Uracil, 5-bromo-3-sec-butyl-6-methyl-

RTECS #

YQ9100000

CAS #

314-40-9; 154670-12-9
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

261.15

Molecular Formula

C₉H₁₃BrN₂O₂

Synonyms

(+-)-Bromacil
3-sek.Butyl-5-brom-6-methyluracil (German)
5-Bromo-3-sec-butyl-6-methyluracil
5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
5-Bromo-6-methyl-3-(1-methylpropyl)uracil
Borea
Bromacil
Bromacil (ACGIH)
Bromax
Bromazil
Cynogan
Du Pont herbicide 976
Eerex Granular Weed Killer
Eerex Water Soluble Concentrate Weed Killer
Herbicide 976
Hyvar X
Hyvar X bromacil
Hyvar X Weed Killer
Hyvar X-L
Hyvar X-WS
Hyvarex
Krovar II
Nalkil
Urox B
Urox B water soluble concentrate weed killer
Urox HX granular weed killer
Urox-HX

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in mammalian somatic cells	lymphocyte/mouse	750 mg/L	NTIS** PB84-138973
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	2000 ppm	JPFCD2 15,867,1980
sex chromosome loss and nondisjunction	/Neurospora crassa	10 mg/L	MUREAV 167,35,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	38 mg/m³/2H (7-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	NTIS** PB277-077

Acute Toxicity Data and References

Route/Organism	Dose	Reference
inhalation/rat	lethal concentration (50 percent kill): >4800 mg/m³	PEMNDP 9,93,1991
oral/Dog	Lethal dose: >5 gm/kg	TXAPA9 34,189,1975
oral/mouse	lethal dose (50 percent kill): 3040 mg/kg	JPFCD2 15,867,1980
oral/rat	lethal dose (50 percent kill): 641 mg/kg	FAATDF 7,299,1986
skin/rabbit	lethal dose (50 percent kill): >5 gm/kg	PEMNDP 9,93,1991
skin/rat	lethal dose (50 percent kill): >2500 mg/kg	FAATDF 7,299,1986

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 10350 mg/kg/2W- intermittent	Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 34,189,1975
oral/rat	lowest published toxic dose: 45625 mg/kg/2Y- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 34,189,1975

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		HTOPA* 1,501,2002

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,92,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (11 mg/m³), JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (11 mg/m³), short term exposure limit 3 ppm (33 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (10 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (10 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (10 mg/m³);short term exposure limit 2 ppm (20 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (11 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (10 mg/m³), inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (11 mg/m³);short term exposure limit 2 ppm (22 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMACIL-air	10H time-weighted average 1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 80830; Number of Industries 7; Total Number of Facilities 755; Number of Occupations 6; Total Number of Employees Exposed 4372; Total Number of Female Employees Exposed 63
National Occupational Hazard Survey 1974	Hazard Code 80830; Number of Industries 11; Total Number of Facilities 362; Number of Occupations 5; Total Number of Employees Exposed 1905

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health