Acetic acid, ethyl ester

RTECS #

AH5425000

CAS #

141-78-6
See: NMAM or OSHA Methods

Updated

December 2017

Molecular Weight

88.12

Molecular Formula

C₄H₈O₂

Synonyms

Acetic ether
Acetidin
Acetoxyethane
Aethylacetat (German)
Essigester (German)
Ethyl acetate
Ethyl acetate (ACGIH:OSHA)
Ethyl acetic ester
Ethyl ethanoate
Ethylacetaat (Dutch)
Ethyle (acetate d') (French)
Ethylester kyseliny octove (Czech)
Etile (acetato di) (Italian)
Octan etylu (Polish)
RCRA waste number U112
Vinegar naphtha

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	400 ppm		JIHTAB 25,282,1943

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	fibroblast/hamster	9 gm/L	FCTOD7 22,623,1984
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	24400 ppm	MUREAV 149,339,1985

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 359 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Rabbit, ocular	Inhibitor Concentration Low: 5 pph/5M	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1855,2013
inhalation/cat	Lowest published lethal concentration: 61 gm/m³		HBTXAC 1,336,1955
inhalation/human	lowest published toxic concentration: 400 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Other changes	JIHTAB 25,282,1943
inhalation/mouse	lethal concentration (50 percent kill): 45 gm/m³/2H		85GMAT -,65,1982
inhalation/mouse	lowest published toxic concentration: 200 ppm/6M	Lung, Thorax, or Respiration: Respiratory depression	TOLED5 9,137,1981
inhalation/rat	lethal concentration (50 percent kill): 200 gm/m³	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema Gastrointestinal: Changes in structure or function of salivary glands	SRTCAC 36(1-4),10,1989
inhalation/rat	lethal concentration (50 percent kill): 1600 ppm/8H		ENTOX* -,277,2005
inhalation/rat	lethal concentration (50 percent kill): >6000 ppm/6H		ENTOX* -,277,2005
intraperitoneal/mouse	lethal dose (50 percent kill): 709 mg/kg		SCCUR* -,5,1961
oral/guinea pig	lethal dose (50 percent kill): 5.5 gm/kg		ENTOX* -,277,2005
oral/guinea pig	lethal dose (50 percent kill): 5500 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Coma	GISAAA 48(4),66,1983
oral/mouse	lethal dose (50 percent kill): 4100 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Coma	GISAAA 48(4),66,1983
oral/mouse	lethal dose (50 percent kill): 4.1 gm/kg		ENTOX* -,277,2005
oral/rabbit	lethal dose (50 percent kill): 4935 mg/kg		IMSUAI 41,31,1972
oral/rat	lethal dose (50 percent kill): 5620 mg/kg		YKYUA6 32,1241,1981
skin/rabbit	lethal dose (50 percent kill): >20 mL/kg		UCDS** 10/4/1968
subcutaneous/cat	lethal dose (50 percent kill): 3 gm/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Nausea or vomiting Blood: Other changes	AGGHAR 5,1,1933
subcutaneous/guinea pig	lethal dose (50 percent kill): 3 gm/kg	Behavioral: Somnolence (general depressed activity)	AGGHAR 5,1,1933
subcutaneous/rat	lowest published lethal dose: 5 gm/kg		BSIBAC 18,45,1943

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lowest published toxic concentration: 22 gm/m³/40M/4W- intermittent	Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Body temperature decrease	NTIS** OTS0572401
inhalation/rat	lowest published toxic concentration: 1500 ppm/90D- intermittent	Olfaction: Change in sensation of smell Olfaction: Other olfaction effects	TOPADD 27,618,1999
intraperitoneal/rat	lowest published toxic dose: 8 mL/kg/8D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Metabolism (intermediary): Other carbohydrates	BECTA6 12,612,1974

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 400 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AMIHAB 21,28,1960
TOXICOLOGY REVIEW		MUREAV 566,209,2004
TOXICOLOGY REVIEW		CHHSA* 9,6,2002
TOXICOLOGY REVIEW		ENTOX* -,277,2005
TOXICOLOGY REVIEW		HUTOX* -,577,1996
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		NETEEC 52,68,2015

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,292,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 400 ppm (1400 mg/m³)	DTLVS* 3,102,1971
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 200 ppm (720 mg/m³), short term exposure limit 400 ppm (1440 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 300 ppm (1050 mg/m³);KZW 600 ppm (2100 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 400 ppm (1461 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 150 ppm (540 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 300 ppm (1100 mg/m³), short term exposure limit 500 ppm (1800 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 400 ppm (1400 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 400 ppm (1.5 gm/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 1400 mg/m³, short term exposure limit 1400 mg/m³, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 150 ppm (540 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 200 ppm (720 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 400 ppm (1400 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 400 ppm (1400 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 200 ppm (720 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 150 ppm (550 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 400 ppm (1441 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 200 ppm, MAC(short term exposure limit) 600 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 50 mg/m³, short term exposure limit 200 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 150 ppm (500 mg/m³);short term exposure limit 300 ppm (1100 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 400 ppm (1400 mg/m³), KZG-week 800 ppm (2800 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 550 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 400 ppm (1400 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 400 ppm (1400 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 200 ppm;short term exposure limit 400 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 400 ppm (1400 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 400 ppm (1400 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 400 ppm (1400 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 400 ppm (1400 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACETATE-air	10H time-weighted average 400 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 31470; Number of Industries 234; Total Number of Facilities 40728; Number of Occupations 154; Total Number of Employees Exposed 504448; Total Number of Female Employees Exposed 119505
National Occupational Hazard Survey 1974	Hazard Code 31470; Number of Industries 234; Total Number of Facilities 37072; Number of Occupations 152; Total Number of Employees Exposed 407816

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl acetate, 1457
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health