and human immunodeficiency virus (HIV)–related deaths among persons aged ≥13 years with diagnosed HIV infection, by area of residence at time of death, and selected race/ethnicity categories — United States and Puerto Rico,* 2017Return to your place in the text
Area of residence All races/ethnicities Black/African American Hispanic/Latino White
Total Total HIV-related† Total HIV-related† Total HIV-related†
No. Age-adjusted rate per 1,000 PWDH§ % of deaths with a known cause No. Age-adjusted rate per 1,000 PWDH§ No. Age-adjusted rate per 1,000 PWDH§ No. Age-adjusted rate per 1,000 PWDH§ No. Age-adjusted rate per 1,000 PWDH§ No. Age-adjusted rate per 1,000 PWDH§ No. Age-adjusted rate per 1,000 PWDH§
Alabama 257 17.8 98.4 150 17.5 60 6.5 5 11.4 2 5.2 83 19.5 29 6.1
Alaska 7 8.5 100.0 0 0 0 0 1 11.8 0 0 5 14.0 1 1.6
Arizona 247 13.5 99.6 29 14.9 10 6.1 56 12.3 26 6.2 145 14.7 48 4.6
Arkansas 107 17.0 99.1 33 12.3 16 6.2 6 15.7 3 7.9 61 19.2 21 6.5
California 1,717 11.0 89.7 327 12.1 118 4.4 509 10.2 195 3.9 724 10.4 193 2.8
Colorado 132 8.4 100.0 13 5.9 6 2.8 33 12.2 12 4.9 77 7.2 33 3.1
Connecticut 198 15.0 99.5 72 14.7 18 4.9 57 12.6 15 3.7 64 18.8 16 4.0
Delaware 67 13.8 100.0 50 18.0 13 4.6 4 13.6 1 3.8 11 6.5 1 0.5
District of Columbia 237 13.4 97.0 202 16.2 59 5.3 3 3.5 1 1.2 14 4.6 2 0.6
Florida 2,122 15.6 98.4 1,049 17.5 424 7.2 329 11.0 124 4.1 683 16.2 199 4.7
Georgia 823 14.5 97.7 559 15.3 244 6.5 43 12.5 18 4.2 158 12.0 38 2.9
Hawaii 37 15.2 35.1 1 5.6 0 0 1 3.3 1 3.3 12 7.0 2 0.8
Idaho 20 13.6 100.0 0 0 0 0 1 2.6 1 2.6 17 16.4 6 5.8
Illinois 498 12.8 99.2 289 16.6 76 4.4 48 7.3 14 1.8 124 11.2 30 2.1
Indiana 212 17.1 97.2 66 15.7 20 5.4 10 10.6 6 6.4 126 20.3 44 5.6
Iowa 44 13.1 100.0 11 16.9 6 9.7 3 7.0 1 2.3 26 11.3 10 4.4
Kansas 47 14.4 97.9 11 16.0 7 11.1 6 10.8 2 2.1 29 14.1 12 5.1
Kentucky 138 16.4 97.8 44 17.0 17 6.3 5 6.4 3 3.9 82 16.8 24 4.8
Louisiana 411 18.5 98.8 276 19.0 125 8.8 7 5.8 1 0.7 115 19.8 34 6.3
Maine 35 15.6 100.0 1 2.5 0 0 2 12.0 1 4.9 31 19.0 7 5.9
Maryland 597 14.7 98.3 412 14.0 132 4.4 26 9.5 9 3.0 84 18.9 19 3.8
Massachusetts 307 11.6 96.1 64 8.3 14 2.6 90 13.1 27 4.2 144 13.7 33 2.8
Michigan 273 15.6 99.3 160 17.2 49 5.1 13 14.9 4 3.2 88 12.5 27 3.8
Minnesota 91 9.3 98.9 27 8.3 15 4.0 6 6.9 3 2.1 52 10.2 19 4.2
Mississippi 220 21.2 98.6 158 22.1 85 11.5 9 36.7 6 21.3 44 19.3 12 5.5
Missouri 213 14.5 97.2 97 16.7 38 6.5 10 13.1 6 7.8 95 13.6 30 3.9
Montana 15 20.9 100.0 0 0 0 0 4 93.8 2 34.1 8 11.4 1 1.6
Nebraska 33 14.3 93.9 11 20.2 4 5.7 2 6.9 1 5.4 20 14.9 4 2.5
Nevada 174 16.1 97.7 50 20.5 19 8.2 23 9.6 9 3.4 90 15.9 26 4.6
New Hampshire 21 13.7 95.2 0 0 0 0 3 15.5 0 0 18 17.2 6 6.0
