Ethanol, 2-ethoxy-
RTECS #
KK8050000
CAS #
Updated
March 2019
Molecular Weight
90.14
Molecular Formula
C4H10O2
Synonyms
2-Ethoxyethanol
2-Ethoxyethanol (ACGIH:OSHA)
Athylenglykol-monoathylather (German)
Cellosolve
Cellosolve (OSHA)
Cellosolve solvent
Celosolv (Czech)
Dowanol 8
Dowanol EE
EGEE
Ektasolve EE
Ether monoethylique de l'ethylene-glycol (French)
Ethyl cellosolve
Ethylene glycol ethyl ether
Ethylene glycol monoethyl ether
Etoksyetylowy alkohol (Polish)
Glycol monoethyl ether (OSHA)
Jeffersol EE
NCI-C54853
Oxitol
Poly-Solv EE
RCRA waste number U227
RCRA waste number U359
2-Ethoxyethanol (ACGIH:OSHA)
Athylenglykol-monoathylather (German)
Cellosolve
Cellosolve (OSHA)
Cellosolve solvent
Celosolv (Czech)
Dowanol 8
Dowanol EE
EGEE
Ektasolve EE
Ether monoethylique de l'ethylene-glycol (French)
Ethyl cellosolve
Ethylene glycol ethyl ether
Ethylene glycol monoethyl ether
Etoksyetylowy alkohol (Polish)
Glycol monoethyl ether (OSHA)
Jeffersol EE
NCI-C54853
Oxitol
Poly-Solv EE
RCRA waste number U227
RCRA waste number U359
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /guinea pig | 10 µg | mild | JPPMAB 11,150,1959 |
| eye /human | 6000 ppm | PHRPA6 45,1459,1930 | |
| eye /rabbit | 50 mg | moderate | UCDS** 5/20/1966 |
| eye /rabbit | 500 mg/24H | mild | 85JCAE -,624,1986 |
| skin /rabbit | 500 mg open irritation test | mild | UCDS** 5/20/1966 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | ovary/hamster | 6830 mg/L | EMMUEG 10(Suppl 10),1,1987 |
| sister chromatid exchange | ovary/hamster | 3170 mg/L | EMMUEG 10(Suppl 10),1,1987 |
| sperm morphology | oral/rat | 23400 mg/kg/5W- intermittent | TXAPA9 84,576,1986 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 10 ppm/6H (6-15D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Musculoskeletal system | EVHPAZ 57,33,1984 |
| inhalation/rat | 200 ppm/7H (1-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | SWEHDO 7(Suppl 4),66,1981 |
| inhalation/rat | 600 ppm/7H (7-13D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death | NRTXDN 2,231,1981 |
| inhalation/rat | 100 ppm/7H (14-20D pregnant) | Reproductive: Maternal effects: Parturition Reproductive: Effects on newborn: Behavioral | TJADAB 21,58A,1980 |
| inhalation/rabbit | 400 ppm/6H (65D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | EVHPAZ 57,157,1984 |
| inhalation/rabbit | 160 ppm/7H (1-18D pregnant) | Reproductive: Specific developmental abnormalities: Body wall Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | SWEHDO 7(Suppl 4),66,1981 |
| inhalation/rabbit | 175 ppm/6H (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | NTIS** OTS0571396 |
| inhalation/rabbit | 160 ppm/7H (1-18D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | SWEHDO 7(Suppl 4),66,1981 |
| inhalation/rabbit | 617 ppm/7H (1-18D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Other measures of fertility | NTIS** PB83-208074 |
| inhalation/rabbit | 400 ppm/6H (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | NTIS** OTS0546094 |
| inhalation/rat | 2270 mg/m3/7H (1-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | VCVGK* -,163,1994 |
| oral/mouse | 220.5 gm/kg (21W male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | NTIS** #PB85118651 |
| oral/mouse | 220.5 gm/kg (21W prior to copulation) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85118651 |
| oral/mouse | 382.2 gm/kg (21W prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | NTIS** #PB85118651 |
| oral/mouse | 52.5 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB85118651 |
| oral/rat | 1500 mg/kg (3D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TOLED5 190,193,2009 |
| oral/rat | 17500 mg/kg (35D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | REPTED 14,55,2000 |
| oral/mouse | 28840 mg/kg (7-14D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | EVHPAZ 57,141,1984 |
| oral/rat | 500 mg/kg (5D male) | Reproductive: Effects on fertility: Other measures of fertility | FAATDF 5,182,1985 |
| oral/rat | 7820 mg/kg (1-21D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Abortion | ARZNAD 21,880,1971 |
| oral/rat | 600 mg/kg (10-12D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | TOXID9 4,87,1984 |
| oral/rat | 1800 mg/kg (7-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | TOXID9 4,87,1984 |
| oral/rat | 4500 mg/kg (6W male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | FAATDF 7,348,1986 |
| oral/mouse | 25 gm/kg (25D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | SAIGBL 21,29,1979 |
| oral/mouse | 252 gm/kg (18W prior to copulation) | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | EVHPAZ 57,85,1984 |
| oral/mouse | 5600 mg/kg (8-14D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TCMUD8 7,55,1987 |
| oral/mouse | 12600 mg/kg (8-14D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Other developmental abnormalities | TJADAB 33,96C,1986 |
