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Isopropyl glycidyl ether
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 4016–14–2
NIOSH REL: 50 ppm (240 mg/m3) 15-minute CEILING
Current OSHA PEL: 50 ppm (240 mg/m3) TWA
1989 OSHA PEL: 50 ppm (240 mg/m3) TWA, 75 ppm (360 mg/m3) STEL
1993-1994 ACGIH TLV: 50 ppm (238 mg/m3) TWA, 75 ppm (356 mg/m3) STEL
Description of substance: Colorless liquid.
LEL: . . Unknown
Original (SCP) IDLH: 1,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse 4-hour LC50 of 1,500 ppm and the rat 8-hour LC50 of 1,100 ppm [Hine et al. 1956 cited by Patty 1963].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
|---|---|---|---|---|---|---|
| MouseRat | Hine et al. 1956Hine et al. 1956 | 1,5001,100 | ———- | 4 hr8 hr | 3,000 ppm (2.0)2,750 ppm (2.5) | 300 ppm275 ppm |
Human data: Workers exposed to 400 ppm have suffered irritation of the eyes and respiratory tract [Hine et al. 1956].
| Revised IDLH: 400 ppmBasis for revised IDLH: The revised IDLH for isopropyl glycidyl ether is 400 ppm based on acute inhalation toxicity data in workers [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers exposed to concentrations above 400 ppm. |
REFERENCES:
1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1638.