Dipropylene glycol, monomethyl ether

RTECS #

JM1575000

CAS #

34590-94-8; 12002-25-4; 12002-35-6; 83730-60-3; 104512-57-4; 112388-78-0
See: NMAM or OSHA Methods

Updated

July 2016

Molecular Weight

148.23

Molecular Formula

C₇H₁₆O₃

Synonyms

1-(1-Methyl-2-methoxyethoxy)-2-propanol
1-(2-Methoxyisopropoxy)-2-propanol
1,4-Dimethyl-3,6-dioxa-1-heptanol
Arcosolv
Dipropylene glycol methyl ether
Dipropylene glycol methyl ether (ACGIH:OSHA)
Dowanol DPM
Dowanol-50B
Kino-red
Methyl dipropanol
Oxybispropanol methyl ether
Ucar solvent 2LM

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	8 mg	mild	JTOTDO 2,229,1983/1984
eye /rabbit	500 mg/24H	mild	85JCAE -,633,1986
skin /rabbit	500 mg open irritation test	mild	UCDS** 11/15/1971

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	lowest published toxic concentration: 3000 mg/m³	Behavioral: General anesthetic	VCVGK* -,175,1984
oral/Dog	lethal dose (50 percent kill): 7500 mg/kg	Lung, Thorax, or Respiration: Other changes	JPETAB 102,79,1951
oral/rat	lethal dose (50 percent kill): 5400 µL/kg		AMIHBC 9,509,1954
oral/rat	lethal dose (50 percent kill): 5.5 mL/kg		VCVGK* -,175,1984
skin/rabbit	lethal dose (50 percent kill): 10 mL/kg		AIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 2000 mg/m³/7H/26W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,175,1994
inhalation/monkey	lowest published toxic concentration: 2000 mg/m³/7H/26W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,175,1994
inhalation/rabbit	lowest published toxic concentration: 2000 mg/m³/7H/26W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,175,1994
inhalation/rat	lowest published toxic concentration: 2000 mg/m³/7H/26W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,175,1994
skin/rabbit	lowest published toxic dose: 650 mL/kg/13W- intermittent	Behavioral: General anesthetic Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	AMIHBC 9,509,1954

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 150 ppm (skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		ENTOX* -,451,2005
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		REPTED 58,252,2015

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 100 ppm (600 mg/m³) (skin)	DTLVS* 3,96,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 50 ppm (308 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (307 mg/m³);KZW 100 ppm (614 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 50 ppm (308 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 50 ppm (300 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 308 mg/m³ (50 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 50 ppm (310 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 50 ppm (308 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 50 ppm (310 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 308 mg/m³, short term exposure limit 308 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 50 ppm (300 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 100 ppm (600 mg/m³), short term exposure limit 150 ppm (900 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 100 ppm (60 mg/m³);short term exposure limit 150 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 100 ppm (606 mg/m³); short term exposure limit 150 ppm (909 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 100 ppm (606 mg/m³); short term exposure limit 150 ppm (909 mg/m³), JUL2005
Occupational Exposure Limit-SWEDEN	time-weighted average 50 ppm (300 mg/m³);short term exposure limit 75 ppm (450 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 50 ppm (300 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 300 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 100 ppm (600 mg/m³), Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 300 ppm (600 mg/m³), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 50 ppm (308 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 100 ppm (600 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 100 ppm (600 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 100 ppm (600 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 100 ppm (600 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air	10H time-weighted average 100 ppm (Sk);short term exposure limit 150 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84537; Number of Industries 123; Total Number of Facilities 15846; Number of Occupations 89; Total Number of Employees Exposed 210740; Total Number of Female Employees Exposed 21792
National Occupational Hazard Survey 1974	Hazard Code 84537; Number of Industries 66; Total Number of Facilities 5594; Number of Occupations 55; Total Number of Employees Exposed 52536

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #101

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health