Coumarin, 3-(alpha-acetonylbenzyl)-4-hydroxy-
RTECS #
GN4550000
CAS #
Updated
March 2019
Molecular Weight
308.35
Molecular Formula
C19H16O4
Synonyms
(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine (French)
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- (9CI)
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin (German)
3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine (Dutch)
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin (German)
4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine (Italian)
Arab Rat Deth
Athrombine-K
Athrombin-K
Brumolin
Compound 42
CO-Rax
Coumadin
Coumafen
Coumafene
Coumarins
Coumefene
Cov-R-Tox
d-Con
Dethmor
Dethnel
Eastern states duocide
Fasco fascrat powder
Kumader
Kumadu
Kypfarin
Latka 42 (Czech)
Liqua-tox
Mar-frin
Martin's mar-frin
Maveran
Mouse pak
Rat & mice bait
Rat-B-gon
Rat-Gard
Rat-Kill
Rat-Mix
Rat-O-cide #2
Rat-ola
Ratorex
Ratoxin
Ratron
Ratron G
Rats-No-More
Rat-Trol
Rattunal
RCRA waste number P001
Rodafarin
Ro-Deth
Rodex blox
Rough & ready mouse mix
Solfarin
Spray-trol brand roden-trol
Temus W
Twin light rat away
Vampirinip II
Vampirinip III
W.A.R.F. 42
Warf compound 42
Warfarat
Warfarin
Warfarin (ACGIH:OSHA)
Warfarin plus
Warfarin Q
Warfarine (French)
Warficide
Zoocoumarin (Russian)
1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone
2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)- (9CI)
3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin
3-(Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin
3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin (German)
3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin
4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine (Dutch)
4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin (German)
4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine (Italian)
Arab Rat Deth
Athrombine-K
Athrombin-K
Brumolin
Compound 42
CO-Rax
Coumadin
Coumafen
Coumafene
Coumarins
Coumefene
Cov-R-Tox
d-Con
Dethmor
Dethnel
Eastern states duocide
Fasco fascrat powder
Kumader
Kumadu
Kypfarin
Latka 42 (Czech)
Liqua-tox
Mar-frin
Martin's mar-frin
Maveran
Mouse pak
Rat & mice bait
Rat-B-gon
Rat-Gard
Rat-Kill
Rat-Mix
Rat-O-cide #2
Rat-ola
Ratorex
Ratoxin
Ratron
Ratron G
Rats-No-More
Rat-Trol
Rattunal
RCRA waste number P001
Rodafarin
Ro-Deth
Rodex blox
Rough & ready mouse mix
Solfarin
Spray-trol brand roden-trol
Temus W
Twin light rat away
Vampirinip II
Vampirinip III
W.A.R.F. 42
Warf compound 42
Warfarat
Warfarin
Warfarin (ACGIH:OSHA)
Warfarin plus
Warfarin Q
Warfarine (French)
Warficide
Zoocoumarin (Russian)
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intramuscular/woman | 12 mg/kg (27-31W pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | JMSHAO 26,562,1959 |
| intramuscular/rabbit | 10 mg/kg (8-28D pregnant) | Reproductive: Other developmental abnormalities Reproductive: Effects on newborn: Stillbirth | BLOOAW 36,623,1970 |
| intravenous/mouse | 240 mg/kg (2-3D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | CCPTAY 3,279,1971 |
| oral/woman | 980 mg/kg (98-168D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | JKMSEH 18,764,2003 |
| oral/woman | 28 mg/kg (1-20W pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | ADCHAK 55,139,1980 |
| oral/woman | 8400 µg/kg (1-8W pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | AJOGAH 127,191,1977 |
| oral/woman | 33600 µg/kg (1-32W pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Respiratory system Reproductive: Effects on newborn: Physical | AJOGAH 127,191,1977 |
| unreported route/woman | 6450 µg/kg (27-33W pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | JMSHAO 26,562,1959 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 5170 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 2825 µmol/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (50 percent kill): 2263 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
| In Vitro/Chicken, neurons | Inhibitor Concentration (10 percent kill): 610 µmol/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 7,653,1993 |
| In Vitro/Human, liver | Inhibitor Concentration (50 percent kill): >200 µmol/L/48H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 30,429,2015 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 894 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): >250 µmol/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 29,582,2015 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 1030 mg/L | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Human, skin | Inhibitor Concentration (50 percent kill): 126 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 245 mg/L/48H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 469 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): >100 µmol/L/24H | In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc. | TIVIEQ 30,429,2015 |
