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Diisobutyl ketone
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–83–8
NIOSH REL: 25 ppm (150 mg/m3) TWA
Current OSHA PEL: 50 ppm (290 mg/m3) TWA
1989 OSHA PEL: 25 ppm (150 mg/m3) TWA
1993-1994 ACGIH TLV: 25 ppm (145 mg/m3) TWA
Description of Substance: Colorless liquid with a mild, sweet odor.
LEL(@200 F): 0.8% (10% LEL(@200 F), 800 ppm)
Original (SCP) IDLH: 2,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that “breathing saturated vapors in air killed 1 of 6 animals in 8 hours; breathing 2,000 ppm for 8 hours killed 5 of 6 animals. Breathing 1,000 ppm for 8 hours produced illness but no deaths.” This is the only useful data available on which to base the IDLH for this substance.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| RatRat | Smyth et al. 1949Smyth et al. 1949 | —–2,000 | 2,000—– | 4 hr8 hr | 4,000 ppm (2.0)5,000 ppm (2.5) | 400 ppm500 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| RatMouse
Rat |
NPIRI 1974Shell 1961
Smyth et al. 1949 |
oraloral
oral |
5,7501,416
5,800 |
———-
—– |
6,799 ppm1,674 ppm
6,858 ppm |
680 ppm167 ppm
686 ppm |
Human data: It has been reported that a 3-hour exposure at 50 or 100 ppm caused slight irritation to the eyes, nose, and throat [Smyth et al. 1949].
| Revised IDLH: 500 ppmBasis for revised IDLH: The revised IDLH for diisobutyl ketone is 500 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949]. |
REFERENCES:
1. Carpenter CP, Pozzani UC, Weil CS [1953]. Toxicity and hazard of diisobutyl ketone vapors. AMA Arch Ind Hyg Occup Med 8:377-381.
2. NPIRI [1974]. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Vol. 1. Organic solvents. Bethlehem, PA: National Printing Ink Research Institute, p. 23.
3. Shell [1961]. Unpublished report. Shell Chemical Company, p. 4.
4. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol 31:60-62.
5. UCC [1971]. Toxicology studies: diisobutyl ketone. New York, NY: Union Carbide Corporation.