An official website of the United States government
Ammonium sulfamate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 7773-06-0
NIOSH REL: 10 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA
Current OSHA PEL:15 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA
1989 OSHA PEL: 10 mg/m3 (total dust) TWA, 5 mg/m3 (respirable dust) TWA
1993-1994 ACGIH TLV 10 mg/m3 TWA
Description of substance: Colorless to white crystalline, odorless solid.
LEL: Noncombustible Solid
Original (SCP) IDLH: 5,000 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the rat intraperitoneal LDLO of 800 mg/kg cited by NIOSH [1976] from Ambrose [1943]. This compound has a low toxicity.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived Value |
|---|---|---|---|---|---|---|
| Rat | Ball 1956 | oral | 2,000 | —– | 14,000 mg/m3 | 1,400 mg/m3 |
| Mouse | Gig Tr Prof Zabol 1963 | oral | 3,100 | —– | 21,700 mg/m3 | 2,170 mg/m3 |
| Rat | Lehman 1951 | oral | 3,900 | —– | 27,300 mg/m3 | 2,730 mg/m3 |
| Mouse | Lehman 1951 | oral | 5,760 | —– | 40,320 mg/m3 | 4,032 mg/m3 |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 1,500 mg/m3 Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for ammonium sulfamate. Therefore, the revised IDLH for ammonium sulfamate is 1,500 mg/m3 based on the acute oral toxicity data in animals [Ball 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
REFERENCES:
- Ambrose AM [1943]. Studies of the physiological effects of sulfamic acid and ammonium sulfamate. J Ind Hyg Toxicol 25:26.
- Ball WL [1956]. Threshold limits for pesticides. AMA Arch Ind Health 14:178-185.
- Gig Tr Prof Zabol [1963]; 7(5):56-57 (in Russian).
- Lehman AJ [1951]. Chemicals in foods: a report to the Association of Food and Drug Officials on current developments. Part II. Pesticides. Q Bulletin Assoc Food Drug Off U.S. 15(4):122-125.
- NIOSH [1976]. WO61250. Sulfamic acid, monoammonium salt. In: Registry of Toxic Effects of Chemical Substances (RTECS) 1976 ed. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 1111.