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1,1-Dichloro-1-nitroethane
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 594–72–9
NIOSH REL: 2 ppm (10 mg/m3) TWA
Current OSHA PEL: 10 ppm (60 mg/m3) CEILING
1989 OSHA PEL: 2 ppm (10 mg/m3) TWA
1993-1994 ACGIH TLV: 2 ppm (12 mg/m3) TWA
Description of Substance: Colorless liquid with an unpleasant odor.
LEL:. . Unknown
Original (SCP) IDLH: 150 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the study by Machle et al. [1945] in which autopsies on animals exposed to over 170 ppm for over 30 minutes revealed pulmonary edema and hemorrhage, with damage to the heart, liver, and kidneys.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| RabbitG. pig
Rabbit G. pig Rabbit G. pig |
Machle et al. 1945Machle et al. 1945
Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 Machle et al. 1945 |
170170
97 97 52 52 |
———-
—– —– —– —– |
30 min30 min
6 hr 6 hr 18.75 hr 18.75 hr |
170 ppm (1.0)170 ppm (1.0)
223 ppm (2.3) 223 ppm (2.3) 172 ppm (3.33) 172 ppm (3.33) |
17 ppm17 ppm
22 ppm 22 ppm 17 ppm 17 ppm |
Other animal data: Animals have tolerated 25 ppm for 204 hours [ Machle et al. 1945].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 25 ppmBasis for revised IDLH: The revised IDLH for 1,1-dichloro-1-nitroethane is 25 ppm based on acute inhalation toxicity data in animals [Machle et al. 1945]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
REFERENCE:
1. Machle W, Scott EW, Treon JF, Heyroth FF, Kitzmiller KV [1945]. The physiological response of animals to certain chlorinated mononitroparaffins. J Ind Hyg Toxicol 27(4):95-102.