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Dinitro-o-cresol
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number; 534-52-1
NIOSH REL: 0.2 mg/m3 TWA [skin]
Current OSHA PEL: 0.2 mg/m3 TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.2 mg/m3 TWA [skin]
Description of Substance: Yellow, odorless solid.
LEL:. . Unknown
Original (SCP) IDLH: 5 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Hunter [1969] that 4.7 mg/m3 per day caused the following symptoms in a factory worker: fever, weight loss, a 400% rise in the basal rate of metabolism, rapid pulse, rapid respiration, profuse sweating, shortness of breath, and cough [McDonald 1943]. It is obvious that the chosen IDLH has been set conservatively, but no other quantitative data are available on which to base an IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50 | LCLo | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| Cat | Burkatskaya 1965 | LC33: 40 mg/m3 | —– | 4 hr | 80 mg/m3 (2.0) | 8.0 mg/m3 |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RatCat
Mouse Rabbit G. pig Rat |
Colliot 1972DeCeaurriz et al. 1981
MacEwen and Vernot 1972 Popov and Vrochinsky 1976 Popov and Vrochinsky 1976 Spencer et al. 1948 |
oraloral
oral oral oral oral |
750
21 24.6 24.6 31 |
———-
—– —– —– —– |
49 mg/m3350 mg/m3
147 mg/m3 172 mg/m3 172 mg/m3 217 mg/m3 |
4.9 mg/m335 mg/m3
15 mg/m3 17 mg/m3 17 mg/m3 22 mg/m3 |
Human data: An exposure of 4.7 mg/m3 per day resulted in fever, a basal metabolic rate of 400, rapid pulse and respiration, profuse sweating, shortness of breath, and cough [Fairhall 1957]. A single oral dose 75 mg produced no toxic effects in five volunteers [Harvey et al. 1951]. [Note: An oral dose of 75 mg is equivalent to a worker being exposed to 50 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
| Revised IDLH: 5 mg/m3 [Unchanged]Basis for revised IDLH: Based on acute toxicity data in humans [Fairhall 1957; Harvey et al. 1951] and animals [Colliot 1972], the original IDLH for dinitro-o-cresol (5 mg/m3) is not being revised at this time. |
REFERENCES:
1. Burkatskaya EN [1965]. Maximum permissible concentration of dinitro-o-cresol in air. Gig Tr Prof Zabol 30:34-37 (in Russian).
2. Colliot F [1972]. Intérêt présenté par l’acétate de dinoterbe pour le traitement d’hiver des arbres fruitiers et de la vigne. Defensi des Vegetaux 26:69-84 (in French).
3. DeCeaurriz JC, Micillino JC, Bonnet P, Guenier JP [1981]. Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett 9(4):137-143.
4. Fairhall LT [1957]. Industrial toxicology. 2nd ed. Baltimore, MD: Williams & Wilkins Company, p. 230.
5. Harvey DG, Bidstrup PL, Bonnell JAL [1951]. Poisoning by dinitro-ortho-cresol. Some observations on the effects of dinitro-ortho-cresol administered by mouth to human volunteers. Br J Med 2:13-15.
6. Hunter D [1969]. Dinitro-ortho-cresol. In: The diseases of occupations. 4th ed. Boston, MA: Little, Brown and Company, pp. 559-567.
7. MacEwen JD, Vernot EH [1972]. Toxic Hazards Research Unit annual report: 1972. Wright-Patterson Air Force Base, OH: Air Force Systems Command, Aerospace Medical Division, Aerospace Medical Research Laboratory Report, AMRL-TR-72-62.
8. McDonald JM [1943]. Industrial hygiene in wartime Baltimore. Baltimore Health News 20(9):169-170.
9. Popov TA, Vrochinsky KK [1976]. Materials on substantiation of the threshold of DNOC in water bodies. Gig Sanit 41(6):12-15 (in Russian).
10. Spencer HC, Rowe VK, Adams EM, Irish DD [1948]. Toxicological studies on laboratory animals of certain alkyldinitrophenols used in agriculture. J Ind Hyg Toxicol 30:10-28.