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Tungsten

RTECS #
YO7175000
CAS #
7440-33-7
See: NMAM or OSHA Methods
Updated
September 2018
Molecular Weight
183.85
Molecular Formula
W
Synonyms
Wolfram

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,19,1972
skin /rabbit 500 mg/24H mild28ZPAK -,19,1972

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1210 µg/kg (35W prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
GISAAA 42(8),30,1977
oral/rat 1160 µg/kg (30W prior to copulation/1-20D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFATOAO 41,620,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, kidney Inhibitor Concentration Low: 200 mg/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TXAPA9 253,178,2011
In Vitro/Human, kidney Inhibitor Concentration Low: 1000 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTXAPA9 253,178,2011
In Vitro/jahInhibitor Concentration Low: 100 mg/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TXAPA9 253,178,2011
In Vitro/maxInhibitor Concentration Low: 100 mg/L/1WIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TXAPA9 253,178,2011
In Vitro/Mouse, leukemia cells Inhibitor Concentration Low: 100 mg/L/4HIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TXAPA9 259,74,2012
intraperitoneal/rat lethal dose (50 percent kill): 5 gm/kgVascular: Regional or general arteriolar or venous dilation

Liver: Other changes

Blood: Other changes
INMEAF 15,482,1946
intratracheal/rat lowest published toxic dose: 200 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)HBTME* -,871,2007

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg(week)/m3;short term exposure limit 10 mg(week)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3;short term exposure limit 10 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,392,2005
TOXICOLOGY REVIEWHBTME* ,871,2007
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWTOLED5 265,106,2017

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-time-weighted average 5 mg/m3 (insoluble)DTLVS* 3,272,1971
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg/m3 (soluble)DTLVS* 3,272,1971
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 mg/m3;KZW 10 mg/m3, inhal, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg(W)/m3 (dust), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, dust, NOV2011
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg(W)/m3;short term exposure limit 10 mg(W)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg(W)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) fume and dust 5 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 6 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TUNGSTEN, insoluble-airtime-weighted average 5 mg(W)/m3;short term exposure limit 10 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TUNGSTEN, soluble-air10H time-weighted average 1 mg(W)/m3;short term exposure limit 3 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X5928; Number of Industries 4; Total Number of Facilities 53; Number of Occupations 11; Total Number of Employees Exposed 3907; Total Number of Female Employees Exposed 1258
National Occupational Exposure Survey 1983Hazard Code X7685; Number of Industries 5; Total Number of Facilities 174; Number of Occupations 15; Total Number of Employees Exposed 4822; Total Number of Female Employees Exposed 3021
National Occupational Exposure Survey 1983Hazard Code 74980; Number of Industries 52; Total Number of Facilities 1623; Number of Occupations 43; Total Number of Employees Exposed 38323; Total Number of Female Employees Exposed 3591
National Occupational Hazard Survey 1974Hazard Code 74980; Number of Industries 20; Total Number of Facilities 530; Number of Occupations 24; Total Number of Employees Exposed 4735

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tungsten (soluble and insoluble), 7074
OSHA ANALYTICAL METHOD #ID213
Page last reviewed: November 16, 2018