| skin/rat | 50 gm/kg (7-16D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | DCTODJ 5,277,1982 |
| skin/rat | 50 gm/kg (7-16D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | DCTODJ 5,277,1982 |
| skin/rat | 50 gm/kg (7-16D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Urogenital system | EVHPAZ 57,69,1984 |
| skin/rat | 12.5 mL/kg (7-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | VCVGK* -,163,1994 |
| subcutaneous/rat | 1955 mg/kg (1-21D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | ARZNAD 21,880,1971 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: >25 mmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 36,153,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 25 mmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 36,153,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 0.1 mmol/L/24H | Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TIVIEQ 36,153,2016 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 25 mmol/L/48H | Reproductive: Other effects to embryo or fetus | TIVIEQ 7,777,1993 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 100 mmol/L/48H | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TIVIEQ 7,777,1993 |
| In Vitro/Rat, embryo | Inhibitor Concentration Low: 25 mmol/L/48H | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Other developmental abnormalities | TIVIEQ 7,777,1993 |
| inhalation/guinea pig | Lowest published lethal concentration: 3000 ppm/24H | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness Lung, Thorax, or Respiration: Dyspnea | PHRPA6 45,1459,1930 |
| inhalation/mouse | Lowest published lethal concentration: 6500 mg/m3/7H | Lung, Thorax, or Respiration: Other changes Gastrointestinal: Ulceration or bleeding from stomach | VCVGK* -,162,1984 |
| inhalation/mouse | lethal concentration (50 percent kill): 1820 ppm/7H | Behavioral: Analgesia Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Hematuria | JIHTAB 25,157,1943 |
| inhalation/rat | lethal concentration (50 percent kill): 2000 ppm/7H | NPIRI* 1,54,1974 | |
| inhalation/rat | lethal concentration (50 percent kill): >4000 ppm/4H | IJTOFN 21,9,2002 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1710 mg/kg | Kidney, Ureter, and Bladder: Other changes | IJTOFN 21,9,2002 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1707 mg/kg | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen | FEPRA7 6,342,1947 |
| intraperitoneal/rat | lethal dose (50 percent kill): 2800 mg/kg | ARZNAD 21,880,1971 | |
| intravenous/mouse | lethal dose (50 percent kill): 3900 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | ARZNAD 21,880,1971 |
| intravenous/rabbit | lethal dose (50 percent kill): 900 mg/kg | Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | ARZNAD 21,880,1971 |
| intravenous/rat | lethal dose (50 percent kill): 2400 mg/kg | NPIRI* 1,54,1974 | |
| oral/guinea pig | lethal dose (50 percent kill): 1400 mg/kg | Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/guinea pig | lethal dose (50 percent kill): 950 mg/kg | Behavioral: General anesthetic | IJTOFN 21,9,2002 |
| oral/guinea pig | lethal dose (50 percent kill): 1.4 gm/kg | ENTOX* -,289,2005 | |
| oral/human | lowest published lethal dose: 143 mg/kg | VCVGK* -,163,1984 | |
| oral/mouse | lethal dose (50 percent kill): 2451 mg/kg | Behavioral: Tremor Behavioral: Coma Lung, Thorax, or Respiration: Respiratory stimulation | IJTOFN 21,9,2002 |
| oral/mouse | lethal dose (50 percent kill): 4000 mg/kg | Behavioral: Tetany Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,162,1984 |
| oral/mouse | lethal dose (50 percent kill): 2451 mg/kg | KODAK* MSDS-10,170A,1982 | |
| oral/rabbit | lethal dose (50 percent kill): 1275 mg/kg | GISAAA 53(10),78,1988 | |
| oral/rabbit | lethal dose (50 percent kill): 1275 mg/kg | Behavioral: Tetany Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,162,1984 |
| oral/rat | lethal dose (50 percent kill): 2125 mg/kg | Behavioral: Tetany Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,162,1984 |
| oral/rat | lethal dose (50 percent kill): 2460 mg/kg | Behavioral: General anesthetic | IJTOFN 21,9,2002 |
| oral/rat | lethal dose (50 percent kill): 3527 mg/kg | Behavioral: Tremor Behavioral: Coma Kidney, Ureter, and Bladder: Hematuria | IJTOFN 21,9,2002 |
| oral/rat | lethal dose (50 percent kill): 8103 mg/kg | Behavioral: Tremor Behavioral: Coma Lung, Thorax, or Respiration: Respiratory stimulation | IJTOFN 21,9,2002 |
| oral/rat | lowest published toxic dose: 1000 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TOXID9 44,111,2005 |
| oral/rat | lethal dose (50 percent kill): 3 gm/kg | ENTOX* -,289,2005 | |
| oral/rat | lethal dose (50 percent kill): 2125 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Withdrawal Lung, Thorax, or Respiration: Respiratory depression | GTPZAB 32(3),48,1988 |
