Phthalic acid, dimethyl ester

RTECS #

TI1575000

CAS #

131-11-3; 64441-70-9
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

194.20

Molecular Formula

C₁₀H₁₀O₄

Synonyms

1,2-Benzenedicarboxylic acid, dimethyl ester
Avolin
Dimethyl 1,2-benzenedicarboxylate
Dimethyl benzene-o-dicarboxylate
Dimethyl benzeneorthodicarboxylate
Dimethyl o-phthalate
Dimethyl phthalate (ACGIH:OSHA)
Dimethylester kyseliny ftalove (Czech)
Dimethylphthalate
DMF (insect repellent)
ENT 262
Fermine
Methyl phthalate
Mipax
NTM
o-Dimethyl phthalate
Palatinol M
Phthalate acid, dimethyl ester
Phthalic acid methyl ester
Phthalsaeuredimethylester (German)
RCRA waste number U102
Repeftal
Solvanom
Solvarone
Unimoll DM

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	119 mg		JPETAB 82,377,1944

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	skin/rat	25 gm/kg/4W- intermittent	FATOAO 40,454,1977
mutation in microorganisms	/Salmonella typhimurium	200 µg/plate (+enzymatic activation step)	JTEHD6 16,61,1985

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	338 mg/kg (5-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	JPMSAE 61,51,1972
intraperitoneal/rat	338 mg/kg (5-15D pregnant)	Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Other developmental abnormalities	JPMSAE 61,51,1972
intraperitoneal/rat	1125 mg/kg (5-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	JPMSAE 61,51,1972
intraperitoneal/rat	1500 mg/kg (3-9D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	JDSCAE 55,696,1972
intraperitoneal/rat	3 mL/kg (3-9D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	EVHPAZ 3,91,1973
oral/rat	35700 mg/kg (6-15D pregnant)	Reproductive: Other effects on female	HPV349 -,-,2001

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, embryonic cells	Inhibitor Concentration (50 percent kill): >500 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 38,41,2017
In Vitro/Human, embryonic cells	Inhibitor Concentration (50 percent kill): >500 µmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TIVIEQ 38,41,2017
In Vitro/Rat, neurons	Inhibitor Concentration (50 percent kill): 7.87 µmol/L/10M	In Vitro Toxicity Studies: Other assays	NRTXDN 40,75,2014
inhalation/cat	Lowest published lethal concentration: 9300 mg/m³/6.5H		14CYAT 2,1905,1963
inhalation/rat	lowest published toxic concentration: 10 mg/m³	Peripheral Nerve and Sensation: Recording from peripheral motor nerve	TPKVAL 15,123,1979
intraperitoneal/mouse	lethal dose (50 percent kill): 1380 mg/kg		IPSTB3 3,93,1976
intraperitoneal/rat	lethal dose (50 percent kill): 3375 µL/kg		JPMSAE 61,51,1972
intraperitoneal/rat	lethal dose (50 percent kill): 30.7 gm/kg		ENTOX* -,422,2005
oral/chicken	lethal dose (50 percent kill): 8500 µL/kg		JPETAB 93,26,1948
oral/Dog	Lethal dose: >1400 mg/kg		EVHPAZ 3,61,1973
oral/guinea pig	lethal dose (50 percent kill): 2400 µL/kg		JPETAB 93,26,1948
oral/mouse	lethal dose (50 percent kill): >30 gm/kg		ENTOX* -,422,2005
oral/mouse	lethal dose (50 percent kill): 6800 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GTPZAB 24(3),25,1980
oral/rabbit	lethal dose (50 percent kill): 4400 µL/kg		JPETAB 93,26,1948
oral/rat	lethal dose (50 percent kill): 6900 mg/kg		HPV349 -,-,2001
oral/rat	lethal dose (50 percent kill): 6800 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GTPZAB 24(3),25,1980
skin/guinea pig	lethal dose (50 percent kill): >10 mL/kg		JPETAB 93,26,1948
skin/rabbit	lethal dose (50 percent kill): >20 mL/kg		38MKAJ 2A,2343,1981
skin/rat	lethal dose (50 percent kill): >4800 mg/kg		85JFAN A154,1983
subcutaneous/mouse	lowest published lethal dose: 6500 mg/kg	Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis	EDWU** -,-,1937
unreported route/guinea pig	lethal dose (50 percent kill): 4800 mg/kg		GTPZAB 32(7),52,1988
unreported route/mouse	lethal dose (50 percent kill): 6800 mg/kg		GTPZAB 32(7),52,1988
unreported route/rat	lethal dose (50 percent kill): 9500 mg/kg		GTPZAB 32(7),52,1988

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1840 µg/kg/4H/17W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other changes	GISAAA 39(12),26,1974
intraperitoneal/rat	lowest published toxic dose: 3 mL/kg/7D- intermittent	Reproductive: Maternal effects: Parturition Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	EVHPAZ 3,91,1973
oral/rat	lowest published toxic dose: 36 gm/kg/10D- continuous	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB89164826/AS
oral/rat	lowest published toxic dose: 2 gm/kg/10D- continuous	Behavioral: Fluid intake	NTIS** #PB89164826/AS
oral/rat	lowest published toxic dose: 8 gm/kg/10D- continuous	Behavioral: Food intake (animal)	NTIS** #PB89164826/AS
skin/human	lowest published toxic dose: 1290 mg/kg/30D- intermittent	Blood: Other changes	TPKVAL 15,49,1979
skin/rabbit	lowest published toxic dose: 360 gm/kg/90D- continuous	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli	HPV349 -,,2001
skin/rabbit	lowest published toxic dose: 360 mL/kg/13W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JPETAB 93,26,1948

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		EVHPAZ 3,73,1973
TOXICOLOGY REVIEW		RREVAH 54,1,1975
TOXICOLOGY REVIEW		EVHPAZ 4,3,1973
TOXICOLOGY REVIEW		JACTDZ 4(3),267,1985
TOXICOLOGY REVIEW		EMCPT* 2,137,2005
TOXICOLOGY REVIEW		ENTOX* -,422,2005
TOXICOLOGY REVIEW		IJTOFN 24,1,2005
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		REPTED 34,298,2012
TOXICOLOGY REVIEW		MUREAV 763,36,2014
TOXICOLOGY REVIEW		NRTXDN 41,112,2014
TOXICOLOGY REVIEW		RTOPDW 60,120,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 5 mg/m³	DTLVS* 3,91,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 3 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 3 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 3 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 5 mg/m³, MAC(short term exposure limit) 10 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 0.3 mg/m³, short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 3 mg/m³;short term exposure limit 5 mg/m³, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLPHTHALATE-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 59210; Number of Industries 56; Total Number of Facilities 6174; Number of Occupations 66; Total Number of Employees Exposed 57908; Total Number of Female Employees Exposed 16352
National Occupational Hazard Survey 1974	Hazard Code 59210; Number of Industries 38; Total Number of Facilities 2879; Number of Occupations 58; Total Number of Employees Exposed 50231

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #104

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health