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Dimethylphthalate
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 131–11–3
NIOSH REL: 5 mg/m3 TWA
Current OSHA PEL: 5 mg/m3 TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 mg/m3 TWA
Description of Substance: Colorless, oily liquid with a slight, aromatic odor.
LEL(@358 F): 0.9% (10% LEL(@358 F), 11,300 mg/m3)
Original (SCP) IDLH: 9,300 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Spector [1956] that 9,300 mg/m3 was a lethal concentration for the cat [Eller 1937].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50 | LCLo | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| Cat | Eller, 1937 | —– | 9,630 mg/m3 | 6 hr | 22,149 mg/m3 (2.3) | 2,215 mg/m3 |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RatRabbit
G. pig Rat Mouse Rabbit G. pig |
Lehman 1955Lehman 1955
Lehman 1955 Timofeevskaia et al. 1963 Timofeevskaia et al. 1963 Woodard and Hagan 1948 Woodard and Hagan 1948 |
oraloral
oral oral oral oral oral |
6,9001,000
2,400 6,800 6,800 4,400 2,400 |
———-
—– —– —– —– —– |
48,300 mg/m37,000 mg/m3
16,800 mg/m3 47,600 mg/m3 47,600 mg/m3 30,800 mg/m3 16,800 mg/m3 |
4,830 mg/m3700 mg/m3
1,680 mg/m3 4,760 mg/m3 4,760 mg/m3 3,080 mg/m3 1,680 mg/m3 |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 2,000 mg/m3Basis for revised IDLH: The revised IDLH for dimethylphthalate is 2,000 mg/m3 based on acute inhalation toxicity data in animals [Eller 1937]. [Note: Due to its low volatility, this concentration could only be reached at elevated temperatures or if the liquid droplets become airborne as in a mist.] |
REFERENCES:
1. Eller [1937]. Doctoral dissertation. Wurzburg, Germany: Julius Maximillian University (in German). [From Spector WS, ed. [1956]. Handbook of toxicology. Vol. I. Acute toxicities. Philadelphia, PA: W.B. Saunders Company, pp. 334-335.]
2. Lehman AJ [1955]. Insect repellents. Q Bulletin Assoc Food Drug Off U.S. 19:87-90.
3. Spector WS, ed. [1956]. Handbook of toxicology. Vol. I. Acute toxicities. Philadelphia, PA: W.B. Saunders Company, pp. 334-335.
4. Timofeevskaia LA, Ivanova NI, Balinina ES [1963]. Toxicology of o-phthalic acid esters and hygienic reglamentation. Gig Tr Prof Zabol 24(3):25-27 (in Russian).
5. Woodard G, Hagan EC [1948]. Toxicological investigations of compounds proposed for use as insect repellents. B. Acute oral toxicity. J Pharmacol Exp Ther 93:26-39.