Viral Hepatitis Surveillance Report 2018 – Appendix

APPENDIX

Number of reported acute viral hepatitis cases and estimated infections with 95% bootstrap confidence intervals — United States, 2011–2018

 

Year Hepatitis A
Reported
Hepatitis A
Estimated*
(95% bootstrap
confidence interval)
Hepatitis B
Reported
Hepatitis B
Estimated*
(95% bootstrap
confidence interval)
Hepatitis C
Reported
Hepatitis C
Estimated*
(95% bootstrap
confidence interval)
Appendix table
2011 1,398 2,800
(2,000–3,100)
2,903 18,900
(10,700–46,200)
1,232 17,100
(13,600–58,400)
2012 1,562 3,100
(2,200–3,400)
2,895 18,800
(10,700–46,000)
1,778 24,700
(19,600–84,300)
2013 1,781 3,500
(2,500–3,900)
3,050 19,800
(11,300–48,500)
2,138 29,700
(23,500–101,400)
2014 1,239 2,500
(1,700–2,800)
2,791 18,100
(10,300–44,400)
2,194 30,500
(24,200–104,200)
2015 1,390 2,800
(1,900–3,100)
3,370 21,900
(12,500–53,600)
2,436 33,900
(26,800–115,500)
2016 2,007 4,000
(2,800–4,400)
3,218 20,900
(11,900–51,200)
2,967 41,200
(32,600–140,600)
2017 3,366 6,700
(4,700–7,400)
3,409 22,200
(12,600–54,200)
3,216 44,700
(35,400–152,400)
2018 12,474 24,900
(17,500–27,400)
3,322 21,600
(12,300–52,800)
3,621 50,300
(39,800–171,600)

Source: CDC, National Notifiable Diseases Surveillance System.

* To account for under-estimation, a probabilistic model to estimate the true incidence (symptomatic and asymptomatic cases) of acute hepatitis A, B, and C from reported (symptomatic) cases has been published previously(7). The model includes the probabilities of symptoms, referral to care and treatment, and rates of reporting to local and state health departments. The published multipliers have since been corrected by CDC to indicate that each reported case of hepatitis A represents 2.0 estimated infections (95% bootstrap confidence interval [CI]: 1.4-2.2), each reported case of acute hepatitis B represents 6.5 estimated infections (95% CI: 3.7-15.9), and each reported case of hepatitis C represents 13.9 estimated infections (95% CI: 11.0-47.4).