2-Pentanone

RTECS #

SA7875000

CAS #

107-87-9
See: NMAM or OSHA Methods

Updated

October 2014

Molecular Weight

86.15

Molecular Formula

C₅H₁₀O

Synonyms

2-Pentanone (OSHA)
Ethyl acetone
Methyl propyl ketone
Methyl propyl ketone (ACGIH:OSHA)
Methyl-n-propyl ketone
Methylpropyl ketone
Methyl-propyl-cetone (French)
Metylopropyloketon (Polish)
MPK

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	405 mg open irritation test	mild	UCDS** 7/20/1967

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	13600 ppm	MUREAV 149,339,1985

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	lowest published toxic concentration: 50000 mg/m³	Gastrointestinal: Changes in structure or function of salivary glands	VCVGK* -,421,1994
inhalation/guinea pig	Lowest published lethal concentration: 105000 mg/m³/30M	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,421,1994
inhalation/guinea pig	Lowest published lethal concentration: 13000 ppm/5H		85INA8 6,1036,1991
inhalation/human	lowest published toxic concentration: 1500 ppm	Eye: Other eye effects Behavioral: Headache Gastrointestinal: Nausea or vomiting	NPIRI* 1,83,1974
inhalation/human	lowest published toxic concentration: 3000 mg/m³	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,421,1994
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 22 gm/m³		GISAAA 51(5),61,1986
inhalation/mouse	lowest published toxic concentration: 15000 mg/m³/2H	Behavioral: Alteration of classical conditioning	VCVGK* -,421,1994
inhalation/mouse	lethal concentration (50 percent kill): 22000 mg/m³/2H		VCVGK* -,421,1994
inhalation/rabbit	lowest published toxic concentration: 1250 mg/m³	Brain and Coverings: Other degenerative changes	VCVGK* -,421,1994
inhalation/rat	Lowest published lethal concentration: 2000 ppm/4H		HPV057 -,-,2001
intraperitoneal/mouse	lethal dose (50 percent kill): 1600 mg/kg		38MKAJ 2C,4735,1982
intraperitoneal/rat	lethal dose (50 percent kill): 800 mg/kg		38MKAJ 2C,4735,1982
oral/mammal (species unspecified)	lethal dose (50 percent kill): 3700 mg/kg		GTPZAB 32(10),25,1988
oral/mouse	lethal dose (50 percent kill): 1600 mg/kg		38MKAJ 2C,4735,1982
oral/mouse	lowest published lethal dose: 1600 mg/kg		HPV057 -,-,2001
oral/rat	lowest published lethal dose: 3200 mg/kg		HPV057 -,-,2001
oral/rat	lethal dose (50 percent kill): 1600 mg/kg		38MKAJ 2C,4735,1982
skin/rabbit	lethal dose (50 percent kill): 6500 mg/kg		NPIRI* 1,83,1974

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1074 mg/kg/4D- intermittent	Liver: Other changes	HPV057 -,-,2001
inhalation/rat	lowest published toxic concentration: 5000 mg/m³/35D- intermittent	Behavioral: Somnolence (general depressed activity)	HPV057 -,-,2001
oral/rat	lowest published toxic dose: 177060 mg/kg/52W- intermittent	Kidney, Ureter, and Bladder: Other changes Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV057 -,-,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-short term exposure limit 150 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 199,203,2010

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 200 ppm (700 mg/m³)	DTLVS* 3,200,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 200 ppm (705 mg/m³), short term exposure limit 250 ppm (881 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 200 ppm (700 mg/m³);KZW 400 ppm (1400 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 200 ppm(715 mg/m³), short term exposure limit 250 ppm(894 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 200 ppm (700 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 200 ppm (710 mg/m³), short term exposure limit 250 ppm (890 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 200 ppm (705 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 200 ppm (700 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 200 ppm (700 mg/m³), short term exposure limit 250 ppm (875 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 200 ppm (700 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 200 ppm (705 mg/m³); short term exposure limit 250 ppm (881 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 200 ppm (705 mg/m³); short term exposure limit 250 ppm (881 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 100 mg/m³, MAC(short term exposure limit) 800 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 200 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 200 ppm (700 mg/m³), KZG-week 400 ppm (1400 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 700 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 200 ppm (700 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 200 ppm (700 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 200 ppm (716 mg/m³);short term exposure limit 250 ppm (895 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 200 ppm (700 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 200 ppm (700 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 200 ppm (700 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 200 ppm (700 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL PROPYL KETONE-air	10H time-weighted average 150 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 54480; Number of Industries 17; Total Number of Facilities 930; Number of Occupations 13; Total Number of Employees Exposed 8218; Total Number of Female Employees Exposed 1129
National Occupational Hazard Survey 1974	Hazard Code 54480; Number of Industries 4; Total Number of Facilities 39; Number of Occupations 11; Total Number of Employees Exposed 789

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health