Methane, tribromo-
RTECS #
PB5600000
CAS #
Updated
December 2018
Molecular Weight
252.75
Molecular Formula
CHBr3
Synonyms
Bromoform
Bromoform (ACGIH:OSHA)
Bromoforme (French)
Bromoformio (Italian)
Methenyl tribromide
Methyl tribromide
NCI-C55130
RCRA waste number U225
Tribrommethaan (Dutch)
Tribrommethan (German)
Tribromometan (Italian)
Tribromomethane
Bromoform (ACGIH:OSHA)
Bromoforme (French)
Bromoformio (Italian)
Methenyl tribromide
Methyl tribromide
NCI-C55130
RCRA waste number U225
Tribrommethaan (Dutch)
Tribrommethan (German)
Tribromometan (Italian)
Tribromomethane
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | intraperitoneal/rat | 25300 µg/kg | MUREAV 242,111,1990 |
Cytogenetic Analysis | oral/rat | 1265 mg/kg/5D- intermittent | MUREAV 242,111,1990 |
Cytogenetic Analysis | ovary/hamster | 110 µg/L | ENMUDM 7,1,1985 |
DNA Damage | lung/human | 100 µmol/L/3H | MUREAV 538,41,2003 |
DNA Damage | other cell types/human | 1 mmol/L/4H | MUREAV 741,89,2012 |
micronucleus test | intratracheal/mouse | 800 mg/kg/48H- intermittent | NTPTR* NTP-TR-350,1989 |
micronucleus test | multiple/non-mammalian species | 5 ppm | MUREAV 292,83,1993 |
morphological transform | fibroblast/mouse | 0.05 mg/L/21D (-enzymatic activation step) | EMMUEG 37,231,2001 |
mutation in mammalian somatic cells | lymphocyte/mouse | 200 mg/L | NTPTR* NTP-TR-350,1989 |
mutation in microorganisms | /Salmonella typhimurium | 1000 mg/L/2H (-enzymatic activation step) | EMMUEG 44,329,2004 |
mutation in microorganisms | /Salmonella typhimurium | 666 µg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (-enzymatic activation step) | NTPTR* NTP-TR-350,1989 |
sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 3000 ppm | ENMUDM 7,677,1985 |
sister chromatid exchange | ovary/hamster | 290 µg/L | ENMUDM 7,1,1985 |
sister chromatid exchange | lymphocyte/human | 80 µmol/L | ENVRAL 32,72,1983 |
sister chromatid exchange | oral/mouse | 100 mg/kg/4D- intermittent | ENVRAL 32,72,1983 |
sister chromatid exchange | intratracheal/mouse | 800 gm/L | NTPTR* NTP-TR-350,1989 |
sister chromatid exchange | leukocyte/rat | 20 µmol/L | MUREAV 300,241,1993 |
specific locus test | oral/Drosophila melanogaster | 3000 ppm | NTPTR* NTP-TR-350,1989 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | 5.6 gm/kg (7D prior to copulation/21D pregnant) | Reproductive: Maternal effects: Postpartum | NTIS** #PB89169254 |
oral/mouse | 47 gm/kg (15W male/15W pre-4D after birth) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB89169254 |
oral/mouse | 200 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system | NTIS** #PB89169254 |
oral/mouse | 200 mg/kg (multigenerations) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB89169254 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/mouse | lowest published toxic dose: 1100 mg/kg/8W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | CNREA8 37,2717,1977 |
oral/rat | lowest published toxic dose: 103000 mg/kg/103W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NTIS** PB90-110149/AS |
oral/rat | lowest published toxic dose: 103000 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTIS** PB90-110149/AS |
oral/rat | lowest published toxic dose: 10400 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTPTR* NTP-TR-350,1989 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/mammal (species unspecified) | lethal concentration (50 percent kill): 12100 mg/m3 | GTPZAB 18(4),55,1974 | |
inhalation/mouse | lethal concentration (50 percent kill): 12100 mg/m3/2H | Lung, Thorax, or Respiration: Other changes | VCVGH* -,581,1990 |
inhalation/rat | lowest published toxic concentration: 3900 mg/m3/2H | Brain and Coverings: Changes in surface EEG | VCVGH* -,581,1990 |
inhalation/rat | Lowest published lethal concentration: 45 gm/m3/4H | 85GMAT -,28,1982 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 1274 mg/kg | VCVGH* -,572,1990 | |
intraperitoneal/rat | lethal dose (50 percent kill): 414 mg/kg | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Behavioral: Antipsychotic | TOLED5 15,251,1983 |
oral/human | lowest published lethal dose: 143 mg/kg | 34ZIAG -,141,1969 | |
oral/mouse | lethal dose (50 percent kill): 1072 mg/kg | Lung, Thorax, or Respiration: Dyspnea | NTPTR* NTP-TR-350,1989 |
oral/rat | lethal dose (50 percent kill): 933 mg/kg | Lung, Thorax, or Respiration: Dyspnea | NTPTR* NTP-TR-350,1989 |
