Toluene, p-tert-butyl-
RTECS #
XS8400000
CAS #
Updated
September 2013
Molecular Weight
148.27
Molecular Formula
C11H16
Synonyms
1-Methyl-4-tert-butylbenzene
4-tert-Butyltoluene
Benzene, 1-methyl-4-(1,1-dimethylethyl)- (9CI)
p-Methyl-tert-butylbenzene
p-tert-Butyltoluene
p-tert-Butyltoluene (ACGIH:OSHA)
TBT
4-tert-Butyltoluene
Benzene, 1-methyl-4-(1,1-dimethylethyl)- (9CI)
p-Methyl-tert-butylbenzene
p-tert-Butyltoluene
p-tert-Butyltoluene (ACGIH:OSHA)
TBT
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
eye /human | 5 ppm/2H | AMIHBC 9,227,1954 | |
eye /rabbit | 100 mg | AMIHBC 9,227,1954 | |
skin /rabbit | 500 mg/24H | mild | AMIHBC 9,227,1954 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/human | lowest published toxic concentration: 10 ppm/3M | Gastrointestinal: Nausea or vomiting | AMIHBC 9,227,1954 |
inhalation/human | lowest published toxic concentration: 20 ppm/5M | Eye: Conjunctiva irritation Taste: Change in function Gastrointestinal: Nausea or vomiting | 28ZRAQ -,156,1960 |
inhalation/mouse | lethal concentration (50 percent kill): 248 ppm/4H | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Excitement | AMIHBC 9,227,1954 |
inhalation/rat | lethal concentration (50 percent kill): 165 ppm/8H | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | AMIHBC 9,227,1954 |
intraperitoneal/rat | lethal dose (50 percent kill): 275 mg/kg | VCVGH* -,184,1990 | |
intraperitoneal/rat | lethal dose (16 percent kill): 188 mg/kg | VCVGH* -,184,1990 | |
intraperitoneal/rat | lethal dose (84 percent kill): 545 mg/kg | VCVGH* -,184,1990 | |
oral/mouse | lethal dose (50 percent kill): 778 mg/kg | Behavioral: Muscle weakness Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | AMIHBC 9,227,1954 |
oral/rabbit | lethal dose (50 percent kill): 1728 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness | AMIHBC 9,227,1954 |
oral/rat | lethal dose (50 percent kill): 1555 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Dyspnea | AMIHBC 9,227,1954 |
oral/rat | lethal dose (50 percent kill): 1600 mg/kg | VCVGH* -,184,1990 | |
skin/rabbit | lethal dose (50 percent kill): 16934 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Body temperature decrease | AMIHBC 9,227,1954 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/rat | lowest published toxic concentration: 20 ppm/6H/14D- intermittent | Brain and Coverings: Recordings from specific areas of CNS | PHTOEH 76,36,1995 |
inhalation/rat | lowest published toxic concentration: 850 ppm/1H/5D- intermittent | Autonomic Nervous System: Other (direct) parasympathomimetic Lung, Thorax, or Respiration: Acute pulmonary edema Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | AMIHBC 9,227,1954 |
inhalation/rat | lowest published toxic concentration: 50 ppm/2H/26W- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in leukocyte (WBC) count | AMIHBC 9,227,1954 |
inhalation/rat | lowest published toxic concentration: 25 ppm/2H/73D- intermittent | Liver: Changes in liver weight | AMIHBC 9,227,1954 |
inhalation/rat | lowest published toxic concentration: 50 ppm/7H/37D- intermittent | Liver: Changes in liver weight | AMIHBC 9,227,1954 |
inhalation/rat | lowest published toxic concentration: 20 ppm/4W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Other proteins | PHTOEH 87,11,2000 |
inhalation/rat | lowest published toxic concentration: 40 ppm/4W- intermittent | Brain and Coverings: Recordings from specific areas of CNS Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | PHTOEH 87,11,2000 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm | DTLVS* TLV/BEI,2013 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 ppm (60 mg/m3) | DTLVS* 3,34,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 ppm (61 mg/m3), short term exposure limit 20 ppm (121 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 10 ppm (60 mg/m3);KZW 10 ppm (60 mg/m3), 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 1 ppm (6.2 mg/m3), MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (6.1 mg/m3), MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (6.1 mg/m3), ceiling concentration 5 ppm (31 mg/m3), NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 10 ppm (60 mg/m3), FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 1 ppm (6.1 mg/m3), NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 10 ppm (60 mg/m3), short term exposure limit 20 ppm (120 mg/m3), 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 10 ppm (60 mg/m3);short term exposure limit 20 ppm (120 mg/m3), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 ppm (61 mg/m3); short term exposure limit 20 ppm (121 mg/m3), JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 10 ppm (60 mg/m3), JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 1 ppm (6.1 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWITZERLAND | ceiling concentration 10 ppm (60 mg/m3), JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 6.1 mg/m3, 2003 | |
Occupational Exposure Limit-TURKEY | time-weighted average 10 ppm (60 mg/m3), JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 10 ppm (60 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-tert-BUTYLTOLUENE-air | 10H time-weighted average 10 ppm;short term exposure limit 20 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 | Hazard Code 14930; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 2; Total Number of Employees Exposed 187 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health