Acetone

RTECS #

AL3150000

CAS #

67-64-1
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

58.09

Molecular Formula

C₃H₆O

Synonyms

2-Propanone
Aceton (German, Dutch, Polish)
Acetone (ACGIH:OSHA)
beta-Ketopropane
Chevron acetone
Dimethyl ketone
Dimethylformaldehyde
Dimethylketal
Ketone propane
Ketone, dimethyl
Methyl ketone
Propanone
Pyroacetic acid
Pyroacetic ether
RCRA waste number U002

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	500 ppm		JIHTAB 25,282,1943
eye /human	186300 ppm	mild	CRTXB2 32,43,2002
eye /rabbit	20 mg	severe	ENTOX* -,27,2005
eye /rabbit	20 mg/24H	moderate	85JCAE -,280,1986
eye /rabbit	10 µL	mild	JTPAE7 29,187,2001
skin /rabbit	395 mg open irritation test	mild	UCDS** 5/7/1970
skin /rabbit	500 mg/24H	mild	85JCAE -,280,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	fibroblast/hamster	40 gm/L	FCTOD7 22,623,1984
sex chromosome loss and nondisjunction	inhalation/mouse	12 gm/L	VCVGK* -,409,1994
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	47600 ppm	ANYAA9 407,186,1983

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mammal (species unspecified)	31500 µg/m³/24H (1-13D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	GTPZAB 26(6),24,1982
inhalation/rat	30 mg/m³ (1-13D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetal death	VCVGK* -,409,1994
inhalation/rat	11000 ppm (6-19D pregnant)	Reproductive: Other developmental abnormalities	NTIS** #DE89-005671
inhalation/mouse	6600 ppm (6-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	NTIS** #DE89-005671
oral/rat	273 gm/kg (13W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	NTIS** PB91-185975