subcutaneous/mouse | lethal dose (50 percent kill): 1820 mg/kg | TXAPA9 4,354,1962 | |
subcutaneous/rabbit | lowest published lethal dose: 410 mg/kg | AEXPBL 28,201,1891 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/mouse | lowest published toxic dose: 3500 mg/kg/14D- intermittent | Liver: Changes in liver weight Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | EVHPAZ 46,117,1982 |
oral/mouse | lowest published toxic dose: 6500 mg/kg/13W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-350,1989 |
oral/mouse | lowest published toxic dose: 296 mg/kg/14D- intermittent | Kidney, Ureter, and Bladder: Changes primarily in glomeruli Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGH* -,581,1990 |
oral/mouse | lowest published toxic dose: 21000 mg/kg/15W- intermittent | Behavioral: Fluid intake | NTIS** #PB89169254 |
oral/rat | lowest published toxic dose: 6230 mg/kg/4W- continuous | Liver: Other changes Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | JTSCDR 17,119,1992 |
oral/rat | lowest published toxic dose: 13 gm/kg/13W- intermittent | Liver: Other changes | NTPTR* NTP-TR-350,1989 |
oral/rat | lowest published toxic dose: 5600 mg/kg/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-350,1989 |
oral/rat | lowest published toxic dose: 5840 mg/kg/1Y- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition | TOXID9 14,281,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 52,213,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Limited Evidence | IMEMDT 71,1309,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 52,213,1991 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1309,1999 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 71,1309,1999 |
TOXICOLOGY REVIEW | MUREAV 564,179,2004 | |
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | TXCYAC 198,239,2004 | |
TOXICOLOGY REVIEW | ENTOX* -,345,2005 | |
TOXICOLOGY REVIEW | ENTOX* -,546,2005 | |
TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
TOXICOLOGY REVIEW | MUREAV 636,242,2007 | |
TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
TOXICOLOGY REVIEW | MUREAV 608,157,2006 | |
TOXICOLOGY REVIEW | TXAPA9 254,100,2011 | |
TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
TOXICOLOGY REVIEW | MUREAV 831,1,2018 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 ppm (5 mg/m3) (skin) | DTLVS* 3,28,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 ppm (5.2 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 ppm (5 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 ppm (5.3 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.5 ppm (5 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (5.2 mg/m3), short term exposure limit 1.5 ppm (16 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.5 ppm (5 mg/m3), Skin, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.5 ppm (5 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 1 ppm (10.3 mg/m3), MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.5 ppm (5 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.5 ppm (5 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 ppm (5.2 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 0,5 ppm (5,2 mg/m3), JUL2005 | |
Occupational Exposure Limit-POLAND | time-weighted average 5 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | short term exposure limit 5 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 ppm (5 mg/m3), carc 3, skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 5 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 ppm (5 mg/m3), Skin, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 ppm (5 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 ppm (5 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 ppm (5 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 ppm (5 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMOFORM-air | 10H time-weighted average 0.5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 13160; Number of Industries 1; Total Number of Facilities 14; Number of Occupations 2; Total Number of Employees Exposed 1473; Total Number of Female Employees Exposed 230 | |
National Occupational Hazard Survey 1974 | Hazard Code 13160; Number of Industries 3; Total Number of Facilities 43; Number of Occupations 3; Total Number of Employees Exposed 242 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health