2-Naphthylamine, N-phenyl-

RTECS #

QM4550000

CAS #

135-88-6
See: NMAM or OSHA Methods

Updated

June 2018

Molecular Weight

219.30

Molecular Formula

C₁₆H₁₃N

Synonyms

2-Anilinonaphthalene
2-Naphthylphenylamine
2-Phenylaminonaphthalene
Aceto PBN
AgeRite Powder
AK 1
AK 1 (stabilizer)
Antioxidant 116
Antioxidant D
Antioxidant PBN
beta-Naphthylphenylamine
Fenyl-beta-naftylamin (Czech)
N-(2-Naphthyl)aniline
Naftam 2
NCI-C02915
Neozon D
Neozone
Neozone D
N-Fenyl-2-aminonaftalen (Czech)
Nilox PbNa
Noclizer D
Nocrac D
Nonox D
N-Phenyl-2-naphthylamine
N-Phenyl-beta-naphthylamine
N-Phenyl-beta-naphthylamine (ACGIH)
PBNA
Phenyl-2-naphthylamine
Phenyl-beta-naphthylamine
Stabilizator AR
Stabilizer AR
Vulkanox PBN

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/mouse	360 mg/kg/18D	GTPZAB 23(9),57,1979
morphological transform	other cell types/human	23100 µg/L	ITCSAF 17,719,1981
mutation in microorganisms	/Salmonella typhimurium	50 pph (+enzymatic activation step)	CYGEDX 21(6),29,1987
specific locus test	inhalation/mouse	59.3 µmol/L	MUREAV 608,29,2006

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	18200 mg/kg (26W male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TPKVAL 12,86,1971

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	toxic dose: 264 gm/kg/99W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	SYSWAE 14,129,1981
oral/mouse	toxic dose: 135 gm/kg/78W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors	NTIS** PB223-159
oral/mouse	toxic dose: 17280 mg/kg/9W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Kidney, Ureter, and Bladder: Kidney tumors	CNREA8 44,3098,1984
oral/mouse	lowest published toxic dose: 648900 mg/kg/103W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Kidney, Ureter, and Bladder: Kidney tumors	NTIS** PB88-216270/AS
oral/mouse	lowest published toxic dose: 433 gm/kg/2Y- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	NTPTR* NTP-TR-333,1988
oral/mouse	lowest published toxic dose: 208 gm/kg/97W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Liver: Tumors	SYSWAE 14,129,1981
subcutaneous/mouse	lowest published toxic dose: 464 mg/kg	Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors	NTIS** PB223-159

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	Lowest published lethal concentration: 0.9 gm/m³/2H	Brain and Coverings: Changes in circulation Brain and Coverings: Other degenerative changes Behavioral: Coma	TPKVAL 6,37,1964
oral/mouse	lethal dose (50 percent kill): 1450 mg/kg	Behavioral: Somnolence (general depressed activity)	HYSAAV 31(1-3),183,1966
oral/rat	lowest published toxic dose: 8000 mg/kg		TPKVAL 12,86,1971
oral/rat	lethal dose (50 percent kill): 8730 mg/kg	Behavioral: Somnolence (general depressed activity)	HYSAAV 31(1-3),183,1966
subcutaneous/mouse	lowest published toxic dose: 1000 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: General anesthetic	TPKVAL 6,37,1964
subcutaneous/rat	lowest published toxic dose: 1000 mg/kg	Lung, Thorax, or Respiration: Respiratory obstruction Liver: Fatty liver degeneration Biochemical: Metabolism (intermediary): Other	TPKVAL 6,37,1964
unreported route/rat	lethal dose (50 percent kill): 8700 mg/kg	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes	TJSGA8 53,415,1975

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 100 gm/m³/6D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 10,90,1968
inhalation/guinea pig	lowest published toxic concentration: 100 gm/m³/12D- intermittent	Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 6,37,1964
inhalation/rat	lowest published toxic concentration: 0.9 gm/m³/10D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen	TPKVAL 6,37,1964
oral/guinea pig	lowest published toxic dose: 6000 mg/kg/40D- intermittent	Vascular: Other changes Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TPKVAL 6,37,1964
oral/mouse	lowest published toxic dose: 437 gm/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-333,1988
oral/rabbit	lowest published toxic dose: 5000 mg/kg/5D- intermittent	Kidney, Ureter, and Bladder: Proteinuria Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 6,37,1964
oral/rabbit	lowest published toxic dose: 12000 mg/kg/3D- intermittent	Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 6,37,1964
oral/rat	lowest published toxic dose: 52 gm/kg/30D- intermittent	Liver: Liver function tests impaired Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GISAAA 31(2),25,1966
oral/rat	lowest published toxic dose: 182 gm/kg/13W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-333,1988
oral/rat	lowest published toxic dose: 19 gm/kg/19D- intermittent	Kidney, Ureter, and Bladder: Proteinuria Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 36400 mg/kg/1Y- intermittent	Liver: Liver function tests impaired Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Proteinuria	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 4000 mg/kg/4D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 3650 mg/kg/0.5Y- continuous	Gastrointestinal: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes in urine composition	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 54700 mg/kg/1.5Y- continuous	Kidney, Ureter, and Bladder: Urine volume decreased or anuria	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 3000 mg/kg/30D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Proteinuria	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 36500 mg/kg/1Y- continuous	Lung, Thorax, or Respiration: Changes in lung weight	TPKVAL 12,86,1971
oral/rat	lowest published toxic dose: 18200 mg/kg/0.5Y- continuous	Gastrointestinal: Necrotic changes Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TPKVAL 12,86,1971
subcutaneous/rat	lowest published toxic dose: 30000 mg/kg/60W- intermittent	Skin and Appendages: Tumors Tumorigenic: Protects against induction of experimental tumors	VOONC* 37,60,1991

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Control as low as possible	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 16,325,1978
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 16,325,1978
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMSUDL 7,318,1987
TOXICOLOGY REVIEW		TOLED5 134,39,2002
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUTAEX 32,491,2017

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	Carcinogen, JUL2008
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0.03 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	Group B Carcinogen, JUN2005

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-PHENYL-beta-NAPHTHYLAMINE-air	Carcinogen lowest concentration	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 80313; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 4; Total Number of Employees Exposed 1356; Total Number of Female Employees Exposed 41
National Occupational Hazard Survey 1974	Hazard Code 80313; Number of Industries 15; Total Number of Facilities 751; Number of Occupations 32; Total Number of Employees Exposed 16148

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat
NIOSH CURRENT INTELLIGENCE BULLETIN 16, 1976
OSHA ANALYTICAL METHOD #96

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health