2-Hexanone
RTECS #
MP1400000
CAS #
Updated
September 2013
Molecular Weight
100.18
Molecular Formula
C6H12O
Synonyms
2-Hexanone (OSHA)
Butyl methyl ketone
Hexanone-2
Ketone, butyl methyl
MBK
Methyl n-butyl ketone
Methyl n-butyl ketone (ACGIH:OSHA)
MNBK
n-Butyl methyl ketone
Propylacetone
Butyl methyl ketone
Hexanone-2
Ketone, butyl methyl
MBK
Methyl n-butyl ketone
Methyl n-butyl ketone (ACGIH:OSHA)
MNBK
n-Butyl methyl ketone
Propylacetone
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,283,1986 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,283,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 48 mmol/L | MUREAV 341,83,1994 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 1000 ppm/6H (1-21D pregnant) | Reproductive: Specific developmental abnormalities: Gastrointestinal system Reproductive: Specific developmental abnormalities: Urogenital system | EESADV 5,291,1981 |
| inhalation/rat | 2000 ppm/6H (1-21D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | EESADV 5,291,1981 |
| inhalation/rat | 2045 mg/m3 (1-22D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | VCVGK* -,424,1994 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | Lowest published lethal concentration: 40000 mg/m3/30M | Brain and Coverings: Increased intracranial pressure Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,423,1994 |
| inhalation/human | lowest published toxic concentration: 4000 mg/m3 | Olfaction: Other olfaction effects Eye: Conjunctiva irritation | VCVGK* -,423,1994 |
| inhalation/human | lowest published toxic concentration: 1000 ppm | Eye: Other eye effects Behavioral: Headache Gastrointestinal: Nausea or vomiting | NPIRI* 1,78,1974 |
| inhalation/rat | lethal concentration (50 percent kill): 8000 ppm/4H | NPIRI* 1,78,1974 | |
| intraperitoneal/rat | lowest published lethal dose: 914 mg/kg | RalRL# 01MAR1974 | |
| oral/guinea pig | lowest published lethal dose: 914 mg/kg | RalRL# 01MAR1974 | |
| oral/human | lowest published lethal dose: 714.3 mg/kg | VCVGK* -,423,1994 | |
| oral/mouse | lethal dose (50 percent kill): 2430 mg/kg | TOLED5 30,13,1986 | |
| oral/rat | lethal dose (50 percent kill): 2590 mg/kg | AMIHBC 10,61,1954 | |
| oral/rat | lowest published toxic dose: 1503 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | VCVGK* -,423,1994 |
| skin/rabbit | lethal dose (50 percent kill): 4800 mg/kg | NPIRI* 1,78,1974 | |
| unreported route/guinea pig | lethal dose (50 percent kill): 914 mg/kg | RalRL# 01MAR1974 | |
| unreported route/rat | lethal dose (50 percent kill): 914 mg/kg | RalRL# 01MAR1974 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | lowest published toxic concentration: 400 ppm/24H/33D- continuous | Peripheral Nerve and Sensation: Structural change in nerve or sheath | NEJMAG 290,1263,1974 |
| inhalation/cat | lowest published toxic concentration: 818 mg/m3/5W- continuous | Peripheral Nerve and Sensation: Structural change in nerve or sheath | VCVGK* -,424,1994 |
| inhalation/chicken | lowest published toxic concentration: 818 mg/m3/4W- continuous | Peripheral Nerve and Sensation: Structural change in nerve or sheath | VCVGK* -,424,1994 |
| inhalation/chicken | lowest published toxic concentration: 200 ppm/90D- continuous | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTEHD6 9,199,1982 |
| inhalation/monkey | lowest published toxic concentration: 409 mg/m3/6H/13W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | VCVGK* -,424,1994 |
| inhalation/monkey | lowest published toxic concentration: 976 ppm/6H/25W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | AIHAAP 38,567,1977 |
| inhalation/rat | lowest published toxic concentration: 692 ppm/81D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Muscle weakness Related to Chronic Data: Changes in testicular weight | TXAPA9 52,153,1980 |
| inhalation/rat | lowest published toxic concentration: 976 ppm/6H/25W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Behavioral: Alteration of operant conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AIHAAP 38,567,1977 |
| inhalation/rat | lowest published toxic concentration: 1300 ppm/6H/17W- intermittent | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | ARNEAS 32,219,1975 |
| inhalation/rat | lowest published toxic concentration: 400 ppm/24H/42D- continuous | Peripheral Nerve and Sensation: Structural change in nerve or sheath | JNENAD 35,207,1976 |
| inhalation/rat | lowest published toxic concentration: 4090 mg/m3/6H/13W- intermittent | Behavioral: Alteration of operant conditioning | VCVGK* -,424,1994 |