| oral/woman | lowest published toxic dose: 0.8 mL/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,163,1984 |
| skin/rabbit | lethal dose (50 percent kill): 3.6 gm/kg | VCVGK* -,162,1984 | |
| skin/rat | lethal dose (50 percent kill): 3900 mg/kg | TOXID9 4,180,1984 | |
| subcutaneous/mouse | lowest published lethal dose: 5 gm/kg | JPETAB 42,355,1931 | |
| subcutaneous/rabbit | lethal dose (50 percent kill): 2 gm/kg | ARZNAD 21,880,1971 | |
| subcutaneous/rat | lethal dose (50 percent kill): 3400 mg/kg | ARZNAD 21,880,1971 | |
| unreported route/guinea pig | lethal dose (50 percent kill): 3070 mg/kg | GISAAA 47(5),84,1982 | |
| unreported route/mouse | lethal dose (50 percent kill): 5799 mg/kg | GISAAA 47(5),84,1982 | |
| unreported route/rat | lethal dose (50 percent kill): 7750 mg/kg | GISAAA 47(5),84,1982 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 840 ppm/7H/12W- intermittent | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Microcytosis with or without anemia Blood: Other changes | JIHTAB 25,409,1943 |
| inhalation/man | lowest published toxic concentration: 6.6 ppm/255W- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | BJIMAG 46,399,1989 |
| inhalation/rabbit | lowest published toxic concentration: 1470 mg/m3/6H/13W- intermittent | Blood: Normocytic anemia Blood: Changes in erythrocyte (RBC) count Eye: Lacrimation | VCVGK* -,163,1994 |
| inhalation/rabbit | lowest published toxic concentration: 1470 mg/m3/6H/13W- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Blood: Normocytic anemia Eye: Lacrimation | VCVGK* -,163,1994 |
| inhalation/rabbit | lowest published toxic concentration: 400 ppm/6H/13W- intermittent | Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | EVHPAZ 57,157,1984 |
| inhalation/rabbit | lowest published toxic concentration: 400 ppm/6H/13W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | NTIS** OTS0546061 |
| inhalation/rat | lowest published toxic concentration: 1400 mg/m3/7H/25D- intermittent | Blood: Changes in other cell count (unspecified) | VCVGK* -,163,1994 |
| inhalation/rat | lowest published toxic concentration: 1470 mg/m3/6H/13W- intermittent | Blood: Normocytic anemia Blood: Changes in erythrocyte (RBC) count Eye: Lacrimation | VCVGK* -,163,1994 |
| inhalation/rat | lowest published toxic concentration: 4000 ppm/4H/2W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AIHAAP 25,369,1964 |
| inhalation/rat | lowest published toxic concentration: 1370 mg/m3/7H/5W- intermittent | Blood: Changes in spleen | JIHTAB 25,374,1943 |
| oral/mouse | lowest published toxic dose: 25 gm/kg/2W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EVHPAZ 57,147,1984 |
| oral/mouse | lowest published toxic dose: 660 gm/kg/13W- continuous | Endocrine: Effect on menstrual cycle Endocrine: Other changes Blood: Changes in spleen | NTPTR* NIH-93-3349 |
| oral/mouse | lowest published toxic dose: 28840 mg/kg/8D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EVHPAZ 57,141,1984 |
| oral/mouse | lowest published toxic dose: 220.5 gm/kg/21W- continuous | Liver: Changes in liver weight | NTIS** #PB85118651 |
| oral/mouse | lowest published toxic dose: 382.2 gm/kg/21W- continuous | Brain and Coverings: Changes in brain weight Reproductive: Maternal effects: Menstrual cycle changes or disorders | NTIS** #PB85118651 |
| oral/mouse | lowest published toxic dose: 220.5 gm/kg/21W- continuous | Brain and Coverings: Changes in brain weight Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTIS** #PB85118651 |
| oral/mouse | lowest published toxic dose: 382.2 gm/kg/21W- continuous | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive: Paternal effects: Testes, epididymis, sperm duct | NTIS** #PB85118651 |
| oral/mouse | lowest published toxic dose: 8400 mg/kg/14D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in testicular weight | TOXID9 -,302,2009 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/2D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | EXMPA6 40,169,1984 |
| oral/rat | lowest published toxic dose: 18000 mg/kg/10D- intermittent | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count Blood: Changes in platelet count | HETOEA 24,95,2005 |
| oral/rat | lowest published toxic dose: 18000 mg/kg/10D- intermittent | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight | HETOEA 24,95,2005 |
| oral/rat | lowest published toxic dose: 342.5 mg/kg/137D- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,163,1994 |
| oral/rat | lowest published toxic dose: 342.5 mg/kg/137D- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,163,1994 |
| oral/rat | lowest published toxic dose: 4680 mg/kg/5D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | JJTHEC 13,763,1984 |
