Acetic acid, propyl ester

RTECS #

AJ3675000

CAS #

109-60-4
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

102.15

Molecular Formula

C₅H₁₀O₂

Synonyms

1-Acetoxypropane
1-Propyl acetate
Acetate de propyle normal (French)
Acetic acid n-propyl ester
n-Propyl acetate
n-Propyl acetate (ACGIH:OSHA)
Octan propylu (Polish)
Propyl acetate
Propylester kyseliny octove (Czech)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	85JCAE -,355,1986
skin /rabbit	500 mg open irritation test	mild	UCDS** 1/25/1965

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 38 gm/m³/5H	Behavioral: General anesthetic Gastrointestinal: Changes in structure or function of salivary glands Blood: Other changes	AGGHAR 5,1,1933
inhalation/human	lowest published toxic concentration: 1000 mg/m³	Eye: Lacrimation Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes	AGGHAR 5,1,1933
inhalation/rat	Lowest published lethal concentration: 8000 ppm/4H		AIHAAP 30,470,1969
intraperitoneal/mouse	lethal dose (50 percent kill): 1420 mg/kg		SCCUR* -,8,1961
oral/mouse	lethal dose (50 percent kill): 8300 mg/kg	Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair	FCTXAV 2,327,1964
oral/rabbit	lethal dose (50 percent kill): 6640 mg/kg		IMSUAI 41,31,1972
oral/rat	lethal dose (50 percent kill): 9370 mg/kg	Behavioral: Somnolence (general depressed activity) Skin and Appendages: Other: Hair	FCTXAV 2,327,1964
skin/rabbit	lethal dose (50 percent kill): >20 mL/kg		UCDS** 1/25/1965
subcutaneous/cat	lowest published lethal dose: 3 gm/kg	Behavioral: Somnolence (general depressed activity)	AGGHAR 5,1,1933
subcutaneous/guinea pig	lowest published lethal dose: 3 gm/kg	Behavioral: Somnolence (general depressed activity)	AGGHAR 5,1,1933

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 200 ppm;short term exposure limit 250 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AMIHAB 21,28,1960

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 200 ppm (840 mg/m³)	DTLVS* 3,216,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 200 ppm (835 mg/m³), short term exposure limit 250 ppm (1040 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 200 ppm (847 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 250 ppm (1055 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 150 ppm (625 mg/m³), MAY2011
Occupational Exposure Limit-FRANCE	VME 200 ppm (840 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 100 ppm (420 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 840 mg/m³, short term exposure limit 840 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 150 ppm (625 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 200 ppm (830 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 200 ppm (840 mg/m³), short term exposure limit 250 ppm (1050 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 200 ppm (840 mg/m³);short term exposure limit 250 ppm (1050 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 200 ppm (835 mg/m³), short term exposure limit 250 ppm (1040 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 100 ppm (420 mg/m³), JAN1999
Occupational Exposure Limit-NORWAY	time-weighted average 0.001 mg(Rh)/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 200 ppm (835 mg/m³); short term exposure limit 250 ppm (1044 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 200 mg/m³, MAC(short term exposure limit) 1000 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 200 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 100 ppm (400 mg/m³);short term exposure limit 200 ppm (800 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 100 ppm (420 mg/m³), KZG-week 200 ppm (840 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 420 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 mg(Rh)/m³, JAN1993
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 200 ppm (840 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 200 ppm (840 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 200 ppm (849 mg/m³);short term exposure limit 250 ppm (1060 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 200 ppm (840 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 200 ppm (840 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 200 ppm (840 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 200 ppm (840 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-PROPYL ACETATE-air	10H time-weighted average 200 ppm;short term exposure limit 250 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 63265; Number of Industries 34; Total Number of Facilities 3859; Number of Occupations 42; Total Number of Employees Exposed 46856; Total Number of Female Employees Exposed 11660
National Occupational Hazard Survey 1974	Hazard Code 63265; Number of Industries 38; Total Number of Facilities 1960; Number of Occupations 48; Total Number of Employees Exposed 32970

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health