| inhalation/rat | lowest published toxic concentration: 818 mg/m3/11W- continuous | Peripheral Nerve and Sensation: Structural change in nerve or sheath | VCVGK* -,424,1994 |
| inhalation/rat | lowest published toxic concentration: 2863 mg/m3/72H- intermittent | Behavioral: Muscle weakness | VCVGK* -,423,1994 |
| inhalation/rat | lowest published toxic concentration: 2863 mg/m3/72H- intermittent | Behavioral: Muscle weakness Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,423,1994 |
| inhalation/rat | lowest published toxic concentration: 4007000 mg/m3/5W- continuous | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | VCVGK* -,423,1994 |
| inhalation/rat | lowest published toxic concentration: 2045 mg/m3/22D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,424,1994 |
| inhalation/rat | lowest published toxic concentration: 409 mg/m3/6H/13W- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve | VCVGK* -,424,1994 |
| inhalation/rat | lowest published toxic concentration: 818 mg/m3/8H/6W- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Muscle weakness | VCVGK* -,424,1994 |
| intraperitoneal/chicken | lowest published toxic dose: 3000 mg/kg/30D- intermittent | Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Ataxia | VCVGK* -,424,1994 |
| oral/guinea pig | lowest published toxic dose: 59262 mg/kg/24W- continuous | Eye: Miosis (pupilliary constriction) Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Other changes | AIHAAP 39,94,1978 |
| oral/guinea pig | lowest published toxic dose: 9520 mg/kg/8W- continuous | Eye: Miosis (pupilliary constriction) Behavioral: Somnolence (general depressed activity) | VCVGK* -,424,1994 |
| oral/rat | lowest published toxic dose: 59.506 gm/kg/90D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,424,1994 |
| subcutaneous/cat | lowest published toxic dose: 55500 mg/kg/37W- intermittent | Brain and Coverings: Demyelination Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | TXAPA9 37,301,1976 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 10 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ARPTDI 22,145,1982 | |
| TOXICOLOGY REVIEW | HUTOX* -,577,1996 | |
| TOXICOLOGY REVIEW | HUTOX* -,649,1996 | |
| TOXICOLOGY REVIEW | NTAPM* -,629,1995 | |
| TOXICOLOGY REVIEW | NTAPM* -,689,1995 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (410 mg/m3) | DTLVS* 3,126,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (20 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (21 mg/m3);KZW 20 ppm (84 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (20 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (4 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (20 mg/m3), VLE 8 ppm (35 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 5 ppm (21 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 21 mg/m3, short term exposure limit 84 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 ppm (4 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 ppm (20 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (20 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (20 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (20 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (4 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (20 mg/m3); short term exposure limit 10 ppm (41 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 10 mg/m3, MAC(short term exposure limit) 50 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 5 ppm, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (4 mg/m3);short term exposure limit 2 ppm (8 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (21 mg/m3), KZG-week 40 ppm (168 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 2 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (410 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (410 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (21 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (410 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (410 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (410 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (410 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL BUTYL KETONE-air | 10H time-weighted average 1 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 37330; Number of Industries 5; Total Number of Facilities 168; Number of Occupations 5; Total Number of Employees Exposed 1122; Total Number of Female Employees Exposed 656 | |
| National Occupational Hazard Survey 1974 | Hazard Code 37330; Number of Industries 76; Total Number of Facilities 5073; Number of Occupations 45; Total Number of Employees Exposed 41624 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health