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 355 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 546 gm/L/3H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 231 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 27,174,2013
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 402 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Human, lung	Inhibitor Concentration (50 percent kill): 225 gm/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,174,2013
In Vitro/Human, lung tumor	Inhibitor Concentration (50 percent kill): 59 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 27,174,2013
In Vitro/Human, lung tumor	Inhibitor Concentration (50 percent kill): 54 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Human, skin	Inhibitor Concentration Low: 60 µL/well/60M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1476,2013
In Vitro/jda	Inhibitor Concentration (50 percent kill): 148597 mg/L/1H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 212,198,2012
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 24 gm/L/24H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 23 gm/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,174,2013
In Vitro/Non-mammalian species, fibroblast	Inhibitor Concentration (50 percent kill): 620 mmol/L/24H	In Vitro Toxicity Studies: Cell counting	TIVIEQ 7,537,1993
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 25,1425,2011
In Vitro/Rabbit, ocular	Inhibitor Concentration (50 percent kill): 0.024 gm/L/10M	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TIVIEQ 3,329,1989
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 1445.4 mmol/L/1H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 32,347,2016
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 3311.3 mmol/L/1H	In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)	TIVIEQ 32,347,2016
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 2818.4 mmol/L/1H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 32,347,2016
In Vitro/Rat, lung	Inhibitor Concentration (50 percent kill): 1584.9 mmol/L/1H	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TIVIEQ 32,347,2016
inhalation/cat	lowest published toxic concentration: 8000 mg/m³	Eye: Conjunctiva irritation Behavioral: Sleep	VCVGK* -,408,1984
inhalation/guinea pig	lowest published toxic concentration: 72000 mg/m³/2H	Behavioral: Alteration of classical conditioning	VCVGK* -,408,1984
inhalation/human	lowest published toxic concentration: 12000 mg/m³/3M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,408,1984
inhalation/human	lowest published toxic concentration: 10 mg/m³/6H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	VCVGK* -,408,1984
inhalation/human	lowest published toxic concentration: 500 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
inhalation/man	lowest published toxic concentration: 12000 ppm/4H	Gastrointestinal: Nausea or vomiting Behavioral: Muscle weakness	AOHYA3 16,73,1973
inhalation/man	lowest published toxic concentration: 440 µg/m³/6M	Brain and Coverings: Recordings from specific areas of CNS	GISAAA 42(8),42,1977
inhalation/man	lowest published toxic concentration: 10 mg/m³/6H	Biochemical: Metabolism (intermediary): Other carbohydrates	GISAAA 42(8),42,1977
inhalation/mouse	lethal concentration (50 percent kill): 44 gm/m³/4H		CUTOEX 1,47,1993
inhalation/mouse	Lowest published lethal concentration: 150000 mg/m³		VCVGK* -,408,1984
inhalation/mouse	lowest published toxic concentration: 10000 ppm/6M	Lung, Thorax, or Respiration: Respiratory depression	TOLED5 9,137,1981
inhalation/mouse	lowest published toxic concentration: 30000 mg/m³/2H	Behavioral: Alteration of classical conditioning	VCVGK* -,408,1984
inhalation/rabbit	lowest published toxic concentration: 1250 mg/m³	Behavioral: Alteration of classical conditioning	VCVGK* -,408,1984
inhalation/rat	lowest published toxic concentration: 30000 mg/m³/2H	Behavioral: Alteration of classical conditioning	VCVGK* -,408,1984
inhalation/rat	lethal concentration (50 percent kill): 50100 mg/m³/8H		AIHAAP 20,364,1959
inhalation/rat	lethal concentration (50 percent kill): 50100 mg/m³		ENTOX* -,27,2005
inhalation/rat	lowest published toxic concentration: 20000 ppm/1H	Behavioral: Change in motor activity (specific assay)	PBBHAU 89,101,2008
intraperitoneal/Dog	lowest published lethal dose: 8 gm/kg	Behavioral: Coma Gastrointestinal: Alteration in gastric secretion	AEXPBL 18,218,1884
intraperitoneal/mouse	lethal dose (50 percent kill): 1297 mg/kg		SCCUR* -,1,1961
intraperitoneal/rat	lowest published lethal dose: 500 mg/kg	Behavioral: General anesthetic Behavioral: Muscle weakness Kidney, Ureter, and Bladder: Renal function tests depressed	JPPMAB 11,150,1959
intraperitoneal/rat	lowest published toxic dose: 1452 mg/kg	Behavioral: Anticonvulsant	BJPCBM 158,872,2009
intravenous/mouse	lowest published lethal dose: 4 gm/kg		FAONAU 48A,86,1970
intravenous/rabbit	lowest published lethal dose: 1576 mg/kg	Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
intravenous/rat	lethal dose (50 percent kill): 5500 mg/kg		NPIRI* 1,1,1974
oral/Dog	lowest published lethal dose: 8 gm/kg	Behavioral: Ataxia Behavioral: Coma Musculoskeletal: Joints	AEXPBL 18,218,1884
oral/Dog	lowest published lethal dose: 8000 mg/kg		VCVGK* -,408,1984
oral/human	lowest published lethal dose: 714 mg/kg		VCVGK* -,409,1984
oral/mammal (species unspecified)	lowest published toxic dose: 3.49 gm/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Effect on specific coenzyme: NAD, NADP	VCVGK* -,408,1984
oral/man	lowest published toxic dose: 2857 mg/kg	Behavioral: Coma Kidney, Ureter, and Bladder: Other changes	34ZIAG -,64,1969
oral/man	lowest published toxic dose: 2857 mg/kg	Behavioral: Coma Biochemical: Metabolism (intermediary): Other	DIAEAZ 15,810,1966
oral/mouse	lethal dose (50 percent kill): 3 gm/kg		PCJOAU 14,162,1980
oral/rabbit	lethal dose (50 percent kill): 5340 mg/kg		FAONAU 48A,86,1970
oral/rat	lowest published toxic dose: 5 mL/kg	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	TOXID9 60,404,2001
oral/rat	lethal dose (50 percent kill): 5800 mg/kg		ENTOX* -,27,2005
oral/rat	lethal dose (50 percent kill): 5800 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Tremor	JTEHD6 15,609,1985
skin/guinea pig	lethal dose (50 percent kill): >9400 µL/kg		TXAPA9 7,559,1965
skin/rabbit	lowest published lethal dose: 20 mL/kg		UCDS** 5/7/1970
subcutaneous/Dog	lowest published lethal dose: 5 gm/kg		AEXPBL 18,218,1884
subcutaneous/guinea pig	lowest published lethal dose: 5 gm/kg		AGGHAR 5,1,1933
unreported route/man	lowest published lethal dose: 1159 mg/kg		85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 100 mg/m³/6H/5D- intermittent	Cardiac: EKG changes not diagnostic of above Cardiac: Pulse rate increased without fall in BP Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	VCVGK* -,409,1994
inhalation/human	lowest published toxic concentration: 440 mg/m³/3Y- intermittent	Blood: Changes in erythrocyte (RBC) count Blood: Granulocytopenia	VCVGK* -,410,1994
