Skin Permeation Calculator

What to know

The skin permeation coefficient (kp) is a measure of the conductance of skin to a particular chemical from a particular vehicle.

Image of a man holdng his arm that has a red skin rash

Overview

The Skin Permeation Calculator estimates the value of kp from an aqueous vehicle using three different models: Frasch, Potts & Guy and Modified Robinson.

Two inputs are required: molecular weight (MW) and the base-10 logarithm of the octanol-water partition coefficient (logKow) of the compound of interest. These models have been optimized based on experimental data compiled by Flynn.

The user may also browse the Flynn data base of experimental kp's. Calculation of the modeled kp will automatically be performed for the chosen chemical.

A downloadable version of the Skin Permeation Calculator is now available. Please click here to download an executable file to your computer.

Clicking on the .jar file will open the calculator on your computer.

Contact

Use the email box below for questions related to the calculator.

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References

Frasch Model - Frasch, H. F. (2002) A random walk model of skin permeation. Risk Anal.22, 265-276

Potts and Guy Model - Potts, R. O., and Guy, R. H. (1992) Predicting skin permeability. Pharm. Res.9, 663-669

Modified Robinson Model - Wilschut, A., ten Berge, W. F., Robinson, P. J., McKone, T. E. (1995) Estimating skin permeation. The Validation of five mathematical skin permeation models. Chemosphere30, 1275-1296

Flynn Data Base - Flynn, G. L. (1990) Physicochemical determinants of skin absorption. IN: Garrity, TR, Henry, CJ (Eds) Principles of route-to route extrapolation for risk assessment. Elsevier, New York, pp 93-127.

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Content Source:
; National Institute for Occupational Safety and Health