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Ethyl butyl ketone
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 106–35–4
NIOSH REL: 50 ppm (230 mg/m3) TWA
Current OSHA PEL: 50 ppm (230 mg/m3) TWA
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 50 ppm (234 mg/m3) TWA
Description of Substance: Colorless liquid with a powerful, fruity odor.
LEL:. . Unknown
Original (SCP) IDLH: 3,000 ppm
Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty [1963] and Deichmann and Gerarde [1969] that 0 rats died following a 4-hour exposure to 2,000 ppm, but 6 of 6 rats died following a 4-hour exposure to 4,000 ppm [Smyth et al. 1949].
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| Rat | Smyth et al. 1949 | LC100: 4,000 | —– | 4 hr | 8,000 ppm (2.0) | 800 ppm |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | Smyth et al. 1949 | oral | 2,760 | —– | 4,067 ppm | 408 ppm |
Other animal data: It has been reported that rats survived a 4-hour exposure to 2,000 ppm [Smyth et al. 1949].
Human data: None relevant for use in determining the revised IDLH.
| Revised IDLH: 1,000 ppmBasis for revised IDLH: The revised IDLH for ethyl butyl ketone is 1,000 ppm based on acute inhalation toxicity data in animals [Smyth et al. 1949]. |
REFERENCE:
1. Deichmann WB, Gerarde HW [1969]. Table 50. Toxicity of ketones. In: Toxicology of drugs and chemicals. New York, NY: Academic Press, Inc., p. 736.
2. Patty FA, ed. [1963]. Industrial hygiene and toxicology. 2nd rev. ed. Vol. II. Toxicology. New York, NY: Interscience Publishers, Inc., p. 1741.
3. Smyth HF Jr, Carpenter CP, Weil CS [1949]. Range-finding toxicity data: list III. J Ind Hyg Toxicol 31:60-62.