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Glycidol
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 556–52–5
NIOSH REL: 25 ppm (75 mg/m3) TWA
Current OSHA PEL: 50 ppm (150 mg/m3) TWA
1989 OSHA PEL: 25 ppm (75 mg/m3) TWA
1993-1994 ACGIH TLV: 25 ppm (76 mg/m3) TWA
Description of Substance: Colorless liquid.
LEL: . . Unknown
Original (SCP) IDLH: 500 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 450 ppm and the rat 8-hour LC50 of 580 ppm [Hine et al. 1956 cited by ACGIH 1971, and Patty 1963].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| MouseRat | Hine et al. 1956Hine et al. 1956 | 450580 | ———- | 4 hr8 hr | 900 ppm (2.0)1,450 ppm (2.5) | 90 ppm145 ppm |
Other animal data: It has been reported that rats exposed repeatedly to 400 ppm for 7 hours per day, 5 days a week for 10 weeks showed no evidence of cumulative toxicity, only very slight irritation of the eyes, and slight lacrimation and respiratory distress following the first few exposures [Hine et al. 1956].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 150 ppmBasis for revised IDLH: The revised IDLH for glycidol is 150 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. |
REFERENCES:
1. ACGIH [1971]. Glycidol. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 121-122.
2. Hine CH, Kodama JS, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
3. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1635.