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2-Diethylaminoethanol
May 1994
Immediately Dangerous to Life or Health Concentrations (IDLH)
CAS number: 100–37–8
NIOSH REL: 10 ppm (50 mg/m3) TWA [skin]
Current OSHA PEL: 10 ppm (50 mg/m3) TWA [skin]
1989 OSHA PEL: Same as current PEL
1993-1994 ACGIH TLV: 10 ppm (48 mg/m3) TWA [skin]
Description of Substance: Colorless liquid with a nauseating, ammonia-like odor.
LEL:. . Unknown
Original (SCP) IDLH: 500 ppm
Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for diethylaminoethanol. The chosen IDLH is based on the following statements by Cornish [1965]: “exposure of rats to 500 ppm, 6 hours daily for 5 days, resulted in severe weight loss and high mortality. Daily exposure at 200 ppm resulted in the death of 7 of 50 rats during the first month. A single human exposure for a few seconds to a level well below 200 ppm resulted in nausea and vomiting.”
Short-term exposure guidelines: None developed
ACUTE TOXICITY DATA
Lethal concentration data:
| Species | Reference | LC50(ppm) | LCLo(ppm) | Time | Adjusted 0.5-hrLC (CF) | Derivedvalue |
|---|---|---|---|---|---|---|
| RatMouse | Lomonova 1970Lomonova 1970 | 9241,027 | ———- | 4 hr? | 1,848 ppm (2.0)? | 185 ppm? |
Lethal dose data:
| Species | Reference | Route | LD50(mg/kg) | LDLo(mg/kg) | Adjusted LD | Derived value |
|---|---|---|---|---|---|---|
| Rat | Smyth and Carpenter 1944 | oral | 1,300 | —– | 1,869 ppm | 187 ppm |
Human data: A very short exposure (<30 seconds) to a concentration estimated to be less than 100 ppm has resulted in nausea and vomiting within 5 minutes; other persons in the same room also complained of the nauseating odor but did not become ill [Cornish 1965].
| Revised IDLH: 100 ppm Basis for revised IDLH: The revised IDLH for 2-diethylaminoethanol is 100 ppm based on acute inhalation toxicity data in humans [Cornish 1965]. |
REFERENCES:
1. Cornish HH [1965]. Oral and inhalation toxicity of 2-diethylaminoethanol. Am Ind Hyg Assoc J 26:479-484.
2. Lomonova GV [1970]. Toxicology data on dimethylethanolamine and diethylethanolamine. Gig Tr Prof Zabol 14(11):52-53 (translated).
3. Smyth HF Jr, Carpenter CP [1944]. The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 26:269-273.