2-Propyn-1-ol

RTECS #

UK5075000

CAS #

107-19-7
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

56.07

Molecular Formula

C₃H₄O

Synonyms

1-Propyne-3-ol
2-Propynyl alcohol
Acetylene carbinol
Agrisynth PA
Ethynylcarbinol
Methanol, ethynyl-
Propargyl alcohol
Propargyl alcohol (ACGIH:OSHA)
RCRA waste number P102

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	ovary/hamster	400 µmol/L	MUREAV 320,273,1994
Cytogenetic Analysis	ovary/hamster	10 mmol/L/16H (+/-enzymatic activation step)	HPV358 -,-,2003
mutation in microorganisms	/Salmonella typhimurium	10 µmol/plate (+enzymatic activation step)	UNMI** DA85-04850

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 3 gm/m³		GTPZAB 32(10),25,1988
inhalation/mouse	lethal concentration (50 percent kill): 2000 mg/m³/2H	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea	TPKVAL 8,97,1966
inhalation/mouse	Lowest published lethal concentration: 1.25 gm/m³/2H	Vascular: Other changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Dyspnea	TPKVAL 8,97,1966
inhalation/mouse	lethal concentration (50 percent kill): 1.75 gm/m³/2H		TPKVAL 8,97,1966
inhalation/mouse	lethal concentration (50 percent kill): 1750 mg/m³	Lung, Thorax, or Respiration: Respiratory depression Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,122,1984
inhalation/rat	lethal concentration (50 percent kill): 1800 mg/m³	Lung, Thorax, or Respiration: Respiratory depression Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,122,1984
inhalation/rat	lethal concentration (50 percent kill): 873 ppm/2H		GAFCC*
inhalation/rat	lethal concentration (50 percent kill): 1.8 gm/m³/2H	Gastrointestinal: Necrotic changes Gastrointestinal: Other changes Liver: Fatty liver degeneration	TPKVAL 8,97,1966
inhalation/rat	lethal concentration (50 percent kill): 1040 ppm/1H		HPV358 -,-,2003
inhalation/rat	Lowest published lethal concentration: 1.25 gm/m³/2H	Peripheral Nerve and Sensation: Fasciculations Behavioral: Somnolence (general depressed activity) Vascular: Other changes	TPKVAL 8,97,1966
ocular/rabbit	lowest published toxic dose: 100 pph	Eye: Lacrimation Eye: Conjunctiva irritation Eye: Other eye effects	TPKVAL 8,97,1966
oral/guinea pig	lethal dose (50 percent kill): 60 mg/kg		DTLVS* 4,346,1980
oral/mammal (species unspecified)	lethal dose (50 percent kill): 50 mg/kg		GTPZAB 32(10),25,1988
oral/mouse	lethal dose (50 percent kill): 50 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,122,1984
oral/mouse	lethal dose (50 percent kill): 50 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Blood: Hemorrhage	TPKVAL 8,97,1966
oral/rat	lethal dose (50 percent kill): 20 mg/kg		38MKAJ 2C,4672,1982
oral/rat	lethal dose (50 percent kill): 55 mg/kg	Endocrine: Other changes Blood: Hemorrhage	HPV358 -,-,2003
oral/rat	lethal dose (50 percent kill): 55 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,122,1984
skin/rabbit	lethal dose (50 percent kill): 16 mg/kg	Skin: After systemic exposure: Dermatitis, other	38MKAJ 2C,4672,1982
skin/rabbit	lethal dose (50 percent kill): 88 mg/kg		HPV358 -,-,2003
skin/rabbit	lowest published lethal dose: 15 mg/kg		HPV358 -,-,2003
subcutaneous/rabbit	lowest published lethal dose: 25 mg/kg		BDBU** -,-,1930
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 53 mg/kg		GISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 100 mg/m³/4H/60D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,122,1994
inhalation/mammal (species unspecified)	lowest published toxic concentration: 5 mg/m³/4H/28W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,122,1994
inhalation/mouse	lowest published toxic concentration: 25300 ppb/6H/14D- intermittent	Olfaction: Other olfaction effects	JJATDK 15,207,1995
inhalation/mouse	lowest published toxic concentration: 16 ppm/13W- continuous	Olfaction: Other olfaction effects Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	HPV358 -,,2003
inhalation/mouse	lowest published toxic concentration: 230 mg/m³/2H/3W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 8,97,1966
inhalation/mouse	lowest published toxic concentration: 0.25 gm/m³/10D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 8,97,1966
inhalation/rat	lowest published toxic concentration: 0.25 gm/m³/14D- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 8,97,1966
inhalation/rat	lowest published toxic concentration: 0.01 gm/m³/91D- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 8,97,1966
inhalation/rat	lowest published toxic concentration: 0.01 gm/m³/61D- intermittent	Liver: Liver function tests impaired	TPKVAL 8,97,1966
inhalation/rat	lowest published toxic concentration: 32 ppm/90D- continuous	Olfaction: Other olfaction effects Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	HPV358 -,,2003
inhalation/rat	lowest published toxic concentration: 24.6 ppm/90D- continuous	Kidney, Ureter, and Bladder: Changes in kidney weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	HPV358 -,,2003
inhalation/rat	lowest published toxic concentration: 230 mg/m³/2H/3W- intermittent	Brain and Coverings: Recordings from specific areas of CNS Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 8,97,1966
inhalation/rat	lowest published toxic concentration: 7 mg/m³/4H/22W- intermittent	Vascular: BP lowering not characterized in autonomic section Liver: Liver function tests impaired Blood: Changes in leukocyte (WBC) count	TPKVAL 8,97,1966
oral/rat	lowest published toxic dose: 1365 mg/kg/13W- continuous	Liver: Other changes	HPV358 -,,2003
oral/rat	lowest published toxic dose: 4550 mg/kg/13W- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV358 -,,2003

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 539,77,2003

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (2 mg/m³) (skin)	DTLVS* 3,215,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (2.3 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (4.7 mg/m³);KZW 4 ppm (9.4 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (2.3 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (2.5 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (2.3 mg/m³), short term exposure limit 3 ppm (7 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (2 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 2 ppm (4.7 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (2.5 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (2 mg/m³), skin, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (2.3 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (2,3 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 2 ppm (4.7 mg/m³), KZG-week 4 ppm (9.4 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 2 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1 ppm (1 mg/m³), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (2.3 mg/m³);short term exposure limit 3 ppm (7 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1 ppm (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1 ppm (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPARGYL ALCOHOL-air	10H time-weighted average 1 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 62000; Number of Industries 56; Total Number of Facilities 3447; Number of Occupations 38; Total Number of Employees Exposed 54359; Total Number of Female Employees Exposed 19934
National Occupational Hazard Survey 1974	Hazard Code 62000; Number of Industries 7; Total Number of Facilities 471; Number of Occupations 11; Total Number of Employees Exposed 30791

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #97

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health