Sodium borate, decahydrate

RTECS #

VZ2275000

CAS #

1303-96-4; 1344-90-7; 12447-40-4; 61028-24-8
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

381.42

Molecular Formula

B₄O₇·2Na·1₀H₂O

Synonyms

Antipyonin
Borascu
Borates, tetra, sodium salt, decahydrate (ACGIH)
Borates, tetra, sodium salts (decahydrate)
Borax (8CI)
Borax decahydrate
Boricin
Disodium tetraborate decahydrate
Gertley borate
Jaikin
Neobor
Sodium biborate decahydrate
Sodium pyroborate decahydrate
Sodium tetraborate decahydrate
Solubor
Three Elephant
Tronabor

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/Drosophila melanogaster	714 ppm	SOGEBZ 10,601,1974
specific locus test	oral/Drosophila melanogaster	714 ppm	SOGEBZ 10,601,1974

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	70 gm/kg (90D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 23,351,1972
oral/rat	70 gm/kg (90D prior to copulation)	Reproductive: Maternal effects: Ovaries, fallopian tubes	TXAPA9 23,351,1972
oral/rat	37 gm/kg (multigenerations)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	TXAPA9 23,351,1972
oral/Dog	70 gm/kg (26W male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 23,351,1972

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 48 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
intraperitoneal/mouse	lethal dose (50 percent kill): 2711 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle contraction or spasticity	AIPTAK 143,144,1963
intravenous/mouse	lethal dose (50 percent kill): 1320 mg/kg		14KTAK -,693,1964
oral/Dog	lowest published lethal dose: 3 gm/kg		HBAMAK 4,1289,1935
oral/guinea pig	lethal dose (50 percent kill): 5330 mg/kg		14KTAK -,693,1964
oral/infant	lowest published lethal dose: 1 gm/kg		PCOC** -,144,1966
oral/man	lowest published lethal dose: 709 mg/kg	Behavioral: Convulsions or effect on seizure threshold Cardiac: Change in rate Gastrointestinal: Nausea or vomiting	JAMAAP 76,378,1921
oral/mouse	lethal dose (50 percent kill): 2 gm/kg		14KTAK -,693,1964
oral/rat	lethal dose (50 percent kill): 2660 mg/kg		FMCHA2 -,C48,1991
subcutaneous/rabbit	lowest published lethal dose: 150 mg/kg		HBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 35 gm/kg/90D- continuous	Liver: Changes in liver weight Endocrine: Changes in thyroid weight Related to Chronic Data: Changes in testicular weight	TXAPA9 23,351,1972
oral/rat	lowest published toxic dose: 70 gm/kg/90D- continuous	Brain and Coverings: Changes in brain weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TXAPA9 23,351,1972
oral/rat	lowest published toxic dose: 377 gm/kg/2Y- continuous	Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TXAPA9 23,351,1972
oral/rat	lowest published toxic dose: 18524 mg/kg/70D- continuous	Endocrine: Changes in spleen weight Blood: Other changes Related to Chronic Data: Changes in testicular weight	BECTA6 25,782,1980

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 mg/m³;short term exposure limit 6 mg/m³ (inhal)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		REPTED 29,10,2010

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,90,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 2 mg/m³, short term exposure limit 6 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 mg/m³, skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 mg(B)/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 2 mg/m³, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.2 mg/m2, MAC(short term exposure limit) 2 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	time-weighted average 2 mg/m³;short term exposure limit 5 mg/m³, Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 5 mg/m³, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BORATES, decahydrate-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code T1956; Number of Industries 196; Total Number of Facilities 29342; Number of Occupations 132; Total Number of Employees Exposed 442072; Total Number of Female Employees Exposed 88646
National Occupational Exposure Survey 1983	Hazard Code X6986; Number of Industries 3; Total Number of Facilities 143; Number of Occupations 4; Total Number of Employees Exposed 1615; Total Number of Female Employees Exposed 53

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health