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Tetramethyl succinonitrile
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 3333–52–6
NIOSH REL: 3 mg/m3 (0.5 ppm) TWA [skin]
Current OSHA PEL: 3 mg/m3 (0.5 ppm) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 2.8 mg/m3 (0.5 ppm) TWA [skin]
Description of substance: Colorless, odorless solid.
LEL: . Unknown
Original (SCP) IDLH: 5 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1972] that 6 ppm for 30 hours was lethal to rats [Spolyar 1948]. A concentration of 22 ppm is obviously too high to be chosen as the IDLH, because no mice survived a 3.5-hour exposure at this concentration [Hecht and Kimmerle 1956-1957 as quoted by Reinl 1957].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
| Mouse | Hecht &Kimmerle 1956/1957 | —– | 28 | 3 hr | 50 ppm (1.8) | 5.0 ppm |
| Mouse | Hecht &Kimmerle 1956/1957 | LC100: 22 | —– | 3.5 hr | 42 ppm (1.9) | 4.2 ppm |
| Rat | Spolyar 1948 | —– | 6 | 30 hr | 24 ppm (3.91) | 2.4 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | Johannsen &ivinskas 1986 | oral | 38.9 | —– | 48 ppm | 4.8 ppm |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 5 ppm [Unchanged]Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Hecht and Kimmerle 1956-1957], the original IDLH for tetramethyl succinonitrile (5 ppm) is not being revised at this time. |
REFERENCES:
1. ACGIH [1972]. Tetramethyl succinonitrile. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 254.
2. Harger RN, Hupieu HR [1949]. Toxicity of tetramethyl succinonitrile and the antidotal effects of thiosulphate, nitrile, and barbiturates. Fed Proc 8:205.
3. Hecht G, Kimmerle H [1956/1957]. Toxikologische Untersuchungen uber Tetramethyl-bernsteinsauredinitril. Unpublished investigations (in German). [From Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl-succinic acid dinitrile. Arch Toxikol 16:367-380 (in German).]
4. Johannsen FR, Livinskas GJ [1986]. Subchronic toxicity of tetramethyl succinonitrile. Fundam Appl Toxicol 7:41-48.
5. Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl-succinic acid dinitrile. Arch Toxikol 16:367-380 (in German).
6. Spolyar LW [1948]. Indiana chemists report toxicity of product of Porofor M. Ind Hyg Newsletter 8(10)3.