Methane, iodo-

RTECS #

PA9450000

CAS #

74-88-4
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

141.94

Molecular Formula

CH₃I

Synonyms

Halon 10001
Iodometano (Italian)
Iodomethane
Iodure de methyle (French)
Jod-methan (German)
Joodmethaan (Dutch)
Methyl iodide
Methyl iodide (ACGIH:OSHA)
Methyljodid (German)
Methyljodide (Dutch)
Metylu jodek (Polish)
Monoioduro di metile (Italian)
RCRA waste number U138

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	severe	NTIS** OTS0570629
skin /human	1 gm/10M	mild	BJIMAG 7,122,1950
skin /rabbit	500 mg	severe	NTIS** OTS0570629
skin /rat	1 gm/30M	mild	BJIMAG 7,122,1950

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA Damage	/Escherichia coli	1 µmol/L	ARTODN 46,277,1980
DNA repair	/Escherichia coli	10 µg/disc	JJIND8 62,873,1979
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	1000 ppm	JJIND8 62,901,1979
morphological transform	embryo/hamster	1 mg/L	IJCNAW 19,642,1977
mutation in mammalian somatic cells	ovary/hamster	2 mg/L	MUREAV 136,137,1984
mutation in mammalian somatic cells	lymphocyte/mouse	3600 µg/L	ENMUDM 7,523,1985
mutation in microorganisms	lymphocyte/mouse	50 mg/L/4H (+enzymatic activation step)	MUREAV 59,61,1979
mutation in microorganisms	/Salmonella typhimurium	2 µL/plate (+/-enzymatic activation step)	JJIND8 62,873,1979
mutation in microorganisms	/Escherichia coli	20 µmol/L (-enzymatic activation step)	ARTODN 46,277,1980

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	20 ppm (6-28D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TOXID9 44,50,2005

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lowest published toxic dose: 44 mg/kg/8W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors	CNREA8 35,1411,1975
subcutaneous/rat	lowest published toxic dose: 50 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Colon tumors Tumorigenic: Tumors at site of application	ZEKBAI 74,241,1970

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 5 gm/m³/57M-continuous		BJIMAG 7,122,1950
inhalation/mouse	lethal concentration (50 percent kill): 5000 mg/m³/57M		VCVGH* -,603,1990
inhalation/rat	lethal concentration (50 percent kill): 1300 mg/m³/4H		VCVGH* -,603,1990
inhalation/rat	lowest published toxic concentration: 200 ppm/2H	Olfaction: Ulcerated nasal septum Olfaction: Other olfaction effects	TOXID9 60,150,2001
intraperitoneal/guinea pig	lethal dose (50 percent kill): 51 mg/kg		85GMAT -,84,1982
intraperitoneal/mouse	lethal dose (50 percent kill): 172 mg/kg		85GMAT -,84,1982
intraperitoneal/rat	lethal dose (50 percent kill): 101 mg/kg		85GMAT -,84,1982
oral/rabbit	lowest published lethal dose: 70 mg/kg		38MKAJ 2B,3447,1981
oral/rat	lethal dose (50 percent kill): 76 mg/kg		BIJOAK 98,38,1966
skin/guinea pig	lethal dose (50 percent kill): 800 mg/kg		KODAK* 21MAY1971
skin/rabbit	lowest published lethal dose: 794 mg/kg	Lung, Thorax, or Respiration: Other changes Gastrointestinal: Other changes Blood: Hemorrhage	NTIS** OTS0570629
subcutaneous/mouse	lethal dose (50 percent kill): 110 mg/kg		TXAPA9 4,354,1962
subcutaneous/rat	lethal dose (50 percent kill): 110 mg/kg		ZEKBAI 74,241,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 100 mg/m³/5H/16W- intermittent	Blood: Changes in other cell count (unspecified) Musculoskeletal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGH* -,604,1990
inhalation/rat	lowest published toxic concentration: 25 ppm/6H/2D- intermittent	Liver: Other changes Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 44,49,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm (skin)	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 41,213,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 71,1503,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 41,213,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,1503,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 71,1503,1999
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 763,294,2015
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		RTOPDW 54,247,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 5 ppm (28 mg/m³) (skin)	DTLVS* 3,166,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (12 mg/m³), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIA	TRK-TMW 0.3 ppm (2 mg/m³);KZW 1.2 ppm (8 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (12 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (5.6 mg/m³), skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 2 ppm (12 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (12 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (6 mg/m³), carc, skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 2 ppm (10 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 2 ppm (10 mg/m³);short term exposure limit 5 ppm (30 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 2 ppm (12 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (5 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (11,6 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 10 mg/m³, MAC(short term exposure limit) 30 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	time-weighted average 1 ppm (6 mg/m³);short term exposure limit 5 ppm (30 mg/m³), Skin, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.3 ppm (2 mg/m³), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 2 ppm (12 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 ppm (28 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 ppm (28 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 ppm (28 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 ppm (28 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL IODIDE-air	10H Carcinogen time-weighted average 2 ppm (Sk) (1.7 ppm LOQ)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M0422; Number of Industries 2; Total Number of Facilities 34; Number of Occupations 6; Total Number of Employees Exposed 2182; Total Number of Female Employees Exposed 440
National Occupational Hazard Survey 1974	Hazard Code M0422; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 4; Total Number of Employees Exposed 413

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl iodide, 1014
NIOSH CURRENT INTELLIGENCE BULLETIN 43, 1984
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health