Phenol, p-methoxy-
RTECS #
SL7700000
CAS #
Updated
June 2017
Molecular Weight
124.15
Molecular Formula
C7H8O2
Synonyms
4-Hydroxyanisole
4-Methoxyphenol
4-Methoxyphenol (ACGIH)
Hydroquinone monomethyl ether
Hydroxyanisole
Leucobasal
Leucodine B
Mechinolum
Mequinol
Mono methyl ether hydroquinone
Novo-Dermoquinona
P-Guaiacol
p-Hydroxyanisole
p-Hydroxymethoxybenzene
p-Methoxyphenol
PMF (antioxidant)
USAF AN-7
4-Methoxyphenol
4-Methoxyphenol (ACGIH)
Hydroquinone monomethyl ether
Hydroxyanisole
Leucobasal
Leucodine B
Mechinolum
Mequinol
Mono methyl ether hydroquinone
Novo-Dermoquinona
P-Guaiacol
p-Hydroxyanisole
p-Hydroxymethoxybenzene
p-Methoxyphenol
PMF (antioxidant)
USAF AN-7
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 6 gm/12D- intermittent | mild | JIHTAB 31,79,1949 |
skin /rabbit | 10% | VCVGK* -,299,1994 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | /hamster | 250 µmol/L | MUREAV 608,28,2006 |
Cytogenetic Analysis | ovary/hamster | 250 µmol/L | MUREAV 608,28,2006 |
DNA inhibition | lymphocyte/human | 25 µmol/L | RCOCB8 54,133,1986 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin/rat | 4440 mg/kg (6D preg-20D after birth) | Reproductive: Other effects on female Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Behavioral | HPV261 -,-,2003 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lethal dose (50 percent kill): 250 mg/kg | NTIS** AD691-490 | |
intraperitoneal/mouse | lowest published toxic dose: 200 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | CBINA8 142,317,2003 |
oral/rat | lethal dose (50 percent kill): 1600 mg/kg | VCVGK* -,299,1994 | |
Tank with water/Zebrafish | lowest published toxic concentration: 2 mg/L/48H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other | JOETD7 154,240,2014 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/Dog | lowest published toxic dose: 33.6 gm/kg/4W- intermittent | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV082 -,-,2002 |
oral/mouse | lowest published toxic dose: 7508 ng/kg/12D- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BJCAAI 45,935,1982 |
oral/rabbit | lowest published toxic dose: 105 gm/kg/5W- intermittent | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV082 -,-,2002 |
oral/rat | lowest published toxic dose: 0.735 mg/kg/7W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,299,1994 |
oral/rat | lowest published toxic dose: 18375 mg/kg/7W- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Endocrine: Differential effect of sex or castration on observed toxicity Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV082 -,-,2002 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 mg/m3 | DTLVS* TLV/BEI,2013 |
TOXICOLOGY REVIEW | JACTDZ 4(5),31,1985 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 672,10,2009 | |
TOXICOLOGY REVIEW | MUREAV 672,17,2009 | |
TOXICOLOGY REVIEW | MUREAV 750,1,2012 | |
TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
TOXICOLOGY REVIEW | MUREAV 802,1,2016 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-METHOXYPHENOL-air | 10H time-weighted average 5 mg/m3 | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code X3672; Number of Industries 136; Total Number of Facilities 9805; Number of Occupations 89; Total Number of Employees Exposed 250087; Total Number of Female Employees Exposed 49763 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health