Sucrose

RTECS #

WN6500000

CAS #

57-50-1
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

342.34

Molecular Formula

C₁₂H₂₂O₁₁

Synonyms

(alpha-D-Glucosido)-beta-D-fructofuranoside
alpha-D-Glucopyranosyl beta-D-fructofuranoside
Beet sugar
beta-D-Fructofuranoside, alpha-D-glucopyranosyl
CANE sugar
Confectioner's sugar
Fructofuranoside, alpha-D-glucopyranosyl, beta-D
Glucopyranoside, beta-D-fructofuranosyl, alpha-D
Granulated sugar
NCI-C56597
Rock candy
Saccharose
Saccharum
Sucrose (ACGIH:OSHA)
Sugar

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lung/hamster	10 gm/L	ATSUDG 4,41,1980
Cytogenetic Analysis	ovary/hamster	275 mmol/L	MUREAV 189,15,1987
DNA repair	/Saccharomyes cerevisiae	300 mg/L	PMRSDJ 1,502,1981
mutation in microorganisms	/Salmonella typhimurium	600 µg/plate (-enzymatic activation step)	PMRSDJ 1,343,1981

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	1548 gm/kg (21D prior to copulation/1-22D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	IJMDAI 16,789,1980
oral/rat	683 gm/kg (1-21D pregnant)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	AJCNAC 28,1416,1975
oral/rat	683 gm/kg (21D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	AJCNAC 28,1416,1975
oral/mammal (species unspecified)	54810 mg/kg (15-35D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 30,203,1984

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 200 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
In Vitro/Human, lung tumor	Inhibitor Concentration (50 percent kill): >100 mg/L/48H	In Vitro Toxicity Studies: Cell protein synthesis	JOETD7 155,1393,2014
In Vitro/Rat, glioma	Inhibitor Concentration (50 percent kill): >100 mg/L/48H	In Vitro Toxicity Studies: Cell protein synthesis	JOETD7 155,1393,2014
intraperitoneal/mouse	lethal dose (50 percent kill): 14000 mg/kg		PCJOAU 15,139,1981
oral/domestic animal	lowest published lethal dose: 40 gm/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory stimulation Gastrointestinal: Hypermotility, diarrhea	NAREA4 30,503,1960
oral/human	lowest published toxic dose: 0.096 µg/kg	Behavioral: Analgesia	APHRER 39,1029,2005
oral/mouse	lowest published toxic dose: 2 mg/kg	Endocrine: Hyperglycemia	JPHSC* 104,29,2007
oral/rat	lethal dose (50 percent kill): 29700 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Hypermotility, diarrhea	TXAPA9 7,609,1965

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 2730 gm/kg/2W- continuous	Cardiac: Other changes Nutritional and Gross Metabolic: Changes in: Other metals Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	LIFSAK 71,1303,2002
oral/rat	lowest published toxic dose: 700000 mg/kg/35D- continuous	Gastrointestinal: Other changes	FCTOD7 46,752,2008
oral/rat	lowest published toxic dose: 1050 gm/kg/10W- intermittent	Endocrine: Hyperglycemia Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	JPHSC* 102,213,2006

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		HTOPA* 1,595,2002
TOXICOLOGY REVIEW		MUREAV 590,1,2005
TOXICOLOGY REVIEW		NBREV* 5,1,1981
TOXICOLOGY REVIEW		NBREV* 17,313,1993
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		RTOPDW 55,200,2009
TOXICOLOGY REVIEW		RTOPDW 60,93,2011

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD	NUISANCE PARTICULATES	DTLWS* 3,28,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³ (inspirable dust), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³, respirable dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 mg/m³, respirable dust	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³, respirable dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³, respirable dust	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCROSE, respirable fraction-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SUCROSE, total dust-air	10H time-weighted average 10 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 81515; Number of Industries 108; Total Number of Facilities 15179; Number of Occupations 110; Total Number of Employees Exposed 368912; Total Number of Female Employees Exposed 169962
National Occupational Hazard Survey 1974	Hazard Code 81515; Number of Industries 101; Total Number of Facilities 12044; Number of Occupations 86; Total Number of Employees Exposed 121005

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health