| In Vitro/mpe | Inhibitor Concentration (50 percent kill): >200 µmol/L/48H | In Vitro Toxicity Studies: Other assays | TIVIEQ 25,1934,2011 |
| In Vitro/paa | Inhibitor Concentration Low: 165 µmol/L/44H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,1416,2013 |
| In Vitro/Pig, spermatozoa | Inhibitor Concentration (50 percent kill): >1000 µmol/L/30M | In Vitro Toxicity Studies: Other assays | TIVIEQ 29,582,2015 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 387 mg/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,1347,2013 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 391 mg/L/20H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 392 mg/L/20H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 428 mg/L/20H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver | Inhibitor Concentration (50 percent kill): 269 mg/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): 784 mg/L/20H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): 639 mg/L/20H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): 809 mg/L/20H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 5,543,1991 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration (50 percent kill): 743 mg/L/20H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. | TIVIEQ 5,543,1991 |
| inhalation/rat | lethal concentration (50 percent kill): 320 mg/m3 | GTPZAB 22(7),49,1978 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 750 mg/kg | EJMCA5 30,531,1995 | |
| intraperitoneal/rat | lowest published lethal dose: 420 mg/kg | TXAPA9 1,156,1959 | |
| intravenous/mouse | lethal dose (50 percent kill): 165 mg/kg | 27ZIAQ -,274,1973 | |
| oral/cat | lethal dose (50 percent kill): 6 mg/kg | DEVEAA 32,27,1978 | |
| oral/chicken | lethal dose (50 percent kill): 942 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Lung, Thorax, or Respiration: Dyspnea Blood: Hemorrhage | BECTA6 37,544,1986 |
| oral/Dog | lethal dose (50 percent kill): 3 mg/kg | DEVEAA 43(255-256),20,1989 | |
| oral/guinea pig | lethal dose (50 percent kill): 180 mg/kg | DEVEAA 32,27,1978 | |
| oral/human | lowest published lethal dose: 6667 µg/kg | YKYUA6 28,329,1977 | |
| oral/man | lowest published toxic dose: 10200 µg/kg | Blood: Hemorrhage | CMEP** -,1,1956 |
| oral/mouse | lethal dose (50 percent kill): 3 mg/kg | DEVEAA 43(255-256),20,1989 | |
| oral/pig | lethal dose (50 percent kill): 1 mg/kg | DEVEAA 32,27,1978 | |
| oral/rabbit | lethal dose (50 percent kill): 800 mg/kg | DEVEAA 32,27,1978 | |
| oral/rat | lethal dose (50 percent kill): 1600 µg/kg | TXAPA9 11,327,1967 | |
| oral/woman | lowest published toxic dose: 250 µg/kg/2D- intermittent | Vascular: Structural changes in vessels | AJEMEN 16,541,1998 |
| oral/woman | lowest published toxic dose: 15 mg/kg/21W- intermittent | Gastrointestinal: Ulceration or bleeding from small intestine Blood: Change in clotting factors | SMJOAV 75,242,1982 |
| skin/rat | lethal dose (50 percent kill): 1400 mg/kg | Eye: Chromodacryorrhea Behavioral: Muscle weakness Kidney, Ureter, and Bladder: Hematuria | GTPZAB 22(7),49,1978 |
| skin/rat | lowest published toxic dose: 50 µg/kg | Biochemical: Metabolism (intermediary): Lipids including transport Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXCYAC 212,206,2005 |
| subcutaneous/mouse | lowest published lethal dose: 800 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) | TIVSAI 58,122,1977 |
| unreported route/mouse | lethal dose (50 percent kill): 60 mg/kg | YKYUA6 30,397,1979 | |
| unreported route/rat | lethal dose (50 percent kill): 50 mg/kg | YKYUA6 30,397,1979 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 16 mg/m3/4H/30D- intermittent | Blood: Normocytic anemia Blood: Changes in erythrocyte (RBC) count Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | GTPZAB 22(7),49,1978 |
| intraperitoneal/rat | lowest published toxic dose: 10 mg/kg/2D- intermittent | Liver: Other changes Blood: Change in clotting factors | TXAPA9 180,186,2002 |
| intraperitoneal/rat | lowest published toxic dose: 0.3 mg/kg/3D- intermittent | Nutritional and Gross Metabolic: Changes in: K | TOXID9 44,106,2005 |
| intraperitoneal/rat | lowest published toxic dose: 20 mg/kg/2D- intermittent | Liver: Other changes | TXCYAC 225,128,2006 |
| oral/Dog | lowest published toxic dose: 12 mg/kg/6D- intermittent | Blood: Change in clotting factors Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | YKYUA6 31,1385,1980 |
