Crotonaldehyde
RTECS #
GP9499000
CAS #
Updated
December 2018
Molecular Weight
70.10
Molecular Formula
C4H6O
Synonyms
1-Formylpropene
2-Butenal
2-Butenal (9CI)
2-Butenaldehyde
beta-Methylacrolein
Crotonal
Crotonaldehyde (ACGIH:OSHA)
Crotonic aldehyde
Krotonaldehyd (Czech)
Methylpropenal
RCRA waste number U053
2-Butenal
2-Butenal (9CI)
2-Butenaldehyde
beta-Methylacrolein
Crotonal
Crotonaldehyde (ACGIH:OSHA)
Crotonic aldehyde
Krotonaldehyd (Czech)
Methylpropenal
RCRA waste number U053
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
Cytogenetic Analysis | ovary/hamster | 1600 µg/L | EMMUEG 10(Suppl 10),1,1987 |
DNA adduct | lymphocyte/mammal (species unspecified) | 21500 mg/L/16H | CNREA8 44,990,1984 |
DNA adduct | fibroblast/human | 100 µmol/L | CRNGDP 12,1483,1991 |
DNA adduct | other cell types/cattle | 0.4 mmol/plate/96H | CRTOEC 14,423,2001 |
heritable translocation test | oral/Drosophila melanogaster | 25 mmol/L/48H | FCTOD7 53,221,2013 |
heritable translocation test | parenteral/Drosophila melanogaster | 3500 ppm | ENMUDM 7,677,1985 |
micronucleus test | ovary/hamster | 66.9 µmol/L/3H (+enzymatic activation step) | MUREAV 751,1,2013 |
micronucleus test | ovary/hamster | 22.3 µmol/L/24H (-enzymatic activation step) | MUREAV 630,1,2007 |
mutation in microorganisms | /Saccharomyes cerevisiae | 85.2 mg/L/16H | MUTAEX 20,105,2004 |
mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (+enzymatic activation step) | EMMUEG 14,146,1989 |
mutation in microorganisms | /Salmonella typhimurium | 10 µg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
mutation in microorganisms | /Escherichia coli | 75 nmol/plate | MUREAV 516,81,2002 |
sex chromosome loss and nondisjunction | parenteral/Drosophila melanogaster | 3500 ppm | ENMUDM 7,677,1985 |
sister chromatid exchange | ovary/hamster | 500 µg/L | EMMUEG 10(Suppl 10),1,1987 |
specific locus test | other cell types/mouse | 25 µmol/L/4H (-enzymatic activation step) | MUREAV 726,98,2011 |
Tumorigenic Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 2664 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | CNREA8 46,1285,1986 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
In Vitro/Human, lung | Inhibitor Concentration Low: 150 µmol/L/3H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 195,90,2010 |
In Vitro/Human, lung | Inhibitor Concentration Low: 70 µmol/L/9H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 195,90,2010 |
In Vitro/Human, lung | Inhibitor Concentration Low: 10 µmol/L/3H | In Vitro Toxicity Studies: Other assays | TOLED5 195,90,2010 |
In Vitro/Human, lung | Inhibitor Concentration Low: 70 µmol/L/3H | In Vitro Toxicity Studies: Apoptosis in vitro | TOLED5 195,90,2010 |
inhalation/human | lowest published toxic concentration: 25 mg/m3 | Olfaction: Other olfaction effects | VCVGK* -,390,1984 |
inhalation/human | lowest published toxic concentration: 40 mg/m3/10S | Eye: Conjunctiva irritation | VCVGK* -,390,1984 |
inhalation/human | lowest published toxic concentration: 8 mg/m3 | Eye: Conjunctiva irritation | VCVGK* -,390,1984 |
inhalation/mouse | lethal concentration (50 percent kill): 580 mg/m3/2H | GTPZAB 26(8),53,1982 | |
inhalation/rat | lethal concentration (50 percent kill): 200 mg/m3/2H | GTPZAB 26(8),53,1982 | |
inhalation/rat | lethal concentration (50 percent kill): 9600 mg/m3/5M | VCVGK* -,390,1984 | |
inhalation/rat | lethal concentration (50 percent kill): 4800 mg/m3/10M | VCVGK* -,390,1984 | |
inhalation/rat | lethal concentration (50 percent kill): 2400 mg/m3/15M | VCVGK* -,390,1984 | |
