At a glance
Sickle cell disease (SCD) is a group of inherited blood disorders associated with severe pain and complications that can affect the entire body. This page provides information on SCD and priapism (painful erection of the penis).
![Exterior of an emergency department.](/sickle-cell/media/images/emergencysigns.jpg)
Overview
Sickled red blood cells in the penis can cause a persistent and often painful erection of the penis, known as priapism. Priapism can be considered major, with episodes lasting four hours or more, or stuttering, with recurrent episodes lasting a few minutes to up to three hours. Episodes lasting four hours or more are associated with a greater risk of permanent tissue damage so it’s important to seek medical care immediately.