| oral/human | lowest published toxic dose: 4.35 mg/kg/15D- intermittent | Blood: Hemorrhage | HBPTO* 1,60,2001 |
| oral/mammal (species unspecified) | lowest published toxic dose: 686 mg/kg/28D- continuous | Behavioral: Food intake (animal) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AECTCV 16,357,1987 |
| oral/man | lowest published toxic dose: 12.9 mg/kg/24W- intermittent | Blood: Hemorrhage | JTCTDW 46,765,2008 |
| oral/mouse | lowest published toxic dose: 4.5 mg/kg/3D- intermittent | Blood: Change in clotting factors | PYTOEY 19,177,2012 |
| oral/pig | lowest published toxic dose: 1 mg/kg/5D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | AJVRAH 43,1387,1982 |
| oral/rat | lowest published toxic dose: 11250 µg/kg/90D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOLED5 1000(Suppl 1),141,1980 |
| oral/rat | lowest published toxic dose: 17800 µg/kg/10D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | ESDBAK 32,251,1981 |
| oral/rat | lowest published toxic dose: 0.9 mg/kg/3D- intermittent | Blood: Change in clotting factors | JPETAB 324,497,2008 |
| oral/rat | lowest published toxic dose: 1 mg/kg/5D- intermittent | Blood: Change in clotting factors | JOETD7 143,648,2012 |
| oral/rat | lowest published toxic dose: 10800 µg/kg/30D- continuous | Blood: Hemorrhage Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTOD7 50,1499,2012 |
| oral/rat | lowest published toxic dose: 1050 µg/kg/30D- continuous | Blood: Other changes Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | FCTOD7 50,1499,2012 |
| oral/rat | lowest published toxic dose: 3.2 mg/kg/40D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HBPTO* 1,60,2001 |
| oral/rat | lowest published toxic dose: 275.2 mg/kg/4D- continuous | Behavioral: Food intake (animal) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | VHTODE 43,327,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | BJOPAL 64,633,1980 | |
| TOXICOLOGY REVIEW | AJHGAG 30,104A,1978 | |
| TOXICOLOGY REVIEW | AJMEAZ 68,122,1980 | |
| TOXICOLOGY REVIEW | VHTODE 43,353,2001 | |
| TOXICOLOGY REVIEW | TJADAB 66,127,2002 | |
| TOXICOLOGY REVIEW | MUREAV 488,151,2001 | |
| TOXICOLOGY REVIEW | TPHSDY 23,358,2002 | |
| TOXICOLOGY REVIEW | EMMUEG 43,143,2004 | |
| TOXICOLOGY REVIEW | TPHSDY 24,589,2003 | |
| TOXICOLOGY REVIEW | APHRER 38,99,2004 | |
| TOXICOLOGY REVIEW | APHRER 38,2115,2004 | |
| TOXICOLOGY REVIEW | AUIMR* 1,183,2002 | |
| TOXICOLOGY REVIEW | DIMON* 40,258,1994 | |
| TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
| TOXICOLOGY REVIEW | ENTOX* -,461,2005 | |
| TOXICOLOGY REVIEW | APHRER 40,2101,2006 | |
| TOXICOLOGY REVIEW | MJAUAJ 178,413,2003 | |
| TOXICOLOGY REVIEW | HUTOX* -,561,1996 | |
| TOXICOLOGY REVIEW | COCPH* -,701,2008 | |
| TOXICOLOGY REVIEW | HTCWA* 2,207, | |
| TOXICOLOGY REVIEW | CCACL* 22,357,2006 | |
| TOXICOLOGY REVIEW | DERCL* 25,215,2007 | |
| TOXICOLOGY REVIEW | TXAPA9 243,134,2010 | |
| TOXICOLOGY REVIEW | FCLPH* 22(Suppl 1),64,2008 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | RTOPDW 58,395,2010 | |
| TOXICOLOGY REVIEW | FCTOD7 113,19,2018 | |
| TOXICOLOGY REVIEW | SFDRA* 38,365,2016 | |
| TOXICOLOGY REVIEW | SFDRA* 38,379,2016 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | RED Completed | RBREV* -,156,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 mg/m3 | DTLVS* 3,279,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 mg/m3;KZW 0.5 mg/m3, inhal, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 mg/m3, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,1 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.001 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.0016 ppm (0.02 mg/m3), KZG-week 0.0128 ppm, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 0.1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 mg/m3, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.1 mg/m3, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO WARFARIN-air | 10H time-weighted average 0.1 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 76610; Number of Industries 6; Total Number of Facilities 446; Number of Occupations 8; Total Number of Employees Exposed 6131; Total Number of Female Employees Exposed 1874 | |
| National Occupational Hazard Survey 1974 | Hazard Code 76610; Number of Industries 3; Total Number of Facilities 2535; Number of Occupations 5; Total Number of Employees Exposed 26783 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Warfarin, 5002 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health