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n-Butyl glycidyl ether
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 2426–08–6
NIOSH REL: 5.6 ppm (30 mg/m3) 15-minute CEILING
Current OSHA PEL: 50 ppm (270 mg/m3) TWA
1989 OSHA PEL: 25 ppm (135 mg/m3) TWA
1993-1994 ACGIH TLV: 25 ppm (133 mg/m3) TWA
Description of Substance: Colorless liquid with an irritating odor.
LEL: . . Unknown
Original (SCP) IDLH: 3,500 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that the mouse 4-hour LC50 was greater than 3,500 ppm [Hine et al. 1956].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| MouseRat | Hine et al. 1956Hine et al. 1956 | >3,5001,030 | ———- | 4 hr8 hr | >7,000 ppm (2.0)2,575 ppm (2.5) | >700 ppm258 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| MouseRat | Hine et al. 1956Smyth et al. 1962 | oraloral | 1,5302,050 | ———- | 1,980 ppm2,652 ppm | 198 ppm265 ppm |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 250 ppmBasis for revised IDLH: The revised IDLH for n-butyl glycidyl ether is 250 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
REFERENCES:
1. ACGIH [1971]. n-Butyl glycidyl ether (BGE). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 33.
2. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.