| oral/rat | lowest published toxic dose: 9360 mg/kg/5D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | JJTHEC 13,763,1984 |
| oral/rat | lowest published toxic dose: 14040 mg/kg/5D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JJTHEC 13,763,1984 |
| oral/rat | lowest published toxic dose: 7 mg/kg/2W- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,163,1994 |
| oral/rat | lowest published toxic dose: 2750 mg/kg/11D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | VCVGK* -,163,1994 |
| oral/rat | lowest published toxic dose: 17500 mg/kg/5W- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | REPTED 14,55,2000 |
| oral/rat | lowest published toxic dose: 8750 mg/kg/5W- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | REPTED 14,55,2000 |
| oral/rat | lowest published toxic dose: 24500 mg/kg/7W- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight | REPTED 14,55,2000 |
| oral/rat | lowest published toxic dose: 12250 mg/kg/7W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | REPTED 14,55,2000 |
| oral/rat | lowest published toxic dose: 3600 mg/kg/4W- intermittent | Endocrine: Changes in adrenal weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | TOLED5 109,11,1999 |
| oral/rat | lowest published toxic dose: 26452 mg/kg/6W- intermittent | Behavioral: Food intake (animal) Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0570960 |
| oral/rat | lowest published toxic dose: 25 gm/kg/2W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | EVHPAZ 57,147,1984 |
| oral/rat | lowest published toxic dose: 18655 mg/kg/13W- continuous | Endocrine: Changes in thymus weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | NTPTR* NIH-93-3349 |
| subcutaneous/rat | lowest published toxic dose: 9014 mg/kg/4W- intermittent | Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 82,125,2008 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FAATDF 13,747,1989 | |
| TOXICOLOGY REVIEW | CRTXB2 30,307,2000 | |
| TOXICOLOGY REVIEW | IJTOFN 21,9,2002 | |
| TOXICOLOGY REVIEW | CRTXB2 33,137,2003 | |
| TOXICOLOGY REVIEW | ENTOX* -,274,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,289,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,451,2005 | |
| TOXICOLOGY REVIEW | HUTOX* -,623,1996 | |
| TOXICOLOGY REVIEW | MUREAV 681,3,2009 | |
| TOXICOLOGY REVIEW | REPTED 34,298,2012 | |
| TOXICOLOGY REVIEW | REPTED 58,252,2015 | |
| TOXICOLOGY REVIEW | RTOPDW 61,105,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (370 mg/m3) (skin) | DTLWS* 3,18,1973 |
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (18 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (19 mg/m3);KZW 20 ppm (76 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (18 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (18.5 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 2 ppm (7.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (19 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 2 ppm (7.5 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 19 mg/m3, short term exposure limit 76 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (18.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 ppm (18 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (19 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 50 ppm (185 mg/m3);short term exposure limit 100 ppm (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (18 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (18 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (18 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 80 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 5 ppm (19 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (7.5 mg/m3), KZG-week 16 ppm (60 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 19 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 200 ppm (740 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 200 ppm (740 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 ppm (37 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 200 ppm (740 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 200 ppm (740 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 200 ppm (740 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 200 ppm (740 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOETHYL ETHER-air | 10H time-weighted average 0.5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 31350; Number of Industries 153; Total Number of Facilities 16505; Number of Occupations 106; Total Number of Employees Exposed 264436; Total Number of Female Employees Exposed 72493 | |
| National Occupational Hazard Survey 1974 | Hazard Code 31350; Number of Industries 253; Total Number of Facilities 43849; Number of Occupations 154; Total Number of Employees Exposed 406097 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health