Vaccine Schedule & Dosing

Key points

  • The Dengvaxia dengue vaccine requires three doses for full protection.
  • The vaccine doses are given 6 months apart.
  • Dengvaxia is administered subcutaneously.
A line of vials containing clear liquid on a blue background.

Details

Preparation
  • Requires mixing of diluent and lyophilized vaccine antigen in single use vials
Dosage
  • 0.5 mL per dose
Route
  • Subcutaneous injection
Schedule
  • Three-dose series, given 6 months apart

Co-administration

Trials have evaluated co-administration of Dengvaxia with other vaccines, including yellow fever, diphtheria, tetanus, acellular pertussis (DTaP), inactivated polio, Haemophilus influenzae types b and a, and measles, mumps, and rubella (MMR). No safety issues have been reported.

Vaccine providers should follow best practice guidance from the Advisory Committee on Immunization Practices, which states that injectable, live-attenuated vaccines not administered simultaneously should be separated by at least 4 weeks.

Vaccine Administration After Dengue Virus Infection

Children and adolescents with dengue should wait at least 6 months after the date the dengue infection is confirmed to begin the vaccine series.

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Content Source:
National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)