About
This table describes the number of cases of tuberculosis disease by initial drug regimen in the United States from 1993 to 2024.
Key Highlights
- In 2024, 95% of persons with TB disease were initially started on a CDC recommended regimen or another multi-drug regimen that contained at least four drugs.
- The percentage of persons with TB disease that were initially started on a newer 4-month regimen that includes isoniazid, rifapentine, moxifloxacin, and pyrazinamide (HPMZ) increased from 2023 to 2024.
Data Table
Tuberculosis Cases and Percentages by Initial Drug Regimen: United States, 1993–2024
| Year | Total cases1 | HRZE2 | HPMZ3 | Multi (4+) drug regimen4 | Less than 4 drug regimen5 | ||||
|---|---|---|---|---|---|---|---|---|---|
| No. | (%) | No. | (%) | No. | (%) | No. | (%) | ||
| 2024 | 10,037 | 8,841 | (88.1) | 57 | (0.6) | 660 | (6.6) | 479 | (4.8) |
| 2023 | 9,349 | 8,045 | (86.1) | 29 | (0.3) | 806 | (8.6) | 469 | (5.0) |
| 2022 | 8,060 | 6,996 | (86.8) | 18 | (0.2) | 593 | (7.4) | 453 | (5.6) |
| 2021 | 7,592 | 6,570 | (86.5) | 1 | (0.0) | 562 | (7.4) | 459 | (6.0) |
| 2020 | 6,947 | 6,006 | (86.5) | -- | -- | 542 | (7.8) | 399 | (5.7) |
| 2019 | 8,660 | 7,428 | (85.8) | -- | -- | 759 | (8.8) | 473 | (5.5) |
| 2018 | 8,786 | 7,535 | (85.8) | -- | -- | 785 | (8.9) | 466 | (5.3) |
| 2017 | 8,887 | 7,653 | (86.1) | -- | -- | 723 | (8.1) | 511 | (5.7) |
| 2016 | 9,018 | 7,894 | (87.5) | -- | -- | 688 | (7.6) | 436 | (4.8) |
| 2015 | 9,315 | 8,142 | (87.4) | -- | -- | 670 | (7.2) | 503 | (5.4) |
| 2014 | 9,178 | 8,027 | (87.5) | -- | -- | 646 | (7.0) | 505 | (5.5) |
| 2013 | 9,313 | 8,057 | (86.5) | -- | -- | 707 | (7.6) | 549 | (5.9) |
| 2012 | 9,704 | 8,488 | (87.5) | -- | -- | 676 | (7.0) | 540 | (5.6) |
| 2011 | 10,237 | 8,945 | (87.4) | -- | -- | 606 | (5.9) | 686 | (6.7) |
| 2010 | 10,879 | 9,396 | (86.4) | -- | -- | 674 | (6.2) | 809 | (7.4) |
| 2009 | 11,241 | 9,704 | (86.3) | -- | -- | 653 | (5.8) | 884 | (7.9) |
| 2008 | 12,627 | 10,853 | (86.0) | -- | -- | 740 | (5.9) | 1,034 | (8.2) |
| 2007 | 12,974 | 11,087 | (85.5) | -- | -- | 633 | (4.9) | 1,254 | (9.7) |
| 2006 | 13,402 | 11,375 | (84.9) | -- | -- | 668 | (5.0) | 1,359 | (10.1) |
| 2005 | 13,753 | 11,714 | (85.2) | -- | -- | 485 | (3.5) | 1,554 | (11.3) |
| 2004 | 14,189 | 11,875 | (83.7) | -- | -- | 512 | (3.6) | 1,802 | (12.7) |
| 2003 | 14,474 | 11,949 | (82.6) | -- | -- | 506 | (3.5) | 2,019 | (13.9) |
| 2002 | 14,689 | 11,984 | (81.6) | -- | -- | 443 | (3.0) | 2,262 | (15.4) |
| 2001 | 15,530 | 12,558 | (80.9) | -- | -- | 446 | (2.9) | 2,526 | (16.3) |
| 2000 | 15,868 | 12,631 | (79.6) | -- | -- | 495 | (3.1) | 2,742 | (17.3) |
| 1999 | 16,940 | 13,227 | (78.1) | -- | -- | 583 | (3.4) | 3,130 | (18.5) |
| 1998 | 17,724 | 13,309 | (75.1) | -- | -- | 616 | (3.5) | 3,799 | (21.4) |
| 1997 | 19,061 | 13,768 | (72.2) | -- | -- | 772 | (4.1) | 4,521 | (23.7) |
| 1996 | 20,424 | 13,760 | (67.4) | -- | -- | 884 | (4.3) | 5,780 | (28.3) |
| 1995 | 21,849 | 13,706 | (62.7) | -- | -- | 1,055 | (4.8) | 7,088 | (32.4) |
| 1994 | 23,196 | 12,930 | (55.7) | -- | -- | 1,281 | (5.5) | 8,985 | (38.7) |
| 1993 | 23,961 | 9,667 | (40.3) | -- | -- | 1,180 | (4.9) | 13,114 | (54.7) |
1Persons alive at diagnosis with initial drug regimen information.
2H, isoniazid; R, rifampin; Z, pyrazinamide; E, ethambutol.
3Four-month regimen with H, isoniazid; P, rifapentine; M, moxifloxacin; and Z, pyrazinamide.
4A drug regimen with at least four drugs, other than HRZE and HPMZ.
5Includes some recommended multi-drug regimens for drug-resistant TB as well as persons who were not prescribed any drugs.
Notes
Data for all years are updated through July 10, 2025.
Double dashes (--) indicate that data are not available.