p-Toluidine
RTECS #
XU3150000
CAS #
Updated
September 2013
Molecular Weight
107.17
Molecular Formula
C7H9N
Synonyms
1-Amino-4-methylbenzene
4-Amino-1-methylbenzene
4-Aminotoluen (Czech)
4-Aminotoluene
4-Methylaniline
4-Methylbenzenamine
4-Toluidine
Aniline, p-methyl-
Benzenamine, 4-methyl- (9CI)
C.I. 37107
C.I. Azoic Coupling Component 107
Naphtol AS-KG
Naphtol AS-KGLL
p-Aminotoluene
p-Methylaniline
p-Methylbenzenamine
p-Toluidin (Czech)
p-Toluidine (ACGIH)
p-Toluidyna (Polish)
p-Tolylamine
RCRA waste number U353
Tolylamine
4-Amino-1-methylbenzene
4-Aminotoluen (Czech)
4-Aminotoluene
4-Methylaniline
4-Methylbenzenamine
4-Toluidine
Aniline, p-methyl-
Benzenamine, 4-methyl- (9CI)
C.I. 37107
C.I. Azoic Coupling Component 107
Naphtol AS-KG
Naphtol AS-KGLL
p-Aminotoluene
p-Methylaniline
p-Methylbenzenamine
p-Toluidin (Czech)
p-Toluidine (ACGIH)
p-Toluidyna (Polish)
p-Tolylamine
RCRA waste number U353
Tolylamine
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 20 mg/24H | moderate | 85JCAE -,460,1986 |
| eye /rabbit | 0.1 gm | moderate | HPV300 -,-,2001 |
| skin /rabbit | 500 mg/24H | mild | 85JCAE -,460,1986 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | intraperitoneal/mouse | 35 mg/kg | ATSUDG 5,355,1982 |
| DNA inhibition | oral/mouse | 200 mg/kg | HPV300 -,-,2001 |
| Unscheduled DNA Synthesis | liver/rat | 100 µmol/L | ENMUDM 5,803,1983 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 64800 mg/kg/72W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors Tumorigenic: Increased incidence of tumors in susceptible strains | HPV300 -,-,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 640 mg/m3/1H | HPV300 -,-,2001 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 50 mg/kg | HPV300 -,-,2001 | |
| oral/mouse | lethal dose (50 percent kill): 330 mg/kg | ENTOX* -,206,2005 | |
| oral/quail | lethal dose (50 percent kill): 237 mg/kg | AECTCV 12,355,1983 | |
| oral/rabbit | lethal dose (50 percent kill): 270 mg/kg | HPV300 -,-,2001 | |
| oral/rat | lethal dose (50 percent kill): 336 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | BCTKAG 17,51,1984 |
| oral/rat | lethal dose (50 percent kill): 620 mg/kg | HPV300 -,-,2001 | |
| oral/wild bird | lethal dose (50 percent kill): 42 mg/kg | TXAPA9 21,315,1972 | |
| skin/rabbit | lethal dose (50 percent kill): 890 mg/kg | HPV300 -,-,2001 | |
| subcutaneous/rat | lethal dose (50 percent kill): 1012 mg/kg | HPV300 -,-,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | lowest published toxic dose: 225 mg/kg/3D- continuous | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HPV300 -,,2001 |
| oral/mouse | lowest published toxic dose: 3075 mg/kg/3D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV300 -,,2001 |
| oral/rat | lowest published toxic dose: 4560 mg/kg/30D- intermittent | Kidney, Ureter, and Bladder: Proteinuria Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VINIT* #4035-77 |
| oral/rat | lowest published toxic dose: 1722 mg/kg/6W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | IJTOFN 24,365,2005 |
| oral/rat | lowest published toxic dose: 2086 mg/kg/2W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | IJTOFN 24,365,2005 |
| oral/rat | lowest published toxic dose: 1230 mg/kg/30D- continuous | Liver: Other changes Blood: Methemoglobinemia- Carboxhemoglobinemia | IJTOFN 24,365,2005 |
| oral/rat | lowest published toxic dose: 1870 mg/kg/4W- continuous | Liver: Changes in liver weight | HPV300 -,,2001 |
| oral/rat | lowest published toxic dose: 3519 mg/kg/4W- continuous | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV300 -,,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | ENTOX* -,206,2005 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-TOLUIDINE-air | Carcinogen lowest feasible conc. (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code M0854; Number of Industries 4; Total Number of Facilities 206; Number of Occupations 2; Total Number of Employees Exposed 428; Total Number of Female Employees Exposed 87 | |
| National Occupational Hazard Survey 1974 | Hazard Code M0854; Number of Industries 8; Total Number of Facilities 508; Number of Occupations 5; Total Number of Employees Exposed 2267 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health