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N,N-Dimethylaniline
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 121–69–7
NIOSH REL: 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]
Current OSHA PEL: 5 ppm (25 mg/m3) TWA [skin]
1989 OSHA PEL: 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]
1993-1994 ACGIH TLV: 5 ppm (25 mg/m3) TWA, 10 ppm (50 mg/m3) STEL [skin]
Description of Substance: Pale yellow, oily liquid with an amine-like odor.
LEL:. . Unknown
Original (SCP) IDLH: 100 ppm
Basis for original (SCP) IDLH: No quantitative data on acute inhalation toxicity are available for dimethylaniline. Because the TLV for dimethylaniline is based on an analogy with aniline [ACGIH 1971], the chosen IDLH is also based on an analogy with aniline, which has an IDLH of 100 ppm.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| Rat | Slusar et al. 1972 | —– | 50 | 4 hr | 100 ppm (2.0) | 10 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | Smyth et al. 1962 | oral | 1,410 | —– | 1,958 ppm | 196 ppm |
Human data: N,N-Dimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect — notably, methemoglobinemia [Clayton and Clayton 1981]. It has been reported that 50 mg/kg is the lethal oral dose [Hall 1969]. [Note: An oral dose of 50 mg/kg is equivalent to a 70-kg worker being exposed to 2,333 mg/m3 (463 ppm) for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
| Revised IDLH: 100 ppm [Unchanged]Basis for revised IDLH: Based on an analogy with aniline [Clayton and Clayton 1981] which has an IDLH of 100 ppm and to acute oral toxicity data in humans [Hall 1969], the original IDLH for N,N-dimethylaniline (100 ppm) is not being revised for at this time. |
REFERENCES:
1. ACGIH [1971]. Dimethylaniline (n-dimethylaniline). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 89.
2. Clayton GD, Clayton FE, eds. [1981]. Patty’s industrial hygiene and toxicology. 3rd rev. ed. Vol. 2A. Toxicology. New York: John Wiley & Sons, Inc., pp. 2416-2454.
3. Hall R [1969]. Adhesives. Washington DC: National Clearinghouse for Poison Control Centers Bulletin, p. 5. Jan/Feb, 1969.
4. Slusar MP, Zvezday VI, Kolodub FA [1972]. Hygienic standardization of N,N-dimethylaniline in the air of industrial premises. Gig Sanit 37(4):35-37 (in Russian).
5. Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA [1962]. Range-finding toxicity data: list VI. Am Ind Hyg Assoc J 23:95-107.