New Jersey 646 13.8 98.6 324 15.1 105 5.2 141 12.1 43 3.9 118 11.9 25 3.0
New Mexico 61 13.1 98.4 2 8.4 0 0 24 11.2 4 2.0 25 12.4 3 1.4
New York 1,787 10.7 98.3 661 10.7 164 3.0 635 11.0 170 3.0 247 7.2 59 1.9
North Carolina 547 15.1 98.9 338 15.3 137 6.1 19 7.9 8 3.5 152 15.1 48 4.6
North Dakota 3 8.9 100.0 0 0 0 0 1 131.2 1 131.2 2 8.7 1 4.4
Ohio 377 15.5 97.9 152 15.2 53 5.5 21 10.7 7 3.7 176 16.7 50 4.2
Oklahoma 109 16.8 95.4 22 13.5 11 7.1 6 8.9 1 1.0 65 20.3 22 7.5
Oregon 115 12.4 100.0 5 9.6 1 1.9 9 7.9 6 5.3 96 13.4 36 5.1
Pennsylvania 650 14.5 81.8 301 14.4 55 2.5 105 14.7 21 3.0 202 14.4 34 2.4
Puerto Rico 401 19.1 99.0 0 0 0 0 400 19.1 181 9.2 1 21.9 0 0
Rhode Island 33 9.6 97.0 7 8.6 3 3.5 6 8.6 2 3.2 17 9.5 4 2.2
South Carolina 337 17.2 97.9 236 17.7 110 8.2 5 6.4 2 2.3 83 19.3 34 10.1
South Dakota 9 12.4 33.3 2 9.1 1 3.9 0 0 0 0 4 10.0 0 0
Tennessee 332 18.2 99.4 189 19.9 81 7.7 6 9.2 2 3.2 128 17.3 48 5.8
Texas 1,413 15.1 98.9 557 17.3 245 7.4 359 12.8 182 6.5 409 14.6 157 5.8
Utah 22 8.4 95.5 1 4.2 1 4.2 3 9.8 0 0 16 7.0 8 3.4
Vermont 12 11.4 100.0 0 0 0 0 1 7.5 0 0 10 12.2 3 3.2
Virginia 292 10.5 98.3 180 11.8 60 4.1 9 3.3 6 2.1 79 9.0 27 3.2
Washington 175 10.4 97.1 24 10.8 9 4.2 19 9.3 6 2.8 112 10.8 35 3.8
West Virginia 31 13.8 100.0 4 7.5 1 2.1 1 11.9 0 0 24 15.8 6 4.6
Wisconsin 101 12.7 100.0 30 11.7 8 3.3 9 9.0 0 0 57 13.8 18 4.2
Wyoming 6 27.2 66.7 0 0 0 0 0 0 0 0 3 9.5 1 3.5

Abbreviation: PWDH = persons with diagnosed HIV infection.
* Other U.S. dependent areas are excluded because they do not report underlying cause of death information.
† HIV-related deaths include deaths with an underlying cause with an International Classification of Diseases, Tenth Revision code of B20–B24, O98.7, or R75. Non–HIV-related deaths include all other deaths with a known underlying cause. Deaths with an unknown underlying cause are excluded.
§ PWDH includes persons living with HIV infection at the end of the calendar year plus the number of diagnoses of HIV infection during the current calendar year. Rates age-adjusted using the U.S. 2000 standard population. Rates calculated based on consideration that analyses of data with <12 deaths are considered unstable and should be interpreted with caution.
Proportion of deaths with a known underlying cause of death is <85%.

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Suggested citation for this article: Bosh KA, Johnson AS, Hernandez AL, et al. Vital Signs: Deaths Among Persons with Diagnosed HIV Infection, United States, 2010–2018. MMWR Morb Mortal Wkly Rep 2020;69:1717–1724. DOI: http://dx.doi.org/10.15585/mmwr.mm6946a1.

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