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Diisopropylamine
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 108–18–9
NIOSH REL: 5 ppm (20 mg/m3) TWA [skin]
Current OSHA PEL: 5 ppm (20 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 5 ppm (21 mg/m3) TWA [skin]
Description of Substance: Colorless liquid with an ammonia- or fish-like odor.
LEL:. . 1.1% (10% LEL, 1,100 ppm)
Original (SCP) IDLH: 1,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that a 4-hour exposure to 1,000 ppm killed 2 of 6 rats. Patty [1963] reported the same information [Smyth et al. 1954].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| RatMouse
Rat Rabbit G. pig Cat |
Izmerov et al. 1982Izmerov et al. 1982
Smyth et al. 1954 Treon et al. 1949 Treon et al. 1949 Treon et al. 1949 |
1,1401,000
LC33: 1,000 —– —– —– |
———-
—– 2,207 2,207 2,207 |
2 hr2 hr
4 hr 2.5 hr 80 min 72 min |
1,824 ppm (1.6)1,596 ppm (1.6)
2,000 ppm (2.0) 3,752 ppm (1.7) 3,090 ppm (1.4) 2,869 ppm (1.3) |
182 ppm160 ppm
200 ppm 375 ppm 309 ppm 287 ppm |
Human data: Complaints of nausea, headache, and temporary dimness in vision were reported in workers 2 to 3 hours following several 5- to 10-minute exposures to about 176 ppm; concentrations otherwise during the workshift averaged about 24 to 48 ppm [Treon et al. 1949]
| Revised IDLH: 200 ppmBasis for revised IDLH: The revised IDLH for diisopropylamine is 200 ppm based on acute inhalation toxicity data in workers [Treon et al. 1949] and animals [Izmerov et al. 1982; Smyth et al. 1954]. |
REFERENCES:
1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 54.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 2044.
3. Smyth HF Jr, Carpenter CP, Weil CS, Pozzani UC [1954]. Range-finding toxicity data: list V. AMA Arch Ind Hyg Occup Med 10:61-68.
4. Treon JF, Sigmon H, Kitzmiller KV, Heyroth FF [1949]. The physiological response of animals to respiratory exposure to the vapors of diisopropylamine. J Ind Hyg Toxicol 31:142-145.
5. UCC [1971]. Toxicology studies: diisopropyl amine. New York, NY: Union Carbide Corporation.