About Parvovirus B19

Overview

Parvovirus B19 infection usually causes no symptoms or mild illness, such as flu-like symptoms, rashes and joint pains. In individuals with blood disorders or a weakened immune system, infection can cause a low blood count. Infection during pregnancy can sometimes lead to additional complications.

Symptoms

Some people who get infected with this virus will have no symptoms.

When symptoms of parvovirus B19 infection occur, they are usually mild and may include the following:

• Fever
• Headache
• Cough
• Sore throat
• Rashes
• Joint pain

Rashes

The clinical presentation most often associated with parvovirus B19 infection is a red rash on the face, also called a "slapped cheek" rash. This is also known as Fifth Disease (or Erythema Infectiosum). This rash typically appears a few days after the fever or flu-like symptoms. It is more common in children than adults.

Parvovirus B19 infection can also cause a general rash on the chest, back, buttocks, or arms and legs. The rash may be itchy. It usually goes away in 7 to 10 days but can come and go for several weeks. As it starts to go away, it may look lacy.

Joint Pain

Infection with parvovirus B19 can lead to pain and swelling in the joints, called polyarthopathy syndrome. This is more common in adults than children and is most common in women.

Adults may experience joint pain without other symptoms. Joints are affected on both sides, usually in the hands, feet and knees. The joint pain usually lasts 1 to 3 weeks but can last for months or longer. It usually goes away without any long-term problems.

Complications

Parvovirus B19 infection is usually mild for children and adults who are otherwise healthy. However, for some people, it can cause serious health complications affecting the nerves, joints, or blood system.

Parvovirus B19 has been shown to cause a severe drop in blood count (anemia) in some patients with certain blood disorders or with a weakened immune system.

You may be at increased risk for complications from a parvovirus B19 infection if you have one or more of these health conditions:

• Leukemia or other cancers
• Organ transplant
• HIV infection
• Blood disorders such as sickle cell disease and thalassemia

Parvovirus B19 in pregnancy

If you get a parvovirus B19 infection during pregnancy, the virus could spread to the baby. This is not common but could cause a miscarriage. See 'Parvovirus B19 in Pregnancy' for further information.

Recent data on parvovirus B19 activity in the U.S.

Parvovirus B19 has become more prevalent this year with an increased number of cases in 2024, compared to previous years. Recent MMWR articles demonstrate how certain groups at increased risk from infection have been affected by severe health outcomes.

• Detection of Increased Activity of Human Parvovirus B19 Using Commercial Laboratory Testing of Clinical Samples and Source Plasma Donor Pools — United States, 2024
• Notes from the Field: Human Parvovirus B19 Infections Among Pregnant Persons — Minnesota, January–September 2024
• Notes from the Field: Increase in Diagnoses of Human Parvovirus B19–Associated Aplastic Crises in Children and Adolescents with Sickle Cell Disease — Atlanta, Georgia, December 14, 2023–September 30, 2024

Diagnosis

In special circumstances, your healthcare provider may test your blood for parvovirus antibodies. The test will determine if you are susceptible or possibly immune to parvovirus B19 infection or if you were recently infected.

Talk to your healthcare provider if you have any questions about whether you should get tested.

Treatment

Parvovirus B19 infections are usually mild and will go away on their own. Children and adults who are otherwise healthy usually recover completely.

Treatment usually involves relieving symptoms, such as fever, itching, and joint pain and swelling. For persons who develop a low blood count, treatment may include supportive care, blood products, and other specialized therapies.

See your healthcare provider if:

• You have complications from a parvovirus B19 infection, or
• You are infected while pregnant.