inhalation/mouse	lowest published toxic concentration: 11000 ppm/12D- intermittent	Behavioral: General anesthetic	NTIS** #DE89-005671
inhalation/rat	lowest published toxic concentration: 206 mg/m³/21D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Reproductive: Other effects on female	GISAAA 4,12,1994
inhalation/rat	lowest published toxic concentration: 11000 ppm/9D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #DE89-005671
inhalation/rat	lowest published toxic concentration: 30 mg/m³/13D- intermittent	Biochemical: Metabolism (intermediary): Lipids including transport	VCVGK* -,409,1994
inhalation/rat	lowest published toxic concentration: 5000 ppm/3D- intermittent	Behavioral: Change in motor activity (specific assay)	PBBHAU 89,101,2008
inhalation/rat	lowest published toxic concentration: 2000 mg/m³/4H/45D- intermittent	Endocrine: Change in gonadotropins Endocrine: Evidence of thyroid hyperfunction Biochemical: Metabolism (intermediary): Effect on Na-K pump	VCVGK* -,409,1994
inhalation/rat	lowest published toxic concentration: 199 mg/m³/8H/45D- intermittent	Behavioral: Alteration of classical conditioning	VCVGK* -,409,1994
inhalation/rat	lowest published toxic concentration: 19000 ppm/3H/8W- intermittent	Brain and Coverings: Changes in brain weight	TXAPA9 61,302,1981
inhalation/rat	lowest published toxic concentration: 199 mg/m³/8H/45D- intermittent	Behavioral: Muscle contraction or spasticity	GISAAA 25(5),3,1960
oral/mouse	lowest published toxic dose: 546 gm/kg/13W- continuous	Liver: Changes in liver weight Endocrine: Changes in spleen weight	NTPTR* NIH-91-3122
oral/mouse	lowest published toxic dose: 2 mg/kg/5D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	LIFSAK 69,923,2001
oral/rat	lowest published toxic dose: 273 gm/kg/13W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Normocytic anemia	NTPTR* NIH-91-3122
oral/rat	lowest published toxic dose: 5 mg/kg/5D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	LIFSAK 69,923,2001
oral/rat	lowest published toxic dose: 7 gm/kg/7D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	BCPCA6 67,875,2004
oral/rat	lowest published toxic dose: 15 mL/kg/3D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	TOLED5 144,55,2003
oral/rat	lowest published toxic dose: 8.75 mL/kg/7D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport	CBCPAI 128,503,2001
oral/rat	lowest published toxic dose: 145600 mg/kg/13W- continuous	Kidney, Ureter, and Bladder: Other changes Blood: Macrocytosis Blood: Other hemolysis with or without anemia	TOXID9 60,432,2001
skin/mouse	lowest published toxic dose: 31.6 µg/kg/2W- intermittent	Biochemical: Metabolism (intermediary): Other	MOCAE8 44,122,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 500 ppm;short term exposure limit 750 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		TOLED5 127,111,2002
TOXICOLOGY REVIEW		CRTXB2 32,43,2002
TOXICOLOGY REVIEW		MUREAV 566,209,2004
TOXICOLOGY REVIEW		CHHSA* 9,6,2002
TOXICOLOGY REVIEW		ENTOX* -,27,2005
TOXICOLOGY REVIEW		REPTED 25,192,2008
TOXICOLOGY REVIEW		MUREAV 659,93,2008
TOXICOLOGY REVIEW		HUTOX* -,577,1996
TOXICOLOGY REVIEW		MUREAV 674,62,2009
TOXICOLOGY REVIEW		NCLNA* 16,503,1998
TOXICOLOGY REVIEW		NTAPM* -,629,1995
TOXICOLOGY REVIEW		NTAPM* -,727,1995
TOXICOLOGY REVIEW		REPTED 58,252,2015
TOXICOLOGY REVIEW		FCTOD7 94,93,2016
TOXICOLOGY REVIEW		MUREAV 770,92,2016
TOXICOLOGY REVIEW		MUREAV 770,170,2016
TOXICOLOGY REVIEW		REPTED 61,120,2016
TOXICOLOGY REVIEW		TIVIEQ 36,105,2016
TOXICOLOGY REVIEW		RTOPDW 59,364,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,289,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1000 ppm (2400 mg/m³)	DTLVS* 3,3,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 500 ppm (1185 mg/m³), short term exposure limit 1000 ppm (2375 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 500 ppm (1200 mg/m³);KZW 2000 ppm (4800 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 500 ppm (1210 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 1000 ppm (2420 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 250 ppm (600 mg/m³), MAY2011
Occupational Exposure Limit-EC	time-weighted average 1210 mg/m³ (500 ppm), JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 500 ppm (1200 mg/m³), short term exposure limit 630 ppm (1500 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 500 ppm (1210 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 500 ppm (1200 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 1210 mg/m³, short term exposure limit 2420 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 250 ppm (600 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 200 ppm (470 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 750 ppm (1780 mg/m³), short term exposure limit 1000 ppm (2375 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1000 ppm (2400 mg/m³);short term exposure limit 1260 ppm(3000 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 500 ppm (1.185 mg/m³); short term exposure limit 1 ppm (2.375 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 125 ppm (295 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 500 ppm (1187 mg/m³); short term exposure limit 750 ppm (1781 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 600 mg/m³, MAC(short term exposure limit) 1800 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 200 mg/m³, short term exposure limit 800 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 250 ppm (600 mg/m³);short term exposure limit 500 ppm (1200 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 500 ppm (1200 mg/m³), KZG-week 1000 ppm (2400 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1780 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1000 ppm (2400 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 1000 ppm (2400 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 500 ppm (1210 mg/m³);short term exposure limit 1500 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1000 ppm (2400 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1000 ppm (2400 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1000 ppm (2400 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1000 ppm (2400 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE-air	10H time-weighted average 250 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 02820; Number of Industries 358; Total Number of Facilities 97342; Number of Occupations 215; Total Number of Employees Exposed 1740164; Total Number of Female Employees Exposed 540313
National Occupational Hazard Survey 1974	Hazard Code 02820; Number of Industries 350; Total Number of Facilities 99713; Number of Occupations 188; Total Number of Employees Exposed 1287794

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100095/AS)
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-mouse embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-03, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-69

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health