inhalation/rat | lethal concentration (50 percent kill): 1700 mg/m3/30M | VCVGK* -,390,1984 | |
inhalation/rat | lethal concentration (50 percent kill): 1100 mg/m3/60M | VCVGK* -,390,1984 | |
inhalation/rat | lethal concentration (50 percent kill): 300 mg/m3/4H | VCVGK* -,390,1984 | |
inhalation/rat | lowest published toxic concentration: 87 mg/kg/4H | Cardiac: Other changes Blood: Other changes | TOLED5 135,S143,2002 |
inhalation/rat | lowest published toxic concentration: 5 mg/m3/4H | Vascular: Other changes Lung, Thorax, or Respiration: Other changes | TOVEFN (6),36,1998 |
intravenous/cat | lowest published lethal dose: 30 mg/kg | Blood: Other changes | APTOA6 8,275,1952 |
oral/mouse | lethal dose (50 percent kill): 104 mg/kg | GTPZAB 26(8),53,1982 | |
oral/rat | lethal dose (50 percent kill): 80 mg/kg | Cardiac: Pulse rate increased without fall in BP Lung, Thorax, or Respiration: Cyanosis Nutritional and Gross Metabolic: Body temperature decrease | GISAAA 62(3),3,1997 |
skin/guinea pig | lethal dose (50 percent kill): 30 µL/kg | JIHTAB 26,269,1944 | |
skin/rabbit | lethal dose (50 percent kill): 380 µL/kg | UCDS** 4/21/1967 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 20 mg/m3/7H/8W- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other proteins | GTPZAB 18(6),55,1974 |
intratracheal/rat | lowest published toxic dose: 5 mg/m3/13W- intermittent | Lung, Thorax, or Respiration: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,390,1994 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 0.3 ppm (skin) | DTLVS* TLV/BEI,2013 |
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 63,373,1995 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 63,373,1995 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 63,373,1995 |
TOXICOLOGY REVIEW | MUREAV 544,115,2003 | |
TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
TOXICOLOGY REVIEW | MUTAEX 19,169,2004 | |
TOXICOLOGY REVIEW | MUREAV 659,56,2008 | |
TOXICOLOGY REVIEW | MUREAV 659,68,2008 | |
TOXICOLOGY REVIEW | MUREAV 690,3,2010 | |
TOXICOLOGY REVIEW | MUREAV 711,13,2011 | |
TOXICOLOGY REVIEW | EMMUEG 55,77,2014 | |
TOXICOLOGY REVIEW | FCTOD7 106,609,2017 | |
TOXICOLOGY REVIEW | RTOPDW 54,247,2009 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 2 ppm (6 mg/m3) | DTLVS* 3,62,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (5.7 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | TRK-TMW 0.34 ppm (1 mg/m3);KZW 1.36 ppm (4 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | short term exposure limit 0.3 ppm (0.87 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 2 ppm (6 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.29 mg/m3), short term exposure limit 0.3 ppm (0.87 mg/m3), NOV2011 | |
Occupational Exposure Limit-ICELAND | time-weighted average 2 ppm (6 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (6 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (6 mg/m3);short term exposure limit 6 ppm (18 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 2 ppm (5.7 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-POLAND | time-weighted average 6 mg/m3, short term exposure limit 12 mg/m3, JAN1999 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 2 ppm (6 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 2 ppm (6 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 2 ppm (6 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 2 ppm (6 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 2 ppm (6 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health