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Cyclohexanol
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–93–0
NIOSH REL: 50 ppm (200 mg/m3) TWA [skin]
Current OSHA PEL: 50 ppm (200 mg/m3) TWA
1989 OSHA PEL: 50 ppm (200 mg/m3) TWA [skin]
1993-1994 ACGIH TLV: 50 ppm (206 mg/m3) TWA [skin]
Description of Substance: Sticky solid or colorless to light-yellow liquid (above 77 F) with a camphor-like odor.
LEL: . . Unknown
Original (SCP) IDLH: 3,500 ppm
Basis for original (SCP) IDLH: No acute inhalation toxicity data are available on which to base an IDLH for cyclohexanol. The chosen IDLH, therefore, has been estimated from the rabbit oral LD50 of 2.2 to 2.6 g/kg [Treon et al. 1943 cited in Browning 1965]. The chosen IDLH of 3,500 ppm (14.3 g/m3) is probably conservative, because the lower end of the range of the LD50 values (i.e., 2.2 g/kg) has been used to estimate the IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RatRabbit | Bar and Griepentrog 1967Treon et al. 1943 | oraloral | 2,0602,200-2,600 | ———- | 3,458 ppm3,693-4,365 ppm | 346 ppm369-437 ppm |
Human data: The estimated acceptable concentration for 8 hours was reported in volunteers to be less than 100 ppm [Nelson et al. 1943].
| Revised IDLH: 400 ppmBasis for revised IDLH: The revised IDLH for cyclohexanol is 400 ppm based on acute oral toxicity data in animals [Bar and Griepentrog 1967; Treon et al. 1943]. |
REFERENCES:
1. Bar F, Griepentrog F [1967]. Die situation in der gesundheitlichen beurteilung der aromaliscerungsmittel für lebensmittel. Med Ernahr 8:282-251. [From ACGIH [1991]. Cyclohexanol. In: Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 357-358.]
2. Browning E [1965]. Toxicity and metabolism of industrial solvents. New York, NY: Elsevier Publishing Company, p. 387.
3. Nelson KW, Ege JF, Ross M, Woodman LE, Silverman L [1943]. Sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 25(7):282-285.
4. Treon JF, Crutchfield WE Jr, Kitzmiller KV [1943]. The physiological response of rabbits to cyclohexane, methyl cyclohexane, and certain derivatives of these compounds. I. Oral administration and cutaneous application. J Ind Hyg Toxicol 25(6):199-214.