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Sulfuryl fluoride
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 2699–79–8
NIOSH REL: 5 ppm (20 mg/m3) TWA, 10 ppm (40 mg/m3) STEL
Current OSHA PEL: 5 ppm (20 mg/m3) TWA
1989 OSHA PEL: 5 ppm (20 mg/m3) TWA, 10 ppm (40 mg/m3) STEL
1993-1994 ACGIH TLV: 5 ppm (21 mg/m3) TWA, 10 ppm (42 mg/m3) STEL
Description of substance: Colorless, odorless gas.
LEL: Nonflammable Gas
Original (SCP) IDLH: 1,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the report by Taxay [1966] that less than 5% mortality resulted from exposure of animals for 3 hours to 1,000 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derived value |
|---|---|---|---|---|---|---|
| Rat | Nitschke et al. 1986 | 991 | —– | 4 hr | 1,982 ppm (2.0) | 198 ppm |
| Mouse | Truhaut et al. 1973 | —– | 1,200 | 1 hr | 1,500 ppm (1.25) | 150 ppm |
| Rabbit | Truhaut et al. 1973 | —– | 5,000 | 1 hr | 6,250 ppm (1.25) | 625 ppm |
Other animal data: It has been reported that less than 5% mortality resulted from exposure for 3 hours to 1,000 ppm [Taxay 1966].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 200 ppmBasis for revised IDLH: The revised IDLH for sulfuryl fluoride is 200 ppm based on acute inhalation toxicity data in animals [Nitschke et al. 1986; Truhaut et al. 1973]. |
REFERENCES:
1. Nitschke KD, Albee RR, Mattsson JL, Miller RR [1986]. Incapacitation and treatment of rats exposed to a lethal dose of sulfuryl fluoride. Fundam Appl Toxicol 7:664-670.
2. Taxay EP [1966]. Vikane inhalation. J Occup Med 8:425-426.
3. Truhaut R, Boudene C, Cluet JL [1973]. Toxicite de quelques derives gazeux fluores et oxyfluores du soufre. Arch Mal Prof 34(10-11):581-591 (in French).