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Quinone
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 106–51–4
NIOSH REL: 0.4 mg/m3 (0.1 ppm) TWA
Current OSHA PEL: 0.4 mg/m3 (0.1 ppm) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 0.44 mg/m3 (0.1 ppm) TWA
Description of substance: Pale-yellow solid with an acrid, chlorine-like odor.
LEL: . . . Unknown
Original (SCP) IDLH: 300 mg/m3
Basis for original (SCP) IDLH: The chosen IDLH is based on the mouse LCLO of 320 mg/m3 [Zabolevanii 1962 cited by NIOSH 1976]. No other data on acute inhalation toxicity are available on which to base the IDLH.
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA:
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| MammalMouse
Mouse Rat Rat Rat |
Izmerov et al. 1982Marquardt et al. 1947
Serif & Seymour 1963 Tomchin et al. 1978 Woodward et al. 1949 Woodward et al. 1949 |
s.c.s.c.
i.p. ? oral i.v. |
29693.8
8.5 5.6 130 25 |
———-
—– —– —– —– |
2,072 mg/m3657 mg/m3
60 mg/m3 39 mg/m3 910 mg/m3 175 mg/m3 |
207 mg/m366 mg/m3
6.0 mg/m3 3.9 mg/m3 91 mg/m3 18 mg/m3 |
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 100 mg/m3Basis for revised IDLH: No inhalation toxicity data are available on which to base an IDLH for quinone. Therefore, the revised IDLH for quinone is 100 mg/m3 based on acute oral toxicity data in animals [Woodward et al. 1949]. This may be a conservative value due to the lack of relevant acute toxicity data for workers. |
REFERENCES:
1. Izmerov NF, Sanotsky IV, Sidorov KK [1982]. Toxicometric parameters of industrial toxic chemicals under single exposure. Moscow, Russia: Centre of International Projects, GKNT, p. 25.
2. Marquardt P, Koch R, Aubert J-P [1947]. Die toxizität der ein-, zwei- und dreiwertigen phenole. Zeit Ges Med Gren 2:333 (in German).
3. NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.
4. Serif GS, Seymour LE [1963]. Catabolism and excretion of the antithyroid substance, diacetyl-2,6-diiodohydroquinone. Biochem Pharmacol 12:885-891.
5. Tomchin AB, Aleksandrova AE, Vinogradov VM [1978]. Structure and anti-hypoxic activity of alpha-dicarbonyl compounds and their derivatives. Farmakol Toxsikol 41(4):482-491 (in Russian).
6. Woodward G, Hagan EC, Radomski JL [1949]. Toxicity of hydroquinone for laboratory animals. Fed Proc 8:348.
7. Zabolevanii Prof. Khim. Etiol. Sb. [1962]. Prom Toksikol Klin, p. 137 (in Russian). [From NIOSH [1976]. DK26250. p-Benzoquinone. In: Registry of toxic effects of chemical substances, 1976 ed. Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Center for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 76